WDR77 (WD repeat domain 77)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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79084 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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WD repeat domain 77 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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WDR77 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50 |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p13.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be inv |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q9BQA1 | ||||||||||
| Protein name | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | ||||||||||
| Protein function | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm prot | ||||||||||
| PDB | 4GQB , 4X60 , 4X61 , 4X63 , 5C9Z , 5EMJ , 5EMK , 5EML , 5EMM , 5FA5 , 6CKC , 6K1S , 6RLL , 6RLQ , 6UGH , 6UXX , 6UXY , 6V0N , 6V0O , 6V0P , 7BO7 , 7KIB , 7KIC , 7KID , 7L1G , 7M05 , 7MX7 , 7MXA , 7MXC , 7MXG , 7MXN , 7S0U , 7S1P , 7S1Q , 7S1R , 7S1S , 7SER , 7SES , 7U30 , 7UOH , 7UY1 , 7UYF , 7ZUP , 7ZUQ , 7ZUU , 7ZUY , 7ZV2 , 7ZVL , 7ZVU , 8CSG , 8CTB | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in semi | ||||||||||
| Sequence |
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| Sequence length | 342 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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