Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79072
Gene name Gene Name - the full gene name approved by the HGNC.	FAST kinase domains 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FASTKD3
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p15.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-bind

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miRTarBase ID	miRNA	Experiments
MIRT989742	hsa-miR-2276	CLIP-seq
MIRT989743	hsa-miR-23a	CLIP-seq
MIRT989744	hsa-miR-23b	CLIP-seq
MIRT989745	hsa-miR-23c	CLIP-seq
MIRT989746	hsa-miR-3120-3p	CLIP-seq
MIRT989747	hsa-miR-4452	CLIP-seq
MIRT989748	hsa-miR-4528	CLIP-seq
MIRT989749	hsa-miR-4760-3p	CLIP-seq
MIRT989750	hsa-miR-4772-3p	CLIP-seq
MIRT989751	hsa-miR-4773	CLIP-seq
MIRT989752	hsa-miR-4778-5p	CLIP-seq
MIRT989753	hsa-miR-4796-3p	CLIP-seq
MIRT989754	hsa-miR-518a-5p	CLIP-seq
MIRT989755	hsa-miR-520g	CLIP-seq
MIRT989756	hsa-miR-520h	CLIP-seq
MIRT989757	hsa-miR-527	CLIP-seq
MIRT989758	hsa-miR-544	CLIP-seq
MIRT989747	hsa-miR-4452	CLIP-seq
MIRT1548585	hsa-miR-4729	CLIP-seq
MIRT1548586	hsa-miR-664	CLIP-seq
MIRT1993329	hsa-miR-200b	CLIP-seq
MIRT1993330	hsa-miR-200c	CLIP-seq
MIRT989746	hsa-miR-3120-3p	CLIP-seq
MIRT1993331	hsa-miR-374c	CLIP-seq
MIRT1993332	hsa-miR-429	CLIP-seq
MIRT989747	hsa-miR-4452	CLIP-seq
MIRT1993333	hsa-miR-4682	CLIP-seq
MIRT1548585	hsa-miR-4729	CLIP-seq
MIRT989751	hsa-miR-4773	CLIP-seq
MIRT1993334	hsa-miR-655	CLIP-seq
MIRT1548586	hsa-miR-664	CLIP-seq
MIRT2227170	hsa-miR-1226	CLIP-seq
MIRT1993329	hsa-miR-200b	CLIP-seq
MIRT1993330	hsa-miR-200c	CLIP-seq
MIRT989742	hsa-miR-2276	CLIP-seq
MIRT989743	hsa-miR-23a	CLIP-seq
MIRT989744	hsa-miR-23b	CLIP-seq
MIRT989745	hsa-miR-23c	CLIP-seq
MIRT2227171	hsa-miR-3160-5p	CLIP-seq
MIRT1993331	hsa-miR-374c	CLIP-seq
MIRT2227172	hsa-miR-3942-3p	CLIP-seq
MIRT1993332	hsa-miR-429	CLIP-seq
MIRT989748	hsa-miR-4528	CLIP-seq
MIRT1993333	hsa-miR-4682	CLIP-seq
MIRT2227173	hsa-miR-4733-3p	CLIP-seq
MIRT989749	hsa-miR-4760-3p	CLIP-seq
MIRT989750	hsa-miR-4772-3p	CLIP-seq
MIRT989751	hsa-miR-4773	CLIP-seq
MIRT989752	hsa-miR-4778-5p	CLIP-seq
MIRT989753	hsa-miR-4796-3p	CLIP-seq
MIRT989754	hsa-miR-518a-5p	CLIP-seq
MIRT989755	hsa-miR-520g	CLIP-seq
MIRT989756	hsa-miR-520h	CLIP-seq
MIRT989757	hsa-miR-527	CLIP-seq
MIRT989758	hsa-miR-544	CLIP-seq
MIRT2227174	hsa-miR-587	CLIP-seq
MIRT1993334	hsa-miR-655	CLIP-seq
MIRT2531129	hsa-miR-3117-5p	CLIP-seq
MIRT2531130	hsa-miR-3923	CLIP-seq
MIRT2531131	hsa-miR-4282	CLIP-seq
MIRT2531132	hsa-miR-4704-5p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	IDA	20869947, 27789713
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IDA	27789713
GO:0044528	Process	Regulation of mitochondrial mRNA stability	IDA	27789713
GO:0070131	Process	Positive regulation of mitochondrial translation	IDA	27789713

MIM	HGNC	e!Ensembl
617530	28758	ENSG00000124279

Protein

UniProt ID

Q14CZ7

Protein name

FAST kinase domain-containing protein 3, mitochondrial

Protein function

Required for normal mitochondrial respiration (PubMed:20869947). Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increase

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06743	FAST_1	409 → 477	FAST kinase-like protein, subdomain 1	Family
PF08368	FAST_2	490 → 580	FAST kinase-like protein, subdomain 2	Family
PF08373	RAP	593 → 650	RAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in liver and thyroid. {ECO:0000269|PubMed:20869947}.

Sequence

MALITLRKNLYRLSDFQMHRALAALKNKPLNHVHKVVKERLCPWLCSRQPEPFGVKFHHA
HCKKFHSKNGNDLHPLGGPVFSQVSDCDRLEQNVKNEESQMFYRRLSNLTSSEEVLSFIS
TMETLPDTMAAGALQRICEVEKKDGDQGLPKEILENSIFQALCFQFEKEPSQLSNTSLVT
ALQALILLHVDPQSSLLLNLVAECQNRLRKGGMEVRNLCILGESLITLHSSGCVTLELII
NQLQGEKLETFTPEDIVALYRILQACTEKVDEHQTFLNKINNFSLSIVSNLSPKLISQML
TALVVLDQSQAFPLIIKLGKYVVRHVPHFTNEELRRVLEAFIYFGHHDTFFTKALEHRVA
AVCLTLDPEVVCRVMEYCSRELILSKPILNAVAETFVCQTEKFSPRQISALMEPFGKLNY
LPPNASALFRKLENVLFTHFNYFPPKSLLKLLHSCSLNECHPVNFLAKIFKPLFLQRLQG
KESHLDTLSRAQLTQLFLASVLECPFYKGPKLLPKYQVKSFLTPCCSLETPVDSQLYRYV
KIGLTNLLGARLYFAPKVLTPYCYTIDVEIKLDEEGFVLPSTANEDIHKRIALCIDGPKR
FCSNSKHLLGKEAIKQRHLQLLGYQVVQIPYHEIGMLKSRRELVEYLQRKLFSQNTVHWL
QE

Sequence length

662

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Neoplasms	Associate	34768773
Ovarian Neoplasms	Associate	34768773

FASTKD3 (FAST kinase domains 3)