Gene Gene information from NCBI Gene database.
Entrez ID 7903
Gene name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene symbol ST8SIA4
Synonyms (NCBI Gene)
PSTPST1SIAT8-DSIAT8DST8SIA-IVST8SiaIV
Chromosome 5
Chromosome location 5q21.1
Summary The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a
miRNA miRNA information provided by mirtarbase database.
449
miRTarBase ID miRNA Experiments Reference
MIRT017872 hsa-miR-335-5p Microarray 18185580
MIRT540861 hsa-miR-8485 HITS-CLIP 21572407
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0001574 Process Ganglioside biosynthetic process IDA 10766765
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 9774483, 10766765
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602547 10871 ENSG00000113532
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92187
Protein name CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)
Protein function Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:112790
PDB 5Y22 , 5Y3U , 6AHZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 94 353 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus (PubMed:7624364). Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes (PubMed:76243
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sialic acid metabolism
NCAM1 interactions