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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7903
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Gene name
Gene Name - the full gene name approved by the HGNC.
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ST8SIA4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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PST, PST1, SIAT8-D, SIAT8D, ST8SIA-IV, ST8SiaIV |
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Chromosome
Chromosome number
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5 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5q21.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a |
| UniProt ID |
Q92187
|
| Protein name |
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV) |
| Protein function |
Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:112790 |
| PDB |
5Y22
,
5Y3U
,
6AHZ
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
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PF00777
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Glyco_transf_29 |
94 → 353 |
Glycosyltransferase family 29 (sialyltransferase) |
Family |
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| Tissue specificity |
TISSUE SPECIFICITY: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus (PubMed:7624364). Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes (PubMed:76243 |
| Sequence |
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| Sequence length |
359 |
| Interactions |
View interactions
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