Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7903
Gene name Gene Name - the full gene name approved by the HGNC.
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ST8SIA4
Synonyms (NCBI Gene) Gene synonyms aliases
PST, PST1, SIAT8-D, SIAT8D, ST8SIA-IV, ST8SiaIV
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017872 hsa-miR-335-5p Microarray 18185580
MIRT540861 hsa-miR-8485 HITS-CLIP 21572407
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
MIRT540861 hsa-miR-8485 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0001574 Process Ganglioside biosynthetic process IDA 10766765
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA 21873635
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 10766765
GO:0006464 Process Cellular protein modification process TAS 7854457
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602547 10871 ENSG00000113532
Protein
UniProt ID Q92187
Protein name CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)
Protein function Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:112790
PDB 5Y22 , 5Y3U , 6AHZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 94 353 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus (PubMed:7624364). Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes (PubMed:76243
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sialic acid metabolism
NCAM1 interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Coronary Heart Disease Coronary Heart Disease GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Biliary Cholangitis Biliary Cholangitis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36853323
Asthma Stimulate 25997986
Breast Neoplasms Associate 28032858, 34278507
Carcinogenesis Associate 30105850
Carcinoma Hepatocellular Associate 12495467
Leukodystrophy Metachromatic Associate 19725832
Lupus Erythematosus Systemic Associate 23740754
Multiple Sclerosis Associate 18322311
Neoplasm Metastasis Associate 30105850
Neoplasm Metastasis Stimulate 37227919