Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79031
Gene name	Phosducin like 3
Gene symbol	PDCL3
Synonyms (NCBI Gene)	HTPHLPPHLP2APHLP3VIAFVIAF1
Chromosome	2
Chromosome location	2q11.2
Summary	This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been show

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030318	hsa-miR-26b-5p	Microarray	19088304
MIRT052304	hsa-let-7b-5p	CLASH	23622248
MIRT045741	hsa-miR-125a-5p	CLASH	23622248
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23313552
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT622884	hsa-miR-4252	HITS-CLIP	23313552
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT622880	hsa-miR-7703	HITS-CLIP	23313552
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT637852	hsa-miR-3160-3p	HITS-CLIP	23824327
MIRT637851	hsa-miR-558	HITS-CLIP	23824327
MIRT637850	hsa-miR-4487	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	PAR-CLIP	26701625
MIRT637852	hsa-miR-3160-3p	PAR-CLIP	26701625
MIRT637850	hsa-miR-4487	PAR-CLIP	26701625
MIRT637853	hsa-miR-5186	PAR-CLIP	26701625
MIRT622879	hsa-miR-550b-2-5p	PAR-CLIP	26701625
MIRT637851	hsa-miR-558	PAR-CLIP	26701625
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23313552
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT622884	hsa-miR-4252	HITS-CLIP	23313552
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT622880	hsa-miR-7703	HITS-CLIP	23313552
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23313552
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT637853	hsa-miR-5186	HITS-CLIP	23824327
MIRT637852	hsa-miR-3160-3p	HITS-CLIP	23824327
MIRT637851	hsa-miR-558	HITS-CLIP	23824327
MIRT637850	hsa-miR-4487	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT635776	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT635775	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT635774	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT635773	hsa-miR-4459	HITS-CLIP	23824327
MIRT635772	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT635771	hsa-miR-4267	HITS-CLIP	23824327
MIRT635770	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT635769	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT635768	hsa-miR-4268	HITS-CLIP	23824327
MIRT635766	hsa-miR-7977	HITS-CLIP	23824327
MIRT635767	hsa-miR-3686	HITS-CLIP	23824327
MIRT635765	hsa-miR-665	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622888	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT296909	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT622887	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT622886	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT296911	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT622885	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT622884	hsa-miR-4252	HITS-CLIP	23824327
MIRT622883	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT622882	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT622881	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT622880	hsa-miR-7703	HITS-CLIP	23824327
MIRT622879	hsa-miR-550b-2-5p	HITS-CLIP	23824327

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	IMP	26059764
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	23792958
GO:0005515	Function	Protein binding	IPI	15371430, 17429077, 19012568, 26059764, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15371430, 26059764
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	26059764
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IMP	26059764
GO:0006915	Process	Apoptotic process	IEA
GO:0010628	Process	Positive regulation of gene expression	IBA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	26059764
GO:0030036	Process	Actin cytoskeleton organization	IMP	17429077
GO:0032991	Component	Protein-containing complex	IEA
GO:0043184	Function	Vascular endothelial growth factor receptor 2 binding	IBA
GO:0043184	Function	Vascular endothelial growth factor receptor 2 binding	IEA
GO:0044183	Function	Protein folding chaperone	IBA
GO:0044183	Function	Protein folding chaperone	IMP	26059764
GO:0044183	Function	Protein folding chaperone	IPI	23792958
GO:0045766	Process	Positive regulation of angiogenesis	IMP	23792958
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050730	Process	Regulation of peptidyl-tyrosine phosphorylation	IMP	23792958
GO:0050821	Process	Protein stabilization	IMP	26059764
GO:0097356	Component	Perinucleolar compartment	IDA	26059764
GO:1903333	Process	Negative regulation of protein folding	IMP	17429077
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IMP	23792958

MIM	HGNC	e!Ensembl
611678	28860	ENSG00000115539

Q9H2J4

Protein name

Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)

Protein function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (

PDB

7NVM , 8I1U , 8I6J , 8I9Q , 8I9U , 8IB8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02114	Phosducin	7 → 235	Phosducin	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430). {ECO:0000269|PubMed:15371430, ECO:00

Sequence

MQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSVVKTYEDMTLEELEDHE
DEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLY
KQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIG
PLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIEDVLLSSVRRSVLMKRDSDSEGD

Sequence length

239

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MEGACYSTIS MICROCOLON INTESTINAL HYPOPERISTALSIS SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEGACYSTIS-MICROCOLON-INTESTINAL HYPOPERISTALSIS SYNDROME	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Glioma	Associate	37006287	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	37006287	★★★★★ ★☆☆☆☆ Found in Text Mining only

PDCL3 (phosducin like 3)