Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79037
Gene name	PVR related immunoglobulin domain containing
Gene symbol	PVRIG
Synonyms (NCBI Gene)	C7orf15CD112R
Chromosome	7
Chromosome location	7q22.1

149

Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT614344	hsa-miR-603	HITS-CLIP	19536157
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	19536157
MIRT614341	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT614339	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT614338	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT614344	hsa-miR-603	HITS-CLIP	19536157
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	19536157
MIRT614341	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT614339	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT614338	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT614344	hsa-miR-603	HITS-CLIP	19536157
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	19536157
MIRT614341	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT614339	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT614338	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT614344	hsa-miR-603	HITS-CLIP	19536157
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	19536157
MIRT614341	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT614339	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT614338	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT614344	hsa-miR-603	HITS-CLIP	23824327
MIRT614343	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT614342	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT614341	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT614340	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT614339	hsa-miR-668-3p	HITS-CLIP	23824327
MIRT614338	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1278182	hsa-miR-103a	CLIP-seq
MIRT1278183	hsa-miR-107	CLIP-seq
MIRT1278184	hsa-miR-1228	CLIP-seq
MIRT1278185	hsa-miR-1301	CLIP-seq
MIRT1278186	hsa-miR-1914	CLIP-seq
MIRT1278187	hsa-miR-203	CLIP-seq
MIRT1278188	hsa-miR-214	CLIP-seq
MIRT1278189	hsa-miR-2861	CLIP-seq
MIRT1278190	hsa-miR-3136-5p	CLIP-seq
MIRT1278191	hsa-miR-3619-5p	CLIP-seq
MIRT1278192	hsa-miR-3665	CLIP-seq
MIRT1278193	hsa-miR-377	CLIP-seq
MIRT1278194	hsa-miR-3936	CLIP-seq
MIRT1278195	hsa-miR-4435	CLIP-seq
MIRT1278196	hsa-miR-4439	CLIP-seq
MIRT1278197	hsa-miR-4513	CLIP-seq
MIRT1278198	hsa-miR-5047	CLIP-seq
MIRT1278199	hsa-miR-541	CLIP-seq
MIRT1278200	hsa-miR-548a-5p	CLIP-seq
MIRT1278201	hsa-miR-548ab	CLIP-seq
MIRT1278202	hsa-miR-548ak	CLIP-seq
MIRT1278203	hsa-miR-548b-5p	CLIP-seq
MIRT1278204	hsa-miR-548c-5p	CLIP-seq
MIRT1278205	hsa-miR-548d-5p	CLIP-seq
MIRT1278206	hsa-miR-548h	CLIP-seq
MIRT1278207	hsa-miR-548i	CLIP-seq
MIRT1278208	hsa-miR-548j	CLIP-seq
MIRT1278209	hsa-miR-548k	CLIP-seq
MIRT1278210	hsa-miR-548l	CLIP-seq
MIRT1278211	hsa-miR-548w	CLIP-seq
MIRT1278212	hsa-miR-548y	CLIP-seq
MIRT1278213	hsa-miR-559	CLIP-seq
MIRT1278214	hsa-miR-654-5p	CLIP-seq
MIRT1278215	hsa-miR-761	CLIP-seq
MIRT1278188	hsa-miR-214	CLIP-seq
MIRT1278189	hsa-miR-2861	CLIP-seq
MIRT2307616	hsa-miR-3153	CLIP-seq
MIRT2307617	hsa-miR-3192	CLIP-seq
MIRT1278191	hsa-miR-3619-5p	CLIP-seq
MIRT1278192	hsa-miR-3665	CLIP-seq
MIRT2307618	hsa-miR-3689a-3p	CLIP-seq
MIRT2307619	hsa-miR-3689c	CLIP-seq
MIRT1278195	hsa-miR-4435	CLIP-seq
MIRT2307620	hsa-miR-4459	CLIP-seq
MIRT2307621	hsa-miR-4695-5p	CLIP-seq
MIRT2307622	hsa-miR-4716-3p	CLIP-seq
MIRT2307623	hsa-miR-4728-5p	CLIP-seq
MIRT1278199	hsa-miR-541	CLIP-seq
MIRT2307624	hsa-miR-625	CLIP-seq
MIRT1278214	hsa-miR-654-5p	CLIP-seq
MIRT2307625	hsa-miR-661	CLIP-seq
MIRT2307626	hsa-miR-665	CLIP-seq
MIRT1278215	hsa-miR-761	CLIP-seq
MIRT1278184	hsa-miR-1228	CLIP-seq
MIRT2457499	hsa-miR-1302	CLIP-seq
MIRT1278186	hsa-miR-1914	CLIP-seq
MIRT1278187	hsa-miR-203	CLIP-seq
MIRT1278188	hsa-miR-214	CLIP-seq
MIRT1278189	hsa-miR-2861	CLIP-seq
MIRT2307617	hsa-miR-3192	CLIP-seq
MIRT1278191	hsa-miR-3619-5p	CLIP-seq
MIRT1278192	hsa-miR-3665	CLIP-seq
MIRT2307618	hsa-miR-3689a-3p	CLIP-seq
MIRT2307619	hsa-miR-3689c	CLIP-seq
MIRT1278193	hsa-miR-377	CLIP-seq
MIRT2457500	hsa-miR-4298	CLIP-seq
MIRT1278195	hsa-miR-4435	CLIP-seq
MIRT2307620	hsa-miR-4459	CLIP-seq
MIRT2307621	hsa-miR-4695-5p	CLIP-seq
MIRT2307622	hsa-miR-4716-3p	CLIP-seq
MIRT2307623	hsa-miR-4728-5p	CLIP-seq
MIRT2457501	hsa-miR-4786-5p	CLIP-seq
MIRT1278199	hsa-miR-541	CLIP-seq
MIRT2307624	hsa-miR-625	CLIP-seq
MIRT1278214	hsa-miR-654-5p	CLIP-seq
MIRT2307625	hsa-miR-661	CLIP-seq
MIRT2307626	hsa-miR-665	CLIP-seq
MIRT2457502	hsa-miR-668	CLIP-seq
MIRT1278215	hsa-miR-761	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26755705, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26755705
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0019902	Function	Phosphatase binding	IPI	26755705
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038023	Function	Signaling receptor activity	IMP	26755705
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IBA
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IEA
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IMP	26755705

MIM	HGNC	e!Ensembl
617012	32190	ENSG00000213413

Q6DKI7

Protein name

Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein)

Protein function

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubM

PDB

8X6B

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ an

Sequence

MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTI
RCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEG
SGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSG
VLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSC
RPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERP
PHTGPGLTLFPDPRGPRAMEGPLGVR

Sequence length

326

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Stimulate	37542274	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Stimulate	36788088	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	33147937	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	37542274	★★★★★ ★☆☆☆☆ Found in Text Mining only

PVRIG (PVR related immunoglobulin domain containing)