CENPO (centromere protein O)

Gene

• Entrez ID: 79172
• Gene name: Centromere protein O
• Gene symbol: CENPO
• Synonyms (NCBI Gene): CENP-O, ICEN-36, MCM21R
• Chromosome: 2
• Chromosome location: 2p23.3
• Summary: This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024229	hsa-miR-218-5p	Sequencing	20371350
MIRT712567	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT712566	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT712565	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT712564	hsa-miR-4262	HITS-CLIP	19536157
MIRT712563	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT712562	hsa-miR-543	HITS-CLIP	19536157
MIRT712561	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712560	hsa-miR-4787-5p	HITS-CLIP	19536157
MIRT712559	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT712567	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT712566	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT712565	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT712564	hsa-miR-4262	HITS-CLIP	19536157
MIRT712563	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT712562	hsa-miR-543	HITS-CLIP	19536157
MIRT712561	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712560	hsa-miR-4787-5p	HITS-CLIP	19536157
MIRT712559	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT302119	hsa-miR-1825	HITS-CLIP	19536157
MIRT712557	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT712556	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT712567	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT712566	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT712565	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT712564	hsa-miR-4262	HITS-CLIP	19536157
MIRT712563	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT712562	hsa-miR-543	HITS-CLIP	19536157
MIRT712561	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712560	hsa-miR-4787-5p	HITS-CLIP	19536157
MIRT712559	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT302119	hsa-miR-1825	HITS-CLIP	19536157
MIRT712557	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT712556	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT735999	hsa-miR-519d-3p	Microarray	31545079
MIRT712567	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT712566	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT712565	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT712564	hsa-miR-4262	HITS-CLIP	19536157
MIRT712563	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT712562	hsa-miR-543	HITS-CLIP	19536157
MIRT712561	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712560	hsa-miR-4787-5p	HITS-CLIP	19536157
MIRT712559	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT302119	hsa-miR-1825	HITS-CLIP	19536157
MIRT712557	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT712556	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT712567	hsa-miR-181b-5p	HITS-CLIP	19536157
MIRT712566	hsa-miR-181c-5p	HITS-CLIP	19536157
MIRT712565	hsa-miR-181d-5p	HITS-CLIP	19536157
MIRT712564	hsa-miR-4262	HITS-CLIP	19536157
MIRT712563	hsa-miR-181a-5p	HITS-CLIP	19536157
MIRT712562	hsa-miR-543	HITS-CLIP	19536157
MIRT712561	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712560	hsa-miR-4787-5p	HITS-CLIP	19536157
MIRT712559	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT712558	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT302119	hsa-miR-1825	HITS-CLIP	19536157
MIRT712557	hsa-miR-199a-5p	HITS-CLIP	19536157
MIRT712556	hsa-miR-199b-5p	HITS-CLIP	19536157
MIRT712555	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT712554	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT712553	hsa-miR-3621	HITS-CLIP	19536157
MIRT885221	hsa-miR-1200	CLIP-seq
MIRT885222	hsa-miR-1252	CLIP-seq
MIRT885223	hsa-miR-128	CLIP-seq
MIRT885224	hsa-miR-1294	CLIP-seq
MIRT885225	hsa-miR-129-5p	CLIP-seq
MIRT885226	hsa-miR-1302	CLIP-seq
MIRT885227	hsa-miR-1321	CLIP-seq
MIRT885228	hsa-miR-1343	CLIP-seq
MIRT885229	hsa-miR-136	CLIP-seq
MIRT885230	hsa-miR-139-3p	CLIP-seq
MIRT885231	hsa-miR-141	CLIP-seq
MIRT885232	hsa-miR-185	CLIP-seq
MIRT885233	hsa-miR-200a	CLIP-seq
MIRT885234	hsa-miR-27a	CLIP-seq
MIRT885235	hsa-miR-27b	CLIP-seq
MIRT885236	hsa-miR-31	CLIP-seq
MIRT885237	hsa-miR-3184	CLIP-seq
MIRT885238	hsa-miR-3616-5p	CLIP-seq
MIRT885239	hsa-miR-3647-3p	CLIP-seq
MIRT885240	hsa-miR-3647-5p	CLIP-seq
MIRT885241	hsa-miR-3667-3p	CLIP-seq
MIRT885242	hsa-miR-3688-5p	CLIP-seq
MIRT885243	hsa-miR-3690	CLIP-seq
MIRT885244	hsa-miR-3714	CLIP-seq
MIRT885245	hsa-miR-423-5p	CLIP-seq
MIRT885246	hsa-miR-4254	CLIP-seq
MIRT885247	hsa-miR-4298	CLIP-seq
MIRT885248	hsa-miR-4306	CLIP-seq
MIRT885249	hsa-miR-4459	CLIP-seq
MIRT885250	hsa-miR-4487	CLIP-seq
MIRT885251	hsa-miR-4644	CLIP-seq
MIRT885252	hsa-miR-4716-5p	CLIP-seq
MIRT885253	hsa-miR-4738-3p	CLIP-seq
MIRT885254	hsa-miR-4739	CLIP-seq
MIRT885255	hsa-miR-4747-5p	CLIP-seq
MIRT885256	hsa-miR-4755-3p	CLIP-seq
MIRT885257	hsa-miR-4756-5p	CLIP-seq
MIRT885258	hsa-miR-4768-3p	CLIP-seq
MIRT885259	hsa-miR-4779	CLIP-seq
MIRT885260	hsa-miR-4795-5p	CLIP-seq
MIRT885261	hsa-miR-519a	CLIP-seq
MIRT885262	hsa-miR-519b-3p	CLIP-seq
MIRT885263	hsa-miR-519c-3p	CLIP-seq
MIRT885264	hsa-miR-573	CLIP-seq
MIRT885265	hsa-miR-576-3p	CLIP-seq
MIRT885266	hsa-miR-665	CLIP-seq
MIRT885267	hsa-miR-106a	CLIP-seq
MIRT885268	hsa-miR-106b	CLIP-seq
MIRT885269	hsa-miR-1299	CLIP-seq
MIRT885226	hsa-miR-1302	CLIP-seq
MIRT885270	hsa-miR-130a	CLIP-seq
MIRT885271	hsa-miR-130b	CLIP-seq
MIRT885272	hsa-miR-146a	CLIP-seq
MIRT885273	hsa-miR-146b-5p	CLIP-seq
MIRT885274	hsa-miR-148a	CLIP-seq
MIRT885275	hsa-miR-148b	CLIP-seq
MIRT885276	hsa-miR-152	CLIP-seq
MIRT885277	hsa-miR-17	CLIP-seq
MIRT885278	hsa-miR-20a	CLIP-seq
MIRT885279	hsa-miR-20b	CLIP-seq
MIRT885280	hsa-miR-301a	CLIP-seq
MIRT885281	hsa-miR-301b	CLIP-seq
MIRT885282	hsa-miR-3127-3p	CLIP-seq
MIRT885283	hsa-miR-3182	CLIP-seq
MIRT885237	hsa-miR-3184	CLIP-seq
MIRT885284	hsa-miR-3666	CLIP-seq
MIRT885285	hsa-miR-3921	CLIP-seq
MIRT885245	hsa-miR-423-5p	CLIP-seq
MIRT885286	hsa-miR-4295	CLIP-seq
MIRT885247	hsa-miR-4298	CLIP-seq
MIRT885287	hsa-miR-4421	CLIP-seq
MIRT885249	hsa-miR-4459	CLIP-seq
MIRT885288	hsa-miR-4467	CLIP-seq
MIRT885250	hsa-miR-4487	CLIP-seq
MIRT885289	hsa-miR-4502	CLIP-seq
MIRT885290	hsa-miR-454	CLIP-seq
MIRT885291	hsa-miR-4635	CLIP-seq
MIRT885292	hsa-miR-4651	CLIP-seq
MIRT885293	hsa-miR-4653-5p	CLIP-seq
MIRT885294	hsa-miR-4659a-3p	CLIP-seq
MIRT885295	hsa-miR-4659b-3p	CLIP-seq
MIRT885296	hsa-miR-4768-5p	CLIP-seq
MIRT885297	hsa-miR-4773	CLIP-seq
MIRT885259	hsa-miR-4779	CLIP-seq
MIRT885298	hsa-miR-4782-5p	CLIP-seq
MIRT885299	hsa-miR-488	CLIP-seq
MIRT885300	hsa-miR-516b	CLIP-seq
MIRT885261	hsa-miR-519a	CLIP-seq
MIRT885262	hsa-miR-519b-3p	CLIP-seq
MIRT885263	hsa-miR-519c-3p	CLIP-seq
MIRT885301	hsa-miR-519d	CLIP-seq
MIRT885302	hsa-miR-570	CLIP-seq
MIRT885303	hsa-miR-589	CLIP-seq
MIRT885304	hsa-miR-608	CLIP-seq
MIRT885305	hsa-miR-875-3p	CLIP-seq
MIRT885306	hsa-miR-93	CLIP-seq
MIRT1962564	hsa-miR-142-3p	CLIP-seq
MIRT1962565	hsa-miR-3180-5p	CLIP-seq
MIRT885237	hsa-miR-3184	CLIP-seq
MIRT885285	hsa-miR-3921	CLIP-seq
MIRT885245	hsa-miR-423-5p	CLIP-seq
MIRT885293	hsa-miR-4653-5p	CLIP-seq
MIRT1962566	hsa-miR-4728-5p	CLIP-seq
MIRT1962567	hsa-miR-520a-5p	CLIP-seq
MIRT1962568	hsa-miR-525-5p	CLIP-seq
MIRT1962569	hsa-miR-550a	CLIP-seq
MIRT1962570	hsa-miR-1224-5p	CLIP-seq
MIRT1962571	hsa-miR-1273f	CLIP-seq
MIRT1962572	hsa-miR-135a	CLIP-seq
MIRT1962573	hsa-miR-135b	CLIP-seq
MIRT885232	hsa-miR-185	CLIP-seq
MIRT1962574	hsa-miR-28-5p	CLIP-seq
MIRT1962575	hsa-miR-3139	CLIP-seq
MIRT1962576	hsa-miR-3150b-3p	CLIP-seq
MIRT1962577	hsa-miR-3152-3p	CLIP-seq
MIRT1962578	hsa-miR-3179	CLIP-seq
MIRT1962579	hsa-miR-323-3p	CLIP-seq
MIRT1962580	hsa-miR-3936	CLIP-seq
MIRT1962581	hsa-miR-4266	CLIP-seq
MIRT1962582	hsa-miR-4303	CLIP-seq
MIRT885248	hsa-miR-4306	CLIP-seq
MIRT1962583	hsa-miR-4474-3p	CLIP-seq
MIRT1962584	hsa-miR-4494	CLIP-seq
MIRT1962585	hsa-miR-4536	CLIP-seq
MIRT1962586	hsa-miR-4539	CLIP-seq
MIRT885251	hsa-miR-4644	CLIP-seq
MIRT1962587	hsa-miR-4649-3p	CLIP-seq
MIRT1962588	hsa-miR-4687-3p	CLIP-seq
MIRT1962589	hsa-miR-4751	CLIP-seq
MIRT1962590	hsa-miR-4761-5p	CLIP-seq
MIRT1962591	hsa-miR-4784	CLIP-seq
MIRT1962592	hsa-miR-499a-5p	CLIP-seq
MIRT1962593	hsa-miR-513a-5p	CLIP-seq
MIRT885300	hsa-miR-516b	CLIP-seq
MIRT1962594	hsa-miR-552	CLIP-seq
MIRT1962595	hsa-miR-624	CLIP-seq
MIRT1962596	hsa-miR-644	CLIP-seq
MIRT1962597	hsa-miR-663b	CLIP-seq
MIRT1962598	hsa-miR-708	CLIP-seq
MIRT2198899	hsa-miR-4419a	CLIP-seq
MIRT2198900	hsa-miR-4480	CLIP-seq
MIRT2198901	hsa-miR-4510	CLIP-seq
MIRT885221	hsa-miR-1200	CLIP-seq
MIRT885230	hsa-miR-139-3p	CLIP-seq
MIRT2446862	hsa-miR-4326	CLIP-seq
MIRT2446863	hsa-miR-4655-3p	CLIP-seq
MIRT2446864	hsa-miR-4694-5p	CLIP-seq
MIRT885267	hsa-miR-106a	CLIP-seq
MIRT885268	hsa-miR-106b	CLIP-seq
MIRT885221	hsa-miR-1200	CLIP-seq
MIRT885269	hsa-miR-1299	CLIP-seq
MIRT885270	hsa-miR-130a	CLIP-seq
MIRT885271	hsa-miR-130b	CLIP-seq
MIRT885230	hsa-miR-139-3p	CLIP-seq
MIRT885272	hsa-miR-146a	CLIP-seq
MIRT885273	hsa-miR-146b-5p	CLIP-seq
MIRT885277	hsa-miR-17	CLIP-seq
MIRT885278	hsa-miR-20a	CLIP-seq
MIRT885279	hsa-miR-20b	CLIP-seq
MIRT885280	hsa-miR-301a	CLIP-seq
MIRT885281	hsa-miR-301b	CLIP-seq
MIRT885282	hsa-miR-3127-3p	CLIP-seq
MIRT885283	hsa-miR-3182	CLIP-seq
MIRT2501672	hsa-miR-3622a-3p	CLIP-seq
MIRT2501673	hsa-miR-3622b-3p	CLIP-seq
MIRT885284	hsa-miR-3666	CLIP-seq
MIRT885286	hsa-miR-4295	CLIP-seq
MIRT2446862	hsa-miR-4326	CLIP-seq
MIRT885287	hsa-miR-4421	CLIP-seq
MIRT885290	hsa-miR-454	CLIP-seq
MIRT885291	hsa-miR-4635	CLIP-seq
MIRT2446863	hsa-miR-4655-3p	CLIP-seq
MIRT885294	hsa-miR-4659a-3p	CLIP-seq
MIRT885295	hsa-miR-4659b-3p	CLIP-seq
MIRT2446864	hsa-miR-4694-5p	CLIP-seq
MIRT885297	hsa-miR-4773	CLIP-seq
MIRT885298	hsa-miR-4782-5p	CLIP-seq
MIRT885299	hsa-miR-488	CLIP-seq
MIRT2501674	hsa-miR-5096	CLIP-seq
MIRT885300	hsa-miR-516b	CLIP-seq
MIRT885261	hsa-miR-519a	CLIP-seq
MIRT885262	hsa-miR-519b-3p	CLIP-seq
MIRT885263	hsa-miR-519c-3p	CLIP-seq
MIRT885301	hsa-miR-519d	CLIP-seq
MIRT885303	hsa-miR-589	CLIP-seq
MIRT885305	hsa-miR-875-3p	CLIP-seq
MIRT885306	hsa-miR-93	CLIP-seq
MIRT885267	hsa-miR-106a	CLIP-seq
MIRT885268	hsa-miR-106b	CLIP-seq
MIRT885221	hsa-miR-1200	CLIP-seq
MIRT885269	hsa-miR-1299	CLIP-seq
MIRT885270	hsa-miR-130a	CLIP-seq
MIRT885271	hsa-miR-130b	CLIP-seq
MIRT885230	hsa-miR-139-3p	CLIP-seq
MIRT885272	hsa-miR-146a	CLIP-seq
MIRT885273	hsa-miR-146b-5p	CLIP-seq
MIRT885277	hsa-miR-17	CLIP-seq
MIRT885278	hsa-miR-20a	CLIP-seq
MIRT885279	hsa-miR-20b	CLIP-seq
MIRT885280	hsa-miR-301a	CLIP-seq
MIRT885281	hsa-miR-301b	CLIP-seq
MIRT885282	hsa-miR-3127-3p	CLIP-seq
MIRT885283	hsa-miR-3182	CLIP-seq
MIRT885284	hsa-miR-3666	CLIP-seq
MIRT885286	hsa-miR-4295	CLIP-seq
MIRT2446862	hsa-miR-4326	CLIP-seq
MIRT885287	hsa-miR-4421	CLIP-seq
MIRT2678016	hsa-miR-4464	CLIP-seq
MIRT885290	hsa-miR-454	CLIP-seq
MIRT885291	hsa-miR-4635	CLIP-seq
MIRT2446863	hsa-miR-4655-3p	CLIP-seq
MIRT885294	hsa-miR-4659a-3p	CLIP-seq
MIRT885295	hsa-miR-4659b-3p	CLIP-seq
MIRT2446864	hsa-miR-4694-5p	CLIP-seq
MIRT2678017	hsa-miR-4748	CLIP-seq
MIRT885297	hsa-miR-4773	CLIP-seq
MIRT885298	hsa-miR-4782-5p	CLIP-seq
MIRT885299	hsa-miR-488	CLIP-seq
MIRT885300	hsa-miR-516b	CLIP-seq
MIRT885261	hsa-miR-519a	CLIP-seq
MIRT885262	hsa-miR-519b-3p	CLIP-seq
MIRT885263	hsa-miR-519c-3p	CLIP-seq
MIRT885301	hsa-miR-519d	CLIP-seq
MIRT885303	hsa-miR-589	CLIP-seq
MIRT885305	hsa-miR-875-3p	CLIP-seq
MIRT885306	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IEA
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0005515	Function	Protein binding	IPI	16189514, 19447967, 25416956, 26496610, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	NAS	36085283
GO:0016604	Component	Nuclear body	IDA
GO:0031511	Component	Mis6-Sim4 complex	IBA
GO:0034508	Process	Centromere complex assembly	IEA

Other IDs

• MIM: 611504
• HGNC: 28152
• e!Ensembl: ENSG00000138092

Protein

• UniProt ID: Q9BU64
• Protein name: Centromere protein O (CENP-O) (Interphase centromere complex protein 36)
• Protein function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesiz
• PDB: 7PB8, 7PKN, 7QOO, 7R5S, 7R5V, 7XHN, 7XHO, 7YWX, 7YYH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09496	CENP-O	119 → 268	Cenp-O kinetochore centromere component	Family

• Sequence:

  MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRD
  ELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSR
  GVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSL
  CEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYK
  DLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS
  

• Sequence length: 300

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation