Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79016
Gene name Gene Name - the full gene name approved by the HGNC.
DET1 and DDB1 associated 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DDA1
Synonyms (NCBI Gene) Gene synonyms aliases
C19orf58, PCIA1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT613168 hsa-miR-140-3p HITS-CLIP 23824327
MIRT613167 hsa-miR-2682-5p HITS-CLIP 23824327
MIRT613166 hsa-miR-34b-5p HITS-CLIP 23824327
MIRT613165 hsa-miR-449c-5p HITS-CLIP 23824327
MIRT613164 hsa-miR-4514 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IMP 31686031
GO:0005515 Function Protein binding IPI 16949367, 20562859, 25416956, 30564455, 32296183, 32814053, 35271311
GO:0005654 Component Nucleoplasm TAS
GO:0016567 Process Protein ubiquitination IEA
GO:0032434 Process Regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein
UniProt ID Q9BW61
Protein name DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)
Protein function Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28302793, PubMed:284373
PDB 6DSZ , 6PAI , 6Q0R , 6Q0V , 6Q0W , 6SJ7 , 6UD7 , 6UE5 , 8G46 , 8QH5 , 8ROX , 8ROY , 8TL6 , 9BZ0 , 9DHD , 9FD2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10172 DDA1 3 65 Det1 complexing ubiquitin ligase Family
Sequence
Sequence length 102
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 32444848
Leukemia Myeloid Acute Associate 31002141
Neoplasm Metastasis Associate 32444848
Ovarian Neoplasms Associate 28387912
Prostatic Hyperplasia Associate 36974949
Prostatic Neoplasms Associate 36974949