GPANK1 (G-patch domain and ankyrin repeats 1)

Gene

• Entrez ID: 7918
• Gene name: G-patch domain and ankyrin repeats 1
• Gene symbol: GPANK1
• Synonyms (NCBI Gene): ANKRD59, BAT4, D6S54E, G5, GPATCH10
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024275	hsa-miR-215-5p	Microarray	19074876
MIRT1028157	hsa-miR-2861	CLIP-seq
MIRT1028158	hsa-miR-3161	CLIP-seq
MIRT1028159	hsa-miR-3187-3p	CLIP-seq
MIRT1028160	hsa-miR-3667-3p	CLIP-seq
MIRT1028161	hsa-miR-3677-3p	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028163	hsa-miR-4297	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028165	hsa-miR-4435	CLIP-seq
MIRT1028166	hsa-miR-4453	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028168	hsa-miR-4522	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028170	hsa-miR-4538	CLIP-seq
MIRT1028171	hsa-miR-4690-3p	CLIP-seq
MIRT1028172	hsa-miR-4701-5p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT1028175	hsa-miR-588	CLIP-seq
MIRT1028176	hsa-miR-1182	CLIP-seq
MIRT1028177	hsa-miR-15a	CLIP-seq
MIRT1028178	hsa-miR-15b	CLIP-seq
MIRT1028179	hsa-miR-16	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT1028182	hsa-miR-195	CLIP-seq
MIRT1028183	hsa-miR-214	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028185	hsa-miR-3136-3p	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT1028189	hsa-miR-3545-3p	CLIP-seq
MIRT1028190	hsa-miR-3619-5p	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028194	hsa-miR-424	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028196	hsa-miR-4257	CLIP-seq
MIRT1028197	hsa-miR-4271	CLIP-seq
MIRT1028198	hsa-miR-4291	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT1028202	hsa-miR-4494	CLIP-seq
MIRT1028203	hsa-miR-4537	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028207	hsa-miR-4710	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028209	hsa-miR-4725-3p	CLIP-seq
MIRT1028210	hsa-miR-4726-3p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028212	hsa-miR-4771	CLIP-seq
MIRT1028213	hsa-miR-4780	CLIP-seq
MIRT1028214	hsa-miR-4792	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028217	hsa-miR-497	CLIP-seq
MIRT1028218	hsa-miR-499a-5p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT1028220	hsa-miR-623	CLIP-seq
MIRT1028221	hsa-miR-761	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028223	hsa-miR-922	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2005000	hsa-miR-4307	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT2237693	hsa-miR-1285	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT2237695	hsa-miR-3187-5p	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT2237696	hsa-miR-4476	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT1028203	hsa-miR-4537	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028207	hsa-miR-4710	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028214	hsa-miR-4792	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028218	hsa-miR-499a-5p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2237698	hsa-miR-612	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT2237700	hsa-miR-661	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT2237693	hsa-miR-1285	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028181	hsa-miR-188-5p	CLIP-seq
MIRT2541703	hsa-miR-217	CLIP-seq
MIRT1028184	hsa-miR-25	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT2237695	hsa-miR-3187-5p	CLIP-seq
MIRT1028188	hsa-miR-32	CLIP-seq
MIRT2541704	hsa-miR-3613-3p	CLIP-seq
MIRT1028191	hsa-miR-363	CLIP-seq
MIRT1028192	hsa-miR-367	CLIP-seq
MIRT2541705	hsa-miR-371-5p	CLIP-seq
MIRT2541706	hsa-miR-371b-5p	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028199	hsa-miR-4325	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT2541707	hsa-miR-4738-3p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028213	hsa-miR-4780	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT1028219	hsa-miR-508-5p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT2237698	hsa-miR-612	CLIP-seq
MIRT1028220	hsa-miR-623	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT2237700	hsa-miR-661	CLIP-seq
MIRT1028222	hsa-miR-766	CLIP-seq
MIRT1028224	hsa-miR-92a	CLIP-seq
MIRT1028225	hsa-miR-92b	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq
MIRT2237691	hsa-miR-1268	CLIP-seq
MIRT2237692	hsa-miR-1268b	CLIP-seq
MIRT1028180	hsa-miR-1827	CLIP-seq
MIRT1028186	hsa-miR-3150a-3p	CLIP-seq
MIRT2237694	hsa-miR-3151	CLIP-seq
MIRT1028187	hsa-miR-3175	CLIP-seq
MIRT1028162	hsa-miR-3926	CLIP-seq
MIRT1028193	hsa-miR-3929	CLIP-seq
MIRT1028195	hsa-miR-4253	CLIP-seq
MIRT1028200	hsa-miR-4419b	CLIP-seq
MIRT1028164	hsa-miR-4434	CLIP-seq
MIRT1028201	hsa-miR-4478	CLIP-seq
MIRT2450527	hsa-miR-4486	CLIP-seq
MIRT1028167	hsa-miR-4516	CLIP-seq
MIRT1028169	hsa-miR-4531	CLIP-seq
MIRT1028204	hsa-miR-4649-3p	CLIP-seq
MIRT1028205	hsa-miR-4667-5p	CLIP-seq
MIRT2450528	hsa-miR-4684-5p	CLIP-seq
MIRT1028206	hsa-miR-4700-5p	CLIP-seq
MIRT1028208	hsa-miR-4722-5p	CLIP-seq
MIRT1028211	hsa-miR-4768-3p	CLIP-seq
MIRT1028173	hsa-miR-4802-3p	CLIP-seq
MIRT1028215	hsa-miR-485-5p	CLIP-seq
MIRT1028216	hsa-miR-486-3p	CLIP-seq
MIRT2237697	hsa-miR-541	CLIP-seq
MIRT2450529	hsa-miR-548c-3p	CLIP-seq
MIRT1028174	hsa-miR-548s	CLIP-seq
MIRT2450530	hsa-miR-585	CLIP-seq
MIRT2237699	hsa-miR-654-5p	CLIP-seq
MIRT1028226	hsa-miR-939	CLIP-seq
MIRT1028227	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28514442, 31515488, 32296183, 32814053

Other IDs

• MIM: 142610
• HGNC: 13920
• e!Ensembl: ENSG00000204438

Protein

• UniProt ID: O95872
• Protein name: G patch domain and ankyrin repeat-containing protein 1 (Ankyrin repeat domain-containing protein 59) (G patch domain-containing protein 10) (HLA-B-associated transcript 4) (Protein G5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13637	Ank_4	104 → 163		Repeat
  PF01585	G-patch	255 → 299	G-patch domain	Family

• Sequence:

  MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRS
  QTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPEL
  RRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDA
  AQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSL
  SQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRS
  APQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF

• Sequence length: 356

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	17632545
Myasthenia gravis	Myasthenia Gravis	rs5030818, rs121912815, rs121912817, rs121912818, rs121912821, rs75466054, rs121912822, rs121912823, rs794727516, rs764497513, rs376808313, rs1279554995, rs1554802792, rs369251527, rs372760913, rs1554802808, rs769234940, rs201439531, rs1272947184, rs757303526, rs760936252, rs1590576560, rs1838635262	23055271
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	21156761, 17804836, 19503088

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma			GWAS
Takayasu Arteritis	Takayasu Arteritis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Celiac Disease	Associate	28282431
Lymphoma Large B Cell Diffuse	Associate	21148756
Lymphoma Non Hodgkin	Associate	21148756, 28282431
Sarcoma Kaposi	Associate	25008864