Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79054
Gene name Gene Name - the full gene name approved by the HGNC.	Transient receptor potential cation channel subfamily M member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRPM8
Synonyms (NCBI Gene) Gene synonyms aliases	LTRPC6, LTrpC-6, TRPP8, trp-p8
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q37.1

Show/Hide all(107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018725	hsa-miR-335-5p	Microarray	18185580
MIRT1457570	hsa-miR-122	CLIP-seq
MIRT1457571	hsa-miR-1237	CLIP-seq
MIRT1457572	hsa-miR-1245	CLIP-seq
MIRT1457573	hsa-miR-1293	CLIP-seq
MIRT1457574	hsa-miR-1913	CLIP-seq
MIRT1457575	hsa-miR-205	CLIP-seq
MIRT1457576	hsa-miR-23a	CLIP-seq
MIRT1457577	hsa-miR-23b	CLIP-seq
MIRT1457578	hsa-miR-23c	CLIP-seq
MIRT1457579	hsa-miR-3121-3p	CLIP-seq
MIRT1457580	hsa-miR-3135b	CLIP-seq
MIRT1457581	hsa-miR-3148	CLIP-seq
MIRT1457582	hsa-miR-3159	CLIP-seq
MIRT1457583	hsa-miR-324-3p	CLIP-seq
MIRT1457584	hsa-miR-338-5p	CLIP-seq
MIRT1457585	hsa-miR-3614-3p	CLIP-seq
MIRT1457586	hsa-miR-3652	CLIP-seq
MIRT1457587	hsa-miR-3664-5p	CLIP-seq
MIRT1457588	hsa-miR-3688-3p	CLIP-seq
MIRT1457589	hsa-miR-3942-5p	CLIP-seq
MIRT1457590	hsa-miR-4294	CLIP-seq
MIRT1457591	hsa-miR-4303	CLIP-seq
MIRT1457592	hsa-miR-4430	CLIP-seq
MIRT1457593	hsa-miR-4433	CLIP-seq
MIRT1457594	hsa-miR-4483	CLIP-seq
MIRT1457595	hsa-miR-4639-3p	CLIP-seq
MIRT1457596	hsa-miR-4651	CLIP-seq
MIRT1457597	hsa-miR-4682	CLIP-seq
MIRT1457598	hsa-miR-4700-3p	CLIP-seq
MIRT1457599	hsa-miR-4703-5p	CLIP-seq
MIRT1457600	hsa-miR-4707-5p	CLIP-seq
MIRT1457601	hsa-miR-4735-5p	CLIP-seq
MIRT1457602	hsa-miR-4777-3p	CLIP-seq
MIRT1457603	hsa-miR-4789-3p	CLIP-seq
MIRT1457604	hsa-miR-5095	CLIP-seq
MIRT1457605	hsa-miR-5096	CLIP-seq
MIRT1457606	hsa-miR-548aa	CLIP-seq
MIRT1457607	hsa-miR-548ac	CLIP-seq
MIRT1457608	hsa-miR-548d-3p	CLIP-seq
MIRT1457609	hsa-miR-548z	CLIP-seq
MIRT1457610	hsa-miR-608	CLIP-seq
MIRT1457611	hsa-miR-643	CLIP-seq
MIRT1457612	hsa-miR-651	CLIP-seq
MIRT1457613	hsa-miR-767-5p	CLIP-seq
MIRT1457614	hsa-miR-876-3p	CLIP-seq
MIRT1457572	hsa-miR-1245	CLIP-seq
MIRT2137216	hsa-miR-1256	CLIP-seq
MIRT2137217	hsa-miR-1281	CLIP-seq
MIRT1457574	hsa-miR-1913	CLIP-seq
MIRT2137218	hsa-miR-1915	CLIP-seq
MIRT2137219	hsa-miR-3187-3p	CLIP-seq
MIRT1457583	hsa-miR-324-3p	CLIP-seq
MIRT2137220	hsa-miR-338-3p	CLIP-seq
MIRT2137221	hsa-miR-3663-5p	CLIP-seq
MIRT2137222	hsa-miR-3672	CLIP-seq
MIRT1457589	hsa-miR-3942-5p	CLIP-seq
MIRT2137223	hsa-miR-4420	CLIP-seq
MIRT2137224	hsa-miR-4435	CLIP-seq
MIRT2137225	hsa-miR-4461	CLIP-seq
MIRT2137226	hsa-miR-4530	CLIP-seq
MIRT2137227	hsa-miR-4645-5p	CLIP-seq
MIRT2137228	hsa-miR-4673	CLIP-seq
MIRT2137229	hsa-miR-4701-5p	CLIP-seq
MIRT1457599	hsa-miR-4703-5p	CLIP-seq
MIRT2137230	hsa-miR-4726-3p	CLIP-seq
MIRT2137231	hsa-miR-4755-3p	CLIP-seq
MIRT2137232	hsa-miR-4772-3p	CLIP-seq
MIRT2137233	hsa-miR-548s	CLIP-seq
MIRT2137234	hsa-miR-588	CLIP-seq
MIRT2137235	hsa-miR-659	CLIP-seq
MIRT1457570	hsa-miR-122	CLIP-seq
MIRT2137217	hsa-miR-1281	CLIP-seq
MIRT2137218	hsa-miR-1915	CLIP-seq
MIRT1457580	hsa-miR-3135b	CLIP-seq
MIRT2357966	hsa-miR-3180-5p	CLIP-seq
MIRT2137219	hsa-miR-3187-3p	CLIP-seq
MIRT2357967	hsa-miR-3199	CLIP-seq
MIRT2357968	hsa-miR-320a	CLIP-seq
MIRT2357969	hsa-miR-320b	CLIP-seq
MIRT2357970	hsa-miR-320c	CLIP-seq
MIRT2357971	hsa-miR-320d	CLIP-seq
MIRT2357972	hsa-miR-320e	CLIP-seq
MIRT2357973	hsa-miR-3646	CLIP-seq
MIRT1457586	hsa-miR-3652	CLIP-seq
MIRT2137221	hsa-miR-3663-5p	CLIP-seq
MIRT2357974	hsa-miR-3919	CLIP-seq
MIRT2357975	hsa-miR-3978	CLIP-seq
MIRT2137223	hsa-miR-4420	CLIP-seq
MIRT2357976	hsa-miR-4429	CLIP-seq
MIRT1457592	hsa-miR-4430	CLIP-seq
MIRT2137224	hsa-miR-4435	CLIP-seq
MIRT2357977	hsa-miR-4659a-5p	CLIP-seq
MIRT2357978	hsa-miR-4659b-5p	CLIP-seq
MIRT2137229	hsa-miR-4701-5p	CLIP-seq
MIRT1457600	hsa-miR-4707-5p	CLIP-seq
MIRT2357979	hsa-miR-4716-5p	CLIP-seq
MIRT2137230	hsa-miR-4726-3p	CLIP-seq
MIRT2137231	hsa-miR-4755-3p	CLIP-seq
MIRT2137232	hsa-miR-4772-3p	CLIP-seq
MIRT2357980	hsa-miR-4776-3p	CLIP-seq
MIRT2357981	hsa-miR-4781-3p	CLIP-seq
MIRT2357982	hsa-miR-520a-5p	CLIP-seq
MIRT2357983	hsa-miR-525-5p	CLIP-seq
MIRT2137233	hsa-miR-548s	CLIP-seq
MIRT2137234	hsa-miR-588	CLIP-seq
MIRT2137235	hsa-miR-659	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	TAS
GO:0005515	Function	Protein binding	IPI	25559186
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	25559186
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0009266	Process	Response to temperature stimulus	IEA
GO:0009409	Process	Response to cold	IEA
GO:0009409	Process	Response to cold	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0044853	Component	Plasma membrane raft	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046873	Function	Metal ion transmembrane transporter activity	IEA
GO:0050955	Process	Thermoception	IBA
GO:0050955	Process	Thermoception	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IBA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0099604	Function	Ligand-gated calcium channel activity	IBA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IBA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	22241835

MIM	HGNC	e!Ensembl
606678	17961	ENSG00000144481

Protein

UniProt ID

Q7Z2W7

Protein name

Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)

Protein function

Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Act

PDB

8BDC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18139	LSDAT_euk	115 → 387	SLOG in TRPM	Family
PF00520	Ion_trans	736 → 991	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:12858355, ECO:0000269|PubMed:16174775, ECO:00002

Sequence

MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
RFRQLDTKLNDLKGLLKEIANKIK

Sequence length

1104

Interactions

View interactions

	KEGG		Reactome
	Inflammatory mediator regulation of TRP channels		TRP channels

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset), Asthma	N/A	N/A	GWAS
Dermatitis	Atopic dermatitis (moderate to severe)	N/A	N/A	GWAS
Melanoma	Melanoma	N/A	N/A	GWAS
Migraine with Aura	Migraine with aura	N/A	N/A	GWAS

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	33955429
Asthma	Associate	18441098
Asthma Occupational	Associate	28255167
Atrial Fibrillation	Associate	28839241
Breast Neoplasms	Associate	20482834, 33020304
Breast Neoplasms	Stimulate	24903376
Carcinogenesis	Associate	22555807, 25128062
Carcinoma Pancreatic Ductal	Associate	28857015
Cleft Lip	Stimulate	37203044
Congenital thrombotic disease due to Protein C deficiency	Associate	31273254
Diabetic Neuropathies	Associate	17521436, 36430572
Drug Related Side Effects and Adverse Reactions	Associate	24641366
Dry Eye Syndromes	Associate	36796252
Esophageal Neoplasms	Stimulate	31519770
Glioblastoma	Associate	26088448, 39581355
Hyperalgesia	Associate	17889683, 31842742
Hypertension	Associate	24165912
Hypertension Pulmonary	Associate	27789940
Inflammation	Associate	18441098, 28255167
Liver Failure	Associate	28025641
Melanoma	Associate	18524940, 22897572, 24641366
Metabolic Syndrome	Associate	25967713
Migraine Disorders	Associate	21666692, 22683712, 24674449, 24852292, 26660531, 29723195, 31842742, 31873179
Migraine with Aura	Associate	26660531
Neoplasm Metastasis	Associate	24391455
Neoplasm Metastasis	Stimulate	24903376, 29860264
Neoplasms	Associate	18524940, 18955132, 20482834, 22128173, 22555807, 23251635, 23391636, 24391455, 25128062, 28039451, 28857015, 29860264, 31519770, 33020304, 36012311
Neoplasms	Stimulate	24641366
Neuralgia	Associate	21666692
Obesity	Associate	27421018
Osteosarcoma	Associate	24391455
Pain	Associate	24975826, 31873179, 35806193, 37203044
Pancreatic Neoplasms	Associate	20605675, 22555807, 28857015, 29860264, 36012311
Pancreatitis	Associate	22555807
Peripheral Nervous System Diseases	Associate	35806193
Prostatic Diseases	Associate	33955429
Prostatic Hyperplasia	Associate	37781794
Prostatic Neoplasms	Associate	17510704, 18955132, 19234481, 21623387, 22128173, 22437241, 23251635, 23391636, 24517338, 25980497, 28039451, 28550110, 31501416, 33955429, 35570407, 37781794 View all (1 more)
Prostatic Neoplasms Castration Resistant	Associate	22437241
Prostatitis	Associate	25980497, 31501416
Pulmonary Disease Chronic Obstructive	Associate	27789940
Pulpitis	Associate	17889683
Rhinitis	Associate	28767579
Rufous oculocutaneous albinism	Associate	33955429
Signs and Symptoms	Associate	31842742
Small Fiber Neuropathy	Associate	36430572
Tertiary Lymphoid Structures	Associate	33955429
Urinary Bladder Neoplasms	Associate	25128062
Wounds and Injuries	Associate	17521436

TRPM8 (transient receptor potential cation channel subfamily M member 8)