CUEDC2 (CUE domain containing 2)

Gene

• Entrez ID: 79004
• Gene name: CUE domain containing 2
• Gene symbol: CUEDC2
• Synonyms (NCBI Gene): C10orf66, bA18I14.5
• Chromosome: 10
• Chromosome location: 10q24.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045300	hsa-miR-186-5p	CLASH	23622248
MIRT043568	hsa-miR-331-3p	CLASH	23622248
MIRT043183	hsa-miR-324-5p	CLASH	23622248
MIRT039666	hsa-miR-615-3p	CLASH	23622248
MIRT916366	hsa-miR-141	CLIP-seq
MIRT916367	hsa-miR-154	CLIP-seq
MIRT916368	hsa-miR-200a	CLIP-seq
MIRT916369	hsa-miR-3123	CLIP-seq
MIRT916370	hsa-miR-3154	CLIP-seq
MIRT916371	hsa-miR-3179	CLIP-seq
MIRT916372	hsa-miR-3925-5p	CLIP-seq
MIRT916373	hsa-miR-4278	CLIP-seq
MIRT916374	hsa-miR-4433	CLIP-seq
MIRT916375	hsa-miR-4653-3p	CLIP-seq
MIRT916376	hsa-miR-4716-3p	CLIP-seq
MIRT916377	hsa-miR-4802-5p	CLIP-seq
MIRT916366	hsa-miR-141	CLIP-seq
MIRT916368	hsa-miR-200a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17347654, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0010936	Process	Negative regulation of macrophage cytokine production	IEA
GO:0010936	Process	Negative regulation of macrophage cytokine production	IMP	24882011
GO:0031965	Component	Nuclear membrane	IDA
GO:0043130	Function	Ubiquitin binding	IEA
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IEA
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IMP	24882011

Other IDs

• MIM: 614142
• HGNC: 28352
• e!Ensembl: ENSG00000107874

Protein

• UniProt ID: Q9H467
• Protein name: CUE domain-containing protein 2
• Protein function: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechani
• Tissue specificity: TISSUE SPECIFICITY: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors
• Sequence:

  MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEM
  MEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEML
  KEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQ
  MLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEA
  PKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

• Sequence length: 287