Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79068
Gene name	FTO alpha-ketoglutarate dependent dioxygenase
Gene symbol	FTO
Synonyms (NCBI Gene)	ALKBH9BMIQ14GDFDIFEX9
Chromosome	16
Chromosome location	16q12.2
Summary	This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damag

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1421085	T>C	Risk-factor	Intron variant
rs121918214	G>A	Pathogenic	Genic downstream transcript variant, intron variant, coding sequence variant, missense variant, non coding transcript variant
rs781028867	C>A,T	Pathogenic	Genic downstream transcript variant, missense variant, non coding transcript variant, coding sequence variant, intron variant
rs1410999299	A>G	Likely-pathogenic	5 prime UTR variant, intron variant, missense variant, non coding transcript variant, coding sequence variant

584

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052254	hsa-let-7b-5p	CLASH	23622248
MIRT703462	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT703461	hsa-miR-4779	HITS-CLIP	23313552
MIRT703460	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT703459	hsa-miR-8060	HITS-CLIP	23313552
MIRT703458	hsa-miR-1225-3p	HITS-CLIP	23313552
MIRT703457	hsa-miR-1233-3p	HITS-CLIP	23313552
MIRT703456	hsa-miR-4641	HITS-CLIP	23313552
MIRT703455	hsa-miR-4266	HITS-CLIP	23313552
MIRT703454	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT508499	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT514914	hsa-miR-6134	PAR-CLIP	23446348
MIRT508498	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508497	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508496	hsa-miR-8085	PAR-CLIP	23446348
MIRT508495	hsa-miR-7977	PAR-CLIP	23446348
MIRT508494	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508493	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508492	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508491	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT508490	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT508489	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT508488	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT508487	hsa-miR-3689c	PAR-CLIP	23446348
MIRT508485	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT508486	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT508484	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT508483	hsa-miR-3122	PAR-CLIP	23446348
MIRT508482	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT508481	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT508480	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT508499	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT508498	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508497	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508496	hsa-miR-8085	PAR-CLIP	23446348
MIRT508495	hsa-miR-7977	PAR-CLIP	23446348
MIRT508494	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508493	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508492	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508491	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT508490	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT508489	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT508488	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT508487	hsa-miR-3689c	PAR-CLIP	23446348
MIRT508485	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT508486	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT508484	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT508483	hsa-miR-3122	PAR-CLIP	23446348
MIRT508482	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT508481	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT508480	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT736955	hsa-miR-607	Luciferase reporter assayWestern blottingqRT-PCR	33879631
MIRT703462	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT703461	hsa-miR-4779	HITS-CLIP	23313552
MIRT703460	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT703459	hsa-miR-8060	HITS-CLIP	23313552
MIRT703458	hsa-miR-1225-3p	HITS-CLIP	23313552
MIRT703457	hsa-miR-1233-3p	HITS-CLIP	23313552
MIRT703456	hsa-miR-4641	HITS-CLIP	23313552
MIRT703455	hsa-miR-4266	HITS-CLIP	23313552
MIRT703454	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT508499	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT514914	hsa-miR-6134	PAR-CLIP	23446348
MIRT508498	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508497	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508496	hsa-miR-8085	PAR-CLIP	23446348
MIRT508495	hsa-miR-7977	PAR-CLIP	23446348
MIRT508494	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508493	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508492	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508491	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT508490	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT508489	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT508488	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT508487	hsa-miR-3689c	PAR-CLIP	23446348
MIRT508485	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT508486	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT508484	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT508483	hsa-miR-3122	PAR-CLIP	23446348
MIRT508482	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT508481	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT508480	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT508499	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT508498	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508497	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508496	hsa-miR-8085	PAR-CLIP	23446348
MIRT508495	hsa-miR-7977	PAR-CLIP	23446348
MIRT508494	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508493	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508492	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508491	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT508490	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT508489	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT508488	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT508487	hsa-miR-3689c	PAR-CLIP	23446348
MIRT508485	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT508486	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT508484	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT508483	hsa-miR-3122	PAR-CLIP	23446348
MIRT508482	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT508481	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT508480	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT1005692	hsa-miR-1227	CLIP-seq
MIRT1005693	hsa-miR-1251	CLIP-seq
MIRT1005694	hsa-miR-1261	CLIP-seq
MIRT1005695	hsa-miR-1272	CLIP-seq
MIRT1005696	hsa-miR-1322	CLIP-seq
MIRT1005697	hsa-miR-1323	CLIP-seq
MIRT1005698	hsa-miR-148a	CLIP-seq
MIRT1005699	hsa-miR-148b	CLIP-seq
MIRT1005700	hsa-miR-152	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT1005702	hsa-miR-185	CLIP-seq
MIRT1005703	hsa-miR-2053	CLIP-seq
MIRT1005704	hsa-miR-2114	CLIP-seq
MIRT1005705	hsa-miR-2355-5p	CLIP-seq
MIRT1005706	hsa-miR-24	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT1005708	hsa-miR-2467-5p	CLIP-seq
MIRT1005709	hsa-miR-3120-5p	CLIP-seq
MIRT1005710	hsa-miR-3124-3p	CLIP-seq
MIRT1005711	hsa-miR-3152-3p	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT1005713	hsa-miR-3170	CLIP-seq
MIRT1005714	hsa-miR-3188	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT1005716	hsa-miR-3201	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT1005718	hsa-miR-3613-3p	CLIP-seq
MIRT1005719	hsa-miR-3646	CLIP-seq
MIRT1005720	hsa-miR-3662	CLIP-seq
MIRT1005721	hsa-miR-3665	CLIP-seq
MIRT1005722	hsa-miR-3672	CLIP-seq
MIRT1005723	hsa-miR-3679-3p	CLIP-seq
MIRT1005724	hsa-miR-3688-3p	CLIP-seq
MIRT1005725	hsa-miR-371-5p	CLIP-seq
MIRT1005726	hsa-miR-371b-5p	CLIP-seq
MIRT1005727	hsa-miR-377	CLIP-seq
MIRT1005728	hsa-miR-3915	CLIP-seq
MIRT1005729	hsa-miR-3921	CLIP-seq
MIRT1005730	hsa-miR-3928	CLIP-seq
MIRT1005731	hsa-miR-3929	CLIP-seq
MIRT1005732	hsa-miR-3975	CLIP-seq
MIRT1005733	hsa-miR-410	CLIP-seq
MIRT1005734	hsa-miR-4252	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005736	hsa-miR-4264	CLIP-seq
MIRT1005737	hsa-miR-4284	CLIP-seq
MIRT1005738	hsa-miR-4293	CLIP-seq
MIRT1005739	hsa-miR-4306	CLIP-seq
MIRT1005740	hsa-miR-4307	CLIP-seq
MIRT1005741	hsa-miR-4318	CLIP-seq
MIRT1005742	hsa-miR-4419b	CLIP-seq
MIRT1005743	hsa-miR-4438	CLIP-seq
MIRT1005744	hsa-miR-4446-3p	CLIP-seq
MIRT1005745	hsa-miR-4457	CLIP-seq
MIRT1005746	hsa-miR-4478	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT1005748	hsa-miR-4489	CLIP-seq
MIRT1005749	hsa-miR-4492	CLIP-seq
MIRT1005750	hsa-miR-4496	CLIP-seq
MIRT1005751	hsa-miR-4498	CLIP-seq
MIRT1005752	hsa-miR-4505	CLIP-seq
MIRT1005753	hsa-miR-4506	CLIP-seq
MIRT1005754	hsa-miR-4517	CLIP-seq
MIRT1005755	hsa-miR-451b	CLIP-seq
MIRT1005756	hsa-miR-4634	CLIP-seq
MIRT1005757	hsa-miR-4642	CLIP-seq
MIRT1005758	hsa-miR-4644	CLIP-seq
MIRT1005759	hsa-miR-4649-3p	CLIP-seq
MIRT1005760	hsa-miR-4653-5p	CLIP-seq
MIRT1005761	hsa-miR-4688	CLIP-seq
MIRT1005762	hsa-miR-4693-5p	CLIP-seq
MIRT1005763	hsa-miR-4711-3p	CLIP-seq
MIRT1005764	hsa-miR-4721	CLIP-seq
MIRT1005765	hsa-miR-4722-5p	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT1005767	hsa-miR-4730	CLIP-seq
MIRT1005768	hsa-miR-4738-3p	CLIP-seq
MIRT1005769	hsa-miR-4766-5p	CLIP-seq
MIRT1005770	hsa-miR-4789-3p	CLIP-seq
MIRT1005771	hsa-miR-4791	CLIP-seq
MIRT1005772	hsa-miR-4793-3p	CLIP-seq
MIRT1005773	hsa-miR-4797-3p	CLIP-seq
MIRT1005774	hsa-miR-485-5p	CLIP-seq
MIRT1005775	hsa-miR-488	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT1005777	hsa-miR-495	CLIP-seq
MIRT1005778	hsa-miR-508-5p	CLIP-seq
MIRT1005779	hsa-miR-511	CLIP-seq
MIRT1005780	hsa-miR-513b	CLIP-seq
MIRT1005781	hsa-miR-513c	CLIP-seq
MIRT1005782	hsa-miR-514b-5p	CLIP-seq
MIRT1005783	hsa-miR-520a-5p	CLIP-seq
MIRT1005784	hsa-miR-525-5p	CLIP-seq
MIRT1005785	hsa-miR-545	CLIP-seq
MIRT1005786	hsa-miR-548a-3p	CLIP-seq
MIRT1005787	hsa-miR-548e	CLIP-seq
MIRT1005788	hsa-miR-548f	CLIP-seq
MIRT1005789	hsa-miR-548o	CLIP-seq
MIRT1005790	hsa-miR-548v	CLIP-seq
MIRT1005791	hsa-miR-550a	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005793	hsa-miR-564	CLIP-seq
MIRT1005794	hsa-miR-569	CLIP-seq
MIRT1005795	hsa-miR-576-3p	CLIP-seq
MIRT1005796	hsa-miR-593	CLIP-seq
MIRT1005797	hsa-miR-596	CLIP-seq
MIRT1005798	hsa-miR-606	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1005800	hsa-miR-657	CLIP-seq
MIRT1005801	hsa-miR-658	CLIP-seq
MIRT1005802	hsa-miR-762	CLIP-seq
MIRT1005803	hsa-miR-890	CLIP-seq
MIRT1005804	hsa-miR-892a	CLIP-seq
MIRT1005805	hsa-miR-940	CLIP-seq
MIRT1005693	hsa-miR-1251	CLIP-seq
MIRT1998041	hsa-miR-1268	CLIP-seq
MIRT1998042	hsa-miR-1268b	CLIP-seq
MIRT1998043	hsa-miR-1293	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT1005704	hsa-miR-2114	CLIP-seq
MIRT1005706	hsa-miR-24	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT1998044	hsa-miR-3165	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT1005728	hsa-miR-3915	CLIP-seq
MIRT1005731	hsa-miR-3929	CLIP-seq
MIRT1005734	hsa-miR-4252	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005737	hsa-miR-4284	CLIP-seq
MIRT1005738	hsa-miR-4293	CLIP-seq
MIRT1998045	hsa-miR-4299	CLIP-seq
MIRT1005742	hsa-miR-4419b	CLIP-seq
MIRT1005746	hsa-miR-4478	CLIP-seq
MIRT1998046	hsa-miR-4483	CLIP-seq
MIRT1998047	hsa-miR-4486	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT1005750	hsa-miR-4496	CLIP-seq
MIRT1005759	hsa-miR-4649-3p	CLIP-seq
MIRT1005765	hsa-miR-4722-5p	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT1005768	hsa-miR-4738-3p	CLIP-seq
MIRT1005772	hsa-miR-4793-3p	CLIP-seq
MIRT1998048	hsa-miR-4797-5p	CLIP-seq
MIRT1005774	hsa-miR-485-5p	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT1998049	hsa-miR-542-3p	CLIP-seq
MIRT1998050	hsa-miR-548c-3p	CLIP-seq
MIRT1005791	hsa-miR-550a	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005793	hsa-miR-564	CLIP-seq
MIRT1998051	hsa-miR-585	CLIP-seq
MIRT1005796	hsa-miR-593	CLIP-seq
MIRT1005797	hsa-miR-596	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1005800	hsa-miR-657	CLIP-seq
MIRT1998052	hsa-miR-759	CLIP-seq
MIRT1005803	hsa-miR-890	CLIP-seq
MIRT1005805	hsa-miR-940	CLIP-seq
MIRT1998043	hsa-miR-1293	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT1005704	hsa-miR-2114	CLIP-seq
MIRT1005706	hsa-miR-24	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT2231662	hsa-miR-3117-3p	CLIP-seq
MIRT2231663	hsa-miR-3123	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT1998044	hsa-miR-3165	CLIP-seq
MIRT2231664	hsa-miR-3169	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT2231665	hsa-miR-3925-5p	CLIP-seq
MIRT1005731	hsa-miR-3929	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005737	hsa-miR-4284	CLIP-seq
MIRT1005742	hsa-miR-4419b	CLIP-seq
MIRT1005746	hsa-miR-4478	CLIP-seq
MIRT1998046	hsa-miR-4483	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT1005759	hsa-miR-4649-3p	CLIP-seq
MIRT1005765	hsa-miR-4722-5p	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT2231666	hsa-miR-4753-3p	CLIP-seq
MIRT2231667	hsa-miR-4759	CLIP-seq
MIRT1005774	hsa-miR-485-5p	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT1998050	hsa-miR-548c-3p	CLIP-seq
MIRT2231668	hsa-miR-548q	CLIP-seq
MIRT1005791	hsa-miR-550a	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005793	hsa-miR-564	CLIP-seq
MIRT2231669	hsa-miR-583	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1005803	hsa-miR-890	CLIP-seq
MIRT1005805	hsa-miR-940	CLIP-seq
MIRT1005692	hsa-miR-1227	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT1005706	hsa-miR-24	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT1005734	hsa-miR-4252	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005737	hsa-miR-4284	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT1005756	hsa-miR-4634	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT1005770	hsa-miR-4789-3p	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1998047	hsa-miR-4486	CLIP-seq
MIRT1998050	hsa-miR-548c-3p	CLIP-seq
MIRT2535555	hsa-miR-1197	CLIP-seq
MIRT2535556	hsa-miR-1207-5p	CLIP-seq
MIRT1005692	hsa-miR-1227	CLIP-seq
MIRT2535557	hsa-miR-1262	CLIP-seq
MIRT1998041	hsa-miR-1268	CLIP-seq
MIRT1998042	hsa-miR-1268b	CLIP-seq
MIRT2535558	hsa-miR-138	CLIP-seq
MIRT1005698	hsa-miR-148a	CLIP-seq
MIRT1005699	hsa-miR-148b	CLIP-seq
MIRT1005700	hsa-miR-152	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT2535559	hsa-miR-183	CLIP-seq
MIRT2535560	hsa-miR-186	CLIP-seq
MIRT1005704	hsa-miR-2114	CLIP-seq
MIRT2535561	hsa-miR-217	CLIP-seq
MIRT2535562	hsa-miR-2392	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT2535563	hsa-miR-3064-5p	CLIP-seq
MIRT2231662	hsa-miR-3117-3p	CLIP-seq
MIRT2535564	hsa-miR-3133	CLIP-seq
MIRT2535565	hsa-miR-3135	CLIP-seq
MIRT2535566	hsa-miR-3143	CLIP-seq
MIRT2535567	hsa-miR-3150b-3p	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT2535568	hsa-miR-3166	CLIP-seq
MIRT2535569	hsa-miR-3168	CLIP-seq
MIRT2231664	hsa-miR-3169	CLIP-seq
MIRT2535570	hsa-miR-3189-5p	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT2535571	hsa-miR-335	CLIP-seq
MIRT2535572	hsa-miR-3605-5p	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT1005718	hsa-miR-3613-3p	CLIP-seq
MIRT2535573	hsa-miR-3622a-5p	CLIP-seq
MIRT1005721	hsa-miR-3665	CLIP-seq
MIRT2535574	hsa-miR-3667-3p	CLIP-seq
MIRT1005722	hsa-miR-3672	CLIP-seq
MIRT2535575	hsa-miR-3675-5p	CLIP-seq
MIRT1005725	hsa-miR-371-5p	CLIP-seq
MIRT1005726	hsa-miR-371b-5p	CLIP-seq
MIRT2535576	hsa-miR-3926	CLIP-seq
MIRT1005731	hsa-miR-3929	CLIP-seq
MIRT1005734	hsa-miR-4252	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005736	hsa-miR-4264	CLIP-seq
MIRT2535577	hsa-miR-4274	CLIP-seq
MIRT2535578	hsa-miR-4279	CLIP-seq
MIRT2535579	hsa-miR-4283	CLIP-seq
MIRT1998045	hsa-miR-4299	CLIP-seq
MIRT2535580	hsa-miR-4303	CLIP-seq
MIRT2535581	hsa-miR-4419a	CLIP-seq
MIRT1005742	hsa-miR-4419b	CLIP-seq
MIRT2535582	hsa-miR-4443	CLIP-seq
MIRT2535583	hsa-miR-4453	CLIP-seq
MIRT2535584	hsa-miR-4455	CLIP-seq
MIRT2535585	hsa-miR-4456	CLIP-seq
MIRT2535586	hsa-miR-4470	CLIP-seq
MIRT2535587	hsa-miR-4471	CLIP-seq
MIRT2535588	hsa-miR-4474-3p	CLIP-seq
MIRT2535589	hsa-miR-4477a	CLIP-seq
MIRT1005746	hsa-miR-4478	CLIP-seq
MIRT1998047	hsa-miR-4486	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT2535590	hsa-miR-4488	CLIP-seq
MIRT1005748	hsa-miR-4489	CLIP-seq
MIRT2535591	hsa-miR-4495	CLIP-seq
MIRT2535592	hsa-miR-4501	CLIP-seq
MIRT2535593	hsa-miR-4504	CLIP-seq
MIRT1005752	hsa-miR-4505	CLIP-seq
MIRT2535594	hsa-miR-4509	CLIP-seq
MIRT2535595	hsa-miR-4510	CLIP-seq
MIRT2535596	hsa-miR-4538	CLIP-seq
MIRT1005759	hsa-miR-4649-3p	CLIP-seq
MIRT2535597	hsa-miR-4652-3p	CLIP-seq
MIRT2535598	hsa-miR-4659a-5p	CLIP-seq
MIRT2535599	hsa-miR-4659b-5p	CLIP-seq
MIRT2535600	hsa-miR-4675	CLIP-seq
MIRT2535601	hsa-miR-4682	CLIP-seq
MIRT2535602	hsa-miR-4694-3p	CLIP-seq
MIRT2535603	hsa-miR-4697-5p	CLIP-seq
MIRT2535604	hsa-miR-4701-3p	CLIP-seq
MIRT1005763	hsa-miR-4711-3p	CLIP-seq
MIRT2535605	hsa-miR-4720-3p	CLIP-seq
MIRT1005765	hsa-miR-4722-5p	CLIP-seq
MIRT2535606	hsa-miR-4725-5p	CLIP-seq
MIRT2535607	hsa-miR-4728-3p	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT2535608	hsa-miR-4736	CLIP-seq
MIRT2535609	hsa-miR-4737	CLIP-seq
MIRT2535610	hsa-miR-4741	CLIP-seq
MIRT2535611	hsa-miR-4744	CLIP-seq
MIRT2535612	hsa-miR-4747-5p	CLIP-seq
MIRT2231666	hsa-miR-4753-3p	CLIP-seq
MIRT2535613	hsa-miR-4758-3p	CLIP-seq
MIRT2231667	hsa-miR-4759	CLIP-seq
MIRT2535614	hsa-miR-4763-3p	CLIP-seq
MIRT2535615	hsa-miR-4769-3p	CLIP-seq
MIRT2535616	hsa-miR-4771	CLIP-seq
MIRT2535617	hsa-miR-4775	CLIP-seq
MIRT2535618	hsa-miR-4784	CLIP-seq
MIRT2535619	hsa-miR-4786-5p	CLIP-seq
MIRT2535620	hsa-miR-4793-5p	CLIP-seq
MIRT1005773	hsa-miR-4797-3p	CLIP-seq
MIRT1998048	hsa-miR-4797-5p	CLIP-seq
MIRT2535621	hsa-miR-4799-5p	CLIP-seq
MIRT2535622	hsa-miR-4804-3p	CLIP-seq
MIRT1005774	hsa-miR-485-5p	CLIP-seq
MIRT1005775	hsa-miR-488	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT2535623	hsa-miR-498	CLIP-seq
MIRT2535624	hsa-miR-504	CLIP-seq
MIRT1005780	hsa-miR-513b	CLIP-seq
MIRT2535625	hsa-miR-522	CLIP-seq
MIRT1998049	hsa-miR-542-3p	CLIP-seq
MIRT2535626	hsa-miR-548ae	CLIP-seq
MIRT2535627	hsa-miR-548aj	CLIP-seq
MIRT2535628	hsa-miR-548am	CLIP-seq
MIRT1998050	hsa-miR-548c-3p	CLIP-seq
MIRT2231668	hsa-miR-548q	CLIP-seq
MIRT2535629	hsa-miR-548s	CLIP-seq
MIRT2535630	hsa-miR-548u	CLIP-seq
MIRT2535631	hsa-miR-548x	CLIP-seq
MIRT2535632	hsa-miR-549	CLIP-seq
MIRT1005791	hsa-miR-550a	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005793	hsa-miR-564	CLIP-seq
MIRT2231669	hsa-miR-583	CLIP-seq
MIRT1998051	hsa-miR-585	CLIP-seq
MIRT1005796	hsa-miR-593	CLIP-seq
MIRT2535633	hsa-miR-600	CLIP-seq
MIRT2535634	hsa-miR-604	CLIP-seq
MIRT2535635	hsa-miR-609	CLIP-seq
MIRT2535636	hsa-miR-647	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1005800	hsa-miR-657	CLIP-seq
MIRT1998052	hsa-miR-759	CLIP-seq
MIRT2535637	hsa-miR-765	CLIP-seq
MIRT1005803	hsa-miR-890	CLIP-seq
MIRT1005804	hsa-miR-892a	CLIP-seq
MIRT1005805	hsa-miR-940	CLIP-seq
MIRT2535638	hsa-miR-944	CLIP-seq
MIRT2535556	hsa-miR-1207-5p	CLIP-seq
MIRT2535557	hsa-miR-1262	CLIP-seq
MIRT1998041	hsa-miR-1268	CLIP-seq
MIRT1998042	hsa-miR-1268b	CLIP-seq
MIRT2535558	hsa-miR-138	CLIP-seq
MIRT1005698	hsa-miR-148a	CLIP-seq
MIRT1005699	hsa-miR-148b	CLIP-seq
MIRT1005700	hsa-miR-152	CLIP-seq
MIRT1005701	hsa-miR-1827	CLIP-seq
MIRT2535559	hsa-miR-183	CLIP-seq
MIRT1005704	hsa-miR-2114	CLIP-seq
MIRT2535561	hsa-miR-217	CLIP-seq
MIRT2535562	hsa-miR-2392	CLIP-seq
MIRT1005707	hsa-miR-2467-3p	CLIP-seq
MIRT2535563	hsa-miR-3064-5p	CLIP-seq
MIRT2231662	hsa-miR-3117-3p	CLIP-seq
MIRT2535565	hsa-miR-3135	CLIP-seq
MIRT2535566	hsa-miR-3143	CLIP-seq
MIRT2535567	hsa-miR-3150b-3p	CLIP-seq
MIRT1005712	hsa-miR-3160-3p	CLIP-seq
MIRT2535568	hsa-miR-3166	CLIP-seq
MIRT2231664	hsa-miR-3169	CLIP-seq
MIRT2535570	hsa-miR-3189-5p	CLIP-seq
MIRT1005715	hsa-miR-3192	CLIP-seq
MIRT2535571	hsa-miR-335	CLIP-seq
MIRT2535572	hsa-miR-3605-5p	CLIP-seq
MIRT1005717	hsa-miR-3612	CLIP-seq
MIRT1005718	hsa-miR-3613-3p	CLIP-seq
MIRT1005721	hsa-miR-3665	CLIP-seq
MIRT1005722	hsa-miR-3672	CLIP-seq
MIRT2535575	hsa-miR-3675-5p	CLIP-seq
MIRT1005725	hsa-miR-371-5p	CLIP-seq
MIRT1005726	hsa-miR-371b-5p	CLIP-seq
MIRT2535576	hsa-miR-3926	CLIP-seq
MIRT1005731	hsa-miR-3929	CLIP-seq
MIRT1005735	hsa-miR-4257	CLIP-seq
MIRT1005736	hsa-miR-4264	CLIP-seq
MIRT2535577	hsa-miR-4274	CLIP-seq
MIRT2535578	hsa-miR-4279	CLIP-seq
MIRT2535579	hsa-miR-4283	CLIP-seq
MIRT1998045	hsa-miR-4299	CLIP-seq
MIRT2535581	hsa-miR-4419a	CLIP-seq
MIRT1005742	hsa-miR-4419b	CLIP-seq
MIRT2535582	hsa-miR-4443	CLIP-seq
MIRT2535583	hsa-miR-4453	CLIP-seq
MIRT2535585	hsa-miR-4456	CLIP-seq
MIRT2535586	hsa-miR-4470	CLIP-seq
MIRT2535587	hsa-miR-4471	CLIP-seq
MIRT2535588	hsa-miR-4474-3p	CLIP-seq
MIRT2535589	hsa-miR-4477a	CLIP-seq
MIRT1005746	hsa-miR-4478	CLIP-seq
MIRT1998047	hsa-miR-4486	CLIP-seq
MIRT1005747	hsa-miR-4487	CLIP-seq
MIRT2535590	hsa-miR-4488	CLIP-seq
MIRT1005748	hsa-miR-4489	CLIP-seq
MIRT2535591	hsa-miR-4495	CLIP-seq
MIRT2535592	hsa-miR-4501	CLIP-seq
MIRT2535593	hsa-miR-4504	CLIP-seq
MIRT1005752	hsa-miR-4505	CLIP-seq
MIRT2535595	hsa-miR-4510	CLIP-seq
MIRT2535596	hsa-miR-4538	CLIP-seq
MIRT1005759	hsa-miR-4649-3p	CLIP-seq
MIRT2535597	hsa-miR-4652-3p	CLIP-seq
MIRT2535598	hsa-miR-4659a-5p	CLIP-seq
MIRT2535599	hsa-miR-4659b-5p	CLIP-seq
MIRT2535600	hsa-miR-4675	CLIP-seq
MIRT2535602	hsa-miR-4694-3p	CLIP-seq
MIRT2535603	hsa-miR-4697-5p	CLIP-seq
MIRT2535604	hsa-miR-4701-3p	CLIP-seq
MIRT1005763	hsa-miR-4711-3p	CLIP-seq
MIRT2535605	hsa-miR-4720-3p	CLIP-seq
MIRT1005765	hsa-miR-4722-5p	CLIP-seq
MIRT2535606	hsa-miR-4725-5p	CLIP-seq
MIRT2535607	hsa-miR-4728-3p	CLIP-seq
MIRT1005766	hsa-miR-4728-5p	CLIP-seq
MIRT2535608	hsa-miR-4736	CLIP-seq
MIRT2535609	hsa-miR-4737	CLIP-seq
MIRT2535610	hsa-miR-4741	CLIP-seq
MIRT2535611	hsa-miR-4744	CLIP-seq
MIRT2535612	hsa-miR-4747-5p	CLIP-seq
MIRT2231666	hsa-miR-4753-3p	CLIP-seq
MIRT2535613	hsa-miR-4758-3p	CLIP-seq
MIRT2231667	hsa-miR-4759	CLIP-seq
MIRT2535614	hsa-miR-4763-3p	CLIP-seq
MIRT2535615	hsa-miR-4769-3p	CLIP-seq
MIRT2535616	hsa-miR-4771	CLIP-seq
MIRT2535618	hsa-miR-4784	CLIP-seq
MIRT2535619	hsa-miR-4786-5p	CLIP-seq
MIRT2535620	hsa-miR-4793-5p	CLIP-seq
MIRT1005773	hsa-miR-4797-3p	CLIP-seq
MIRT1998048	hsa-miR-4797-5p	CLIP-seq
MIRT2535622	hsa-miR-4804-3p	CLIP-seq
MIRT1005774	hsa-miR-485-5p	CLIP-seq
MIRT1005775	hsa-miR-488	CLIP-seq
MIRT1005776	hsa-miR-490-3p	CLIP-seq
MIRT2535623	hsa-miR-498	CLIP-seq
MIRT2535624	hsa-miR-504	CLIP-seq
MIRT1005780	hsa-miR-513b	CLIP-seq
MIRT2535625	hsa-miR-522	CLIP-seq
MIRT1998049	hsa-miR-542-3p	CLIP-seq
MIRT2535626	hsa-miR-548ae	CLIP-seq
MIRT2535627	hsa-miR-548aj	CLIP-seq
MIRT2535628	hsa-miR-548am	CLIP-seq
MIRT1998050	hsa-miR-548c-3p	CLIP-seq
MIRT2231668	hsa-miR-548q	CLIP-seq
MIRT2535629	hsa-miR-548s	CLIP-seq
MIRT2535630	hsa-miR-548u	CLIP-seq
MIRT2535631	hsa-miR-548x	CLIP-seq
MIRT2535632	hsa-miR-549	CLIP-seq
MIRT1005791	hsa-miR-550a	CLIP-seq
MIRT1005792	hsa-miR-558	CLIP-seq
MIRT1005793	hsa-miR-564	CLIP-seq
MIRT2231669	hsa-miR-583	CLIP-seq
MIRT1998051	hsa-miR-585	CLIP-seq
MIRT1005796	hsa-miR-593	CLIP-seq
MIRT2535634	hsa-miR-604	CLIP-seq
MIRT2535636	hsa-miR-647	CLIP-seq
MIRT1005799	hsa-miR-650	CLIP-seq
MIRT1005800	hsa-miR-657	CLIP-seq
MIRT1998052	hsa-miR-759	CLIP-seq
MIRT2535637	hsa-miR-765	CLIP-seq
MIRT2681222	hsa-miR-769-5p	CLIP-seq
MIRT1005803	hsa-miR-890	CLIP-seq
MIRT1005804	hsa-miR-892a	CLIP-seq
MIRT1005805	hsa-miR-940	CLIP-seq
MIRT2535638	hsa-miR-944	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
CUX1	Unknown	23341774

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	26458103, 28002401, 30197295
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	17991826
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	28002401
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006307	Process	DNA alkylation repair	IBA
GO:0006307	Process	DNA alkylation repair	IDA	18775698
GO:0006307	Process	DNA alkylation repair	IEA
GO:0008198	Function	Ferrous iron binding	IDA	20376003
GO:0010883	Process	Regulation of lipid storage	IBA
GO:0010883	Process	Regulation of lipid storage	IEA
GO:0010883	Process	Regulation of lipid storage	IMP	26287746
GO:0016180	Process	SnRNA processing	IDA	30197295
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016607	Component	Nuclear speck	IDA	22002720
GO:0016607	Component	Nuclear speck	IEA
GO:0016706	Function	2-oxoglutarate-dependent dioxygenase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035515	Function	Oxidative RNA demethylase activity	IDA	18775698, 22002720, 28002401, 30197295
GO:0035515	Function	Oxidative RNA demethylase activity	IEA
GO:0035516	Function	Broad specificity oxidative DNA demethylase activity	IBA
GO:0035516	Function	Broad specificity oxidative DNA demethylase activity	IDA	18775698, 20376003
GO:0035516	Function	Broad specificity oxidative DNA demethylase activity	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA
GO:0042245	Process	RNA repair	IBA
GO:0042245	Process	RNA repair	IDA	18775698
GO:0042245	Process	RNA repair	IEA
GO:0044065	Process	Regulation of respiratory system process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0060612	Process	Adipose tissue development	IEA
GO:0061157	Process	MRNA destabilization	IDA	28002401, 30197295
GO:0070350	Process	Regulation of white fat cell proliferation	IEA
GO:0090335	Process	Regulation of brown fat cell differentiation	IMP	26287746
GO:1990931	Function	MRNA N6-methyladenosine dioxygenase activity	IBA
GO:1990931	Function	MRNA N6-methyladenosine dioxygenase activity	IDA	25452335, 26457839, 30197295
GO:1990931	Function	MRNA N6-methyladenosine dioxygenase activity	IEA
GO:1990931	Function	MRNA N6-methyladenosine dioxygenase activity	IMP	26458103
GO:1990984	Function	TRNA demethylase activity	IDA	30197295

MIM	HGNC	e!Ensembl
610966	24678	ENSG00000140718

Q9C0B1

Protein name

Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'

Protein function

RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:

PDB

3LFM , 4CXW , 4CXX , 4CXY , 4IDZ , 4IE0 , 4IE4 , 4IE5 , 4IE6 , 4IE7 , 4QHO , 4QKN , 4ZS2 , 4ZS3 , 5DAB , 5F8P , 5ZMD , 6AEJ , 6AK4 , 6AKW , 7CKK , 7E8Z , 7WCV , 8IT9 , 9KNI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12933	FTO_NTD	36 → 325	FTO catalytic domain	Domain
PF12934	FTO_CTD	329 → 498	FTO C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary (PubMed:17434869, PubMed:17496892). Highly expressed in highly expressed in acute myeloid leukemias (AML) wit

Sequence

MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP

Sequence length

505

Interactions

View interactions

	Reactome
			Reversal of alkylation damage by DNA dioxygenases

134

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Body mass index quantitative trait locus 14	Likely pathogenic	rs2078991144	RCV003990737
Lethal polymalformative syndrome, Boissel type	Likely pathogenic; Pathogenic	rs121918214, rs781028867	RCV000001110 RCV000190415

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs113575052	RCV005913750
FTO-related disorder	Likely benign; Conflicting classifications of pathogenicity	rs752080961, rs144743617	RCV003903999 RCV003983247
Meniere disease	Uncertain significance	rs139577103, rs550932456, rs757468268	RCV004571969 RCV004571435 RCV004574909
OBESITY (BMIQ14), SUSCEPTIBILITY TO	risk factor	rs1421085	RCV000201907
Ovarian serous cystadenocarcinoma	Benign	rs113662449	RCV005894495
See cases	Uncertain significance	rs772076301	RCV002253116

Show/Hide Text Mining Associations (213)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abdominal Injuries	Associate	22504289, 31167208, 31810473
Abortion Habitual	Associate	25845303
Acromegaly	Associate	28913579, 37446150
Acute Coronary Syndrome	Associate	26740239
Adenoma	Associate	21317302
Adrenocortical Carcinoma	Associate	33725886
Age Related Hearing Impairment 1	Associate	37891192
Alcoholism	Associate	25265168, 26458734, 27905213
Alzheimer Disease	Associate	23251365
Amyotrophic lateral sclerosis 1	Associate	29216901
Anodontia	Associate	20339516
Anorexia Nervosa	Associate	22797368
Anxiety	Associate	25065638
Anxiety Disorders	Associate	25065638
Aortic Valve Stenosis	Associate	26431034
Arthritis Psoriatic	Associate	30733965, 35806402
Arthritis Rheumatoid	Associate	30166627, 32884942
Atherosclerosis	Associate	19587359, 20031593
Attention Deficit Disorder with Hyperactivity	Associate	23155456, 23512716
Body Weight	Associate	19828706, 21347432, 28659218, 36415696
Brain Diseases	Associate	20404173
Breast Neoplasms	Associate	21489227, 21688152, 23535733, 23593120, 24065098, 25862352, 26146447, 26722548, 27053251, 28377418, 32805088, 33342785, 33634577, 33785833, 34076564 View all (9 more)
Bulimia	Associate	26193063, 28282466
Bulimia Nervosa	Associate	22797368
Carcinogenesis	Associate	21347432, 32053666, 33634966, 34087991, 35524932
Carcinogenesis	Inhibit	35858900
Carcinoma Hepatocellular	Associate	32631107
Carcinoma Hepatocellular	Stimulate	34221187
Carcinoma Non Small Cell Lung	Associate	34367534, 34812534, 34998823, 37848553, 37919739
Carcinoma Pancreatic Ductal	Associate	37914721, 40262723
Carcinoma Renal Cell	Associate	37626050, 38164857, 38270643
Cardiomyopathies	Associate	37041267
Cardiomyopathy Restrictive	Associate	22016090
Cardiovascular Diseases	Associate	19910641, 21146673, 22791637, 23551410, 24289790, 26431034, 26878843, 28913579, 32271440, 34537236, 37446150
Carotid Artery Diseases	Associate	36894991
Carotid Stenosis	Associate	36894991
Cerebral Palsy	Stimulate	35705018
Chemical and Drug Induced Liver Injury	Associate	30111348
Chromosome 16 trisomy 16q	Associate	20186806
Cognition Disorders	Associate	30111348
Cognitive Dysfunction	Associate	23136261, 29529147
Colorectal Neoplasms	Associate	20339516, 30556861, 32053666, 33741917, 37543622, 39849877
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	28282466
Conversion Disorder	Associate	37500688
Coronary Artery Disease	Associate	26878843, 28167353
Coronary Disease	Associate	26878843
COVID 19	Associate	34225491
Coxa Magna	Associate	35706030
Crohn Disease	Associate	36595818
Cystic Fibrosis	Associate	39260370
Death	Associate	19214238
Delayed Emergence from Anesthesia	Associate	23628854, 24622803
Depressive Disorder	Associate	25102252, 28765304
Diabetes Gestational	Associate	28699988, 30371117, 31825269, 32390949, 33953693
Diabetes Gestational	Inhibit	32390949
Diabetes Mellitus	Associate	17434869, 18239580, 18346983, 18535549, 18599522, 19008344, 20161779, 20502638, 20548773, 21146673, 21266646, 21868005, 22421923, 23185617, 23236435 View all (15 more)
Diabetes Mellitus Type 2	Associate	17463248, 17786212, 18335027, 18346983, 18426861, 18469204, 18487448, 18535549, 18598350, 18599522, 18694974, 18787525, 19005641, 19008344, 19056611 View all (65 more)
Diabetic Angiopathies	Associate	39343042
Diabetic Nephropathies	Associate	31568687
Diabetic Retinopathy	Associate	29410390
Disorders of Excessive Somnolence	Associate	25724814
Disruptive Impulse Control and Conduct Disorders	Associate	23155456, 24863145, 31772290, 37223038
Drug Related Side Effects and Adverse Reactions	Associate	32299393
Dyslipidemias	Associate	27173266, 33348678, 38161971, 40114142
Embolism Fat	Associate	18535549, 19259258, 22504289
Endometrial Neoplasms	Associate	20647405, 21347432, 21976109, 34347888, 35731272
Endometriosis	Associate	36672827, 37871609
Epilepsy	Associate	22948233
Esophageal Squamous Cell Carcinoma	Associate	35524932
Essential Hypertension	Associate	23691120
Fatty Liver	Associate	25367448, 28116842, 32848374
Feeding and Eating Disorders	Associate	19828706, 22797368, 23155456, 25888059, 28282466, 31852448, 37752455
Fetal Growth Retardation	Associate	33729310
Fractures Bone	Associate	35090337, 39336743
Fragile X Syndrome	Associate	39336743
Gestational Weight Gain	Associate	25510251, 35268025
Glioblastoma	Associate	33412003, 39216042
Glioma	Associate	36123877, 36718644
Glucocorticoid Receptor Deficiency	Associate	30026463
Glucose Intolerance	Associate	19180072, 22504289
GSD IV Neuromuscular Form Fatal Perinatal	Associate	22030987
Heart Diseases	Associate	34713923, 38064210
Helicobacter Infections	Associate	36918410
Hepatoblastoma	Associate	35311451
Hereditary Angioedema Type III	Associate	22901973
HIV Infections	Associate	28116842
Hypercholesterolemia	Associate	36183687
Hyperglycemia	Associate	22504289, 29315078, 34454619
Hyperphagia	Associate	31388097
Hypertension	Associate	21146673, 22132335, 23691120, 23824655, 23849767, 34134115, 37181702, 37697388
Hypoglycemia	Associate	23990951
Hypoxia	Associate	34713923
Hypoxia	Inhibit	36718644
Infertility	Associate	26820768, 37871609
Inflammation	Associate	21246032, 24289790, 36980809
Inflammation	Inhibit	34537236
Insulin Resistance	Associate	20377915, 20858286, 21919686, 22504289, 22791637, 22791750, 24289790, 25367448, 25761503, 27759977, 29764479, 30733965, 31200723, 32495892, 34063412, 37111057, 37710301, 40055326 View all (3 more)
Intervertebral Disc Degeneration	Associate	24304927, 30099472, 34812958
Intestinal Pseudo Obstruction	Associate	36591842
Ischemic Attack Transient	Associate	21921652
Kidney Failure Chronic	Associate	21788373
Latent Autoimmune Diabetes in Adults	Associate	31125083
Leiomyosarcoma	Associate	37175660
Leukemia	Associate	28017614, 32531268
Leukemia Myeloid Acute	Inhibit	28017614
Leukemia Myeloid Acute	Associate	30991023, 33412003, 35311451
Lipid Metabolism Disorders	Associate	32955223, 34063412
Livedoid Vasculopathy	Associate	39343042
Liver Diseases	Associate	25367448, 36371078
Lupus Erythematosus Systemic	Inhibit	32685056
Lymphatic Metastasis	Associate	32805088
Mandibular Nerve Injuries	Associate	34814294
MASS syndrome	Associate	25888059, 25929371, 26886906
Melanoma	Associate	23455637, 23539184
Memory Disorders	Associate	23551410
Mental Disorders	Associate	25265168
Metabolic Diseases	Associate	21379325, 25888059, 30091536, 32050935, 32955223, 33729310, 34713923, 36415696
Metabolic Syndrome	Associate	18339204, 18346983, 21146673, 21796137, 22457394, 23890480, 25367448, 26740239, 28738793, 28915859, 30091536, 30442880, 32028392, 34208143, 34454619, 38064210, 38201907 View all (2 more)
Microcephaly	Associate	26740239
Microphthalmia Syndromic 10	Associate	20404173, 26337140
Miller McKusick Malvaux Syndrome (3M Syndrome)	Associate	30111348
Mouth Neoplasms	Associate	34378866
Multiple Myeloma	Associate	36177774
Multiple Sclerosis	Associate	31836807
Muscle Neoplasms	Associate	40056411
Myocardial Infarction	Associate	20031593, 36061306
Myopia	Associate	37181702
Myotonic Dystrophy	Associate	28977211
Neoplasm Metastasis	Associate	30637548, 35524932, 35858900, 37848553, 37919739, 40022434
Neoplasm Metastasis	Inhibit	38082402
Neoplasms	Associate	20339516, 20976066, 22384102, 30953473, 32299393, 32531268, 32805088, 33412003, 33684100, 34378866, 34787056, 34998823, 35067178, 35311451, 35524932 View all (8 more)
Neoplasms	Stimulate	33299884
Neoplasms	Inhibit	34499008, 36177774, 36718644, 38082402
Neoplasms Adipose Tissue	Associate	18842783, 19016587, 19322589, 19543202, 19793853, 19798072, 19828706, 19833892, 20377915, 20379142, 20502638, 20717169, 21102551, 21544599, 21593801 View all (25 more)
Nervous System Diseases	Associate	19214238
Neural Tube Defects	Inhibit	23132673
Neural Tube Defects	Associate	23132673
Non alcoholic Fatty Liver Disease	Associate	35654975, 36627697, 37984229
Obesity	Associate	17434869, 17658951, 17786212, 17996046, 18048838, 18159244, 18218107, 18239580, 18335027, 18339204, 18346983, 18379722, 18426866, 18469204, 18487448 View all (402 more)
Obesity Abdominal	Associate	23424664, 33612620
Obesity Maternal	Associate	23784909
Obesity Metabolically Benign	Associate	32612360
Obesity Morbid	Associate	31852448
Oculocutaneous albinism type 2	Associate	26726774
Osteoarthritis	Associate	22763110, 22956599, 23921993, 29606151, 34812958, 37217897
Osteoarthritis Knee	Associate	23921993, 36089590, 38442374
Osteoporosis	Associate	22125610, 35090337, 35511874, 36034449, 36967763, 39336743
Osteoporotic Fractures	Associate	35090337
Osteosarcoma	Associate	33952279
Ovarian Diseases	Inhibit	37871609
Ovarian Neoplasms	Associate	37674251, 38025760
Overweight	Associate	18799002, 19543202, 19812171, 21347432, 22457394, 22504289, 23155422, 23347264, 23890480, 23921993, 24622803, 25102252, 25137265, 26445370, 27154418 View all (26 more)
Pancreatic Neoplasms	Associate	21445555, 23835106, 35879877, 37605223, 38057853
Pancreatic Neoplasms	Stimulate	35404184
Parental Death	Associate	27196523
Pediatric Obesity	Associate	22030988
Personality Disorders	Associate	31772290
Pigmentation Disorders	Associate	23539184
Polycystic Ovary Syndrome	Associate	20092643, 21283731, 22389004, 23840863, 25592819, 26032905, 26722565, 29463151, 30496407, 30596735, 32050935, 33914321, 37710301, 40258223
Pre Eclampsia	Associate	22132335, 31825269, 37160708
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Stimulate	39251964
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	39316719
Prediabetic State	Associate	35757166, 36980809
Pregnancy Complications	Associate	27768255
Pregnancy in Diabetics	Associate	27768255
Premature Birth	Associate	27768255
Prenatal Exposure Delayed Effects	Associate	30111348
Pressure Ulcer	Associate	26324055
Prostatic Neoplasms	Associate	20976066, 23193118, 34787056, 37647111
Protein Energy Malnutrition	Associate	34713923
Psoriasis	Associate	30733965
Pulmonary Arterial Hypertension	Associate	28977211, 36888776
Pulmonary Disease Chronic Obstructive	Associate	32961012, 33057025
Pulmonary Embolism	Associate	25161014
Reflex Abnormal	Associate	21544599
Renal Insufficiency Chronic	Associate	21788373, 34134115
Reproductive Tract Infections	Associate	34784930
Sarcopenia	Associate	32076017, 34302448
Schizophrenia	Associate	23236985
Sepsis	Associate	38470396
Simpson Golabi Behmel syndrome	Associate	27394708, 30967578
Sjogren's Syndrome	Associate	29504848
Skin Diseases	Associate	22377712
Sleep Apnea Obstructive	Associate	30600310, 33243845
Spinal Cord Injuries	Inhibit	34814294
Squamous Cell Carcinoma of Head and Neck	Associate	31519943
Squamous Cell Carcinoma of Head and Neck	Stimulate	34378866
Stomach Neoplasms	Associate	30637548, 33393595, 35730319, 36918410, 38082402, 38200441
Stroke	Associate	21921652
Substance Related Disorders	Associate	26354923
Temporomandibular Joint Dysfunction Syndrome	Associate	34812958
Thinness	Associate	29677190
Thyroid Cancer Papillary	Associate	27207655, 34837923
Thyroid Cancer Papillary	Inhibit	35090515
Thyroid Hormone Metabolism Abnormal	Associate	27920511
Thyroid Neoplasms	Associate	33285050, 36389678
Tooth Loss	Associate	19828706
Triple Negative Breast Neoplasms	Associate	40022434
Tuberculosis	Associate	25377722
Tuberculosis Pulmonary	Associate	25377722, 28357924, 36619747
Urinary Bladder Neoplasms	Inhibit	32299393
Urinary Bladder Neoplasms	Stimulate	33634966, 37538000
Urinary Bladder Neoplasms	Associate	34499008
Uterine Cervical Neoplasms	Associate	34564982
Uterine Neoplasms	Associate	37175660
Vascular Diseases	Associate	27768255, 39343042
Vascular Ring	Associate	35712246
Venous Thromboembolism	Associate	28301549, 28528403, 29325734
Venous Thrombosis	Associate	25161014
Ventricular Remodeling	Associate	39457420
Virilism	Associate	21575951
Weight Gain	Associate	22030987, 22030988, 22421893, 23216922, 23840443, 23922112, 24130335, 25099543, 25278160, 25510251, 25522302, 25724814, 26138810, 29138452, 29469022, 37223038, 38066615, 40056411 View all (3 more)
Weight Loss	Associate	18535549, 19798072, 22016090, 22030987, 22179955, 22421893, 22891219, 24622803, 24798613, 25137265, 25724814, 25761503, 27260224, 27804228, 28659218 View all (9 more)

FTO (FTO alpha-ketoglutarate dependent dioxygenase)