Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79071
Gene name Gene Name - the full gene name approved by the HGNC.
ELOVL fatty acid elongase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ELOVL6
Synonyms (NCBI Gene) Gene synonyms aliases
FACE, FAE, LCE, hELO2
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q25
Summary Summary of gene provided in NCBI Entrez Gene.
Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006461 hsa-miR-204-5p Immunofluorescence, Microarray, qRT-PCR, Western blot 22523078
MIRT006463 hsa-miR-211-5p Immunofluorescence, Microarray, qRT-PCR, Western blot 22523078
MIRT006461 hsa-miR-204-5p Immunofluorescence, Microarray, qRT-PCR, Western blot 22523078
MIRT006463 hsa-miR-211-5p Immunofluorescence, Microarray, qRT-PCR, Western blot 22523078
MIRT017106 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20937905, 32296183
GO:0005783 Component Endoplasmic reticulum IDA 20937905
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0006636 Process Unsaturated fatty acid biosynthetic process IEA
GO:0009922 Function Fatty acid elongase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611546 15829 ENSG00000170522
Protein
UniProt ID Q9H5J4
Protein name Very long chain fatty acid elongase 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Elongation of very long chain fatty acids protein 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Lon
Protein function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01151 ELO 25 262 GNS1/SUR4 family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:20937905}.
Sequence
Sequence length 265
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Fatty acid elongation
Biosynthesis of unsaturated fatty acids
Metabolic pathways
Fatty acid metabolism
  Activation of gene expression by SREBF (SREBP)
Synthesis of very long-chain fatty acyl-CoAs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 26670611 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 26670611 ClinVar
Myocardial infarction Myocardial Failure 26670611 ClinVar
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37682172
Adenocarcinoma of Lung Stimulate 39794751
Azoospermia Nonobstructive Associate 24842676
Carcinoma Hepatocellular Associate 34981667
Cardiovascular Diseases Associate 32231389
Colonic Neoplasms Associate 36532007, 38186579
Colorectal Neoplasms Associate 28214830, 32144313, 38186579
Crohn Disease Associate 31956234
Dermatitis Allergic Contact Associate 21995181
Dermatitis Atopic Inhibit 35462437