OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2)

Gene

• Entrez ID: 78990
• Gene name: OTU deubiquitinase, ubiquitin aldehyde binding 2
• Gene symbol: OTUB2
• Synonyms (NCBI Gene): C14orf137, OTB2, OTU2
• Chromosome: 14
• Chromosome location: 14q32.12
• Summary: This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016886	hsa-miR-335-5p	Microarray	18185580
MIRT024538	hsa-miR-215-5p	Microarray	19074876
MIRT026192	hsa-miR-192-5p	Microarray	19074876
MIRT045773	hsa-miR-125a-5p	CLASH	23622248
MIRT638483	hsa-miR-1264	HITS-CLIP	19536157
MIRT638481	hsa-miR-4279	HITS-CLIP	19536157
MIRT638482	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT638483	hsa-miR-1264	HITS-CLIP	23824327
MIRT638481	hsa-miR-4279	HITS-CLIP	23824327
MIRT638482	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT638483	hsa-miR-1264	HITS-CLIP	23824327
MIRT638481	hsa-miR-4279	HITS-CLIP	23824327
MIRT638482	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT495373	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT535559	hsa-miR-3680-5p	PAR-CLIP	22012620
MIRT535558	hsa-miR-3943	PAR-CLIP	22012620
MIRT535557	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT535556	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT535555	hsa-miR-4682	PAR-CLIP	22012620
MIRT535554	hsa-miR-4424	PAR-CLIP	22012620
MIRT535553	hsa-miR-4313	PAR-CLIP	22012620
MIRT535552	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT535551	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT535550	hsa-miR-4420	PAR-CLIP	22012620
MIRT495373	hsa-miR-6856-3p	PAR-CLIP	23708386
MIRT495372	hsa-miR-4773	PAR-CLIP	23708386
MIRT495370	hsa-miR-6769a-3p	PAR-CLIP	23708386
MIRT495371	hsa-miR-3186-5p	PAR-CLIP	23708386
MIRT495369	hsa-miR-5687	PAR-CLIP	23708386
MIRT638483	hsa-miR-1264	HITS-CLIP	19536157
MIRT638481	hsa-miR-4279	HITS-CLIP	19536157
MIRT638482	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT638483	hsa-miR-1264	HITS-CLIP	23824327
MIRT638481	hsa-miR-4279	HITS-CLIP	23824327
MIRT638482	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT638483	hsa-miR-1264	HITS-CLIP	23824327
MIRT638481	hsa-miR-4279	HITS-CLIP	23824327
MIRT638482	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT495373	hsa-miR-6856-3p	PAR-CLIP	22012620
MIRT535559	hsa-miR-3680-5p	PAR-CLIP	22012620
MIRT535558	hsa-miR-3943	PAR-CLIP	22012620
MIRT535557	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT535556	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT535555	hsa-miR-4682	PAR-CLIP	22012620
MIRT535554	hsa-miR-4424	PAR-CLIP	22012620
MIRT535553	hsa-miR-4313	PAR-CLIP	22012620
MIRT535552	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT535551	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT535550	hsa-miR-4420	PAR-CLIP	22012620
MIRT495373	hsa-miR-6856-3p	PAR-CLIP	23708386
MIRT495372	hsa-miR-4773	PAR-CLIP	23708386
MIRT495370	hsa-miR-6769a-3p	PAR-CLIP	23708386
MIRT495371	hsa-miR-3186-5p	PAR-CLIP	23708386
MIRT495369	hsa-miR-5687	PAR-CLIP	23708386
MIRT755719	hsa-miR-455-3p	Luciferase reporter assay, Western blotting, qRT-PCR	38819228
MIRT1207288	hsa-miR-103a	CLIP-seq
MIRT1207289	hsa-miR-107	CLIP-seq
MIRT1207290	hsa-miR-1224-3p	CLIP-seq
MIRT1207291	hsa-miR-1245b-5p	CLIP-seq
MIRT1207292	hsa-miR-125a-3p	CLIP-seq
MIRT1207293	hsa-miR-1266	CLIP-seq
MIRT1207294	hsa-miR-129-5p	CLIP-seq
MIRT1207295	hsa-miR-1321	CLIP-seq
MIRT1207296	hsa-miR-140-5p	CLIP-seq
MIRT1207297	hsa-miR-145	CLIP-seq
MIRT1207298	hsa-miR-15a	CLIP-seq
MIRT1207299	hsa-miR-15b	CLIP-seq
MIRT1207300	hsa-miR-16	CLIP-seq
MIRT1207301	hsa-miR-1915	CLIP-seq
MIRT1207302	hsa-miR-195	CLIP-seq
MIRT1207303	hsa-miR-198	CLIP-seq
MIRT1207304	hsa-miR-214	CLIP-seq
MIRT1207305	hsa-miR-24	CLIP-seq
MIRT1207306	hsa-miR-298	CLIP-seq
MIRT1207307	hsa-miR-29a	CLIP-seq
MIRT1207308	hsa-miR-29b	CLIP-seq
MIRT1207309	hsa-miR-29c	CLIP-seq
MIRT1207310	hsa-miR-3065-3p	CLIP-seq
MIRT1207311	hsa-miR-3142	CLIP-seq
MIRT1207312	hsa-miR-3158-5p	CLIP-seq
MIRT1207313	hsa-miR-3159	CLIP-seq
MIRT1207314	hsa-miR-3187-3p	CLIP-seq
MIRT1207315	hsa-miR-3192	CLIP-seq
MIRT1207316	hsa-miR-3202	CLIP-seq
MIRT1207317	hsa-miR-342-5p	CLIP-seq
MIRT1207318	hsa-miR-3616-3p	CLIP-seq
MIRT1207319	hsa-miR-3616-5p	CLIP-seq
MIRT1207320	hsa-miR-3619-5p	CLIP-seq
MIRT1207321	hsa-miR-3647-5p	CLIP-seq
MIRT1207322	hsa-miR-3665	CLIP-seq
MIRT1207323	hsa-miR-3681	CLIP-seq
MIRT1207324	hsa-miR-3692	CLIP-seq
MIRT1207325	hsa-miR-3918	CLIP-seq
MIRT1207326	hsa-miR-3937	CLIP-seq
MIRT1207327	hsa-miR-424	CLIP-seq
MIRT1207328	hsa-miR-4260	CLIP-seq
MIRT1207329	hsa-miR-4267	CLIP-seq
MIRT1207330	hsa-miR-4270	CLIP-seq
MIRT1207331	hsa-miR-4283	CLIP-seq
MIRT1207332	hsa-miR-4291	CLIP-seq
MIRT1207333	hsa-miR-4314	CLIP-seq
MIRT1207334	hsa-miR-4423-5p	CLIP-seq
MIRT1207335	hsa-miR-4435	CLIP-seq
MIRT1207336	hsa-miR-4436b-3p	CLIP-seq
MIRT1207337	hsa-miR-4437	CLIP-seq
MIRT1207338	hsa-miR-4441	CLIP-seq
MIRT1207339	hsa-miR-4450	CLIP-seq
MIRT1207340	hsa-miR-4466	CLIP-seq
MIRT1207341	hsa-miR-4489	CLIP-seq
MIRT1207342	hsa-miR-4493	CLIP-seq
MIRT1207343	hsa-miR-450b-5p	CLIP-seq
MIRT1207344	hsa-miR-4512	CLIP-seq
MIRT1207345	hsa-miR-4518	CLIP-seq
MIRT1207346	hsa-miR-4533	CLIP-seq
MIRT1207347	hsa-miR-4646-5p	CLIP-seq
MIRT1207348	hsa-miR-4651	CLIP-seq
MIRT1207349	hsa-miR-4659a-5p	CLIP-seq
MIRT1207350	hsa-miR-4659b-5p	CLIP-seq
MIRT1207351	hsa-miR-4664-5p	CLIP-seq
MIRT1207352	hsa-miR-4667-5p	CLIP-seq
MIRT1207353	hsa-miR-4668-3p	CLIP-seq
MIRT1207354	hsa-miR-4685-5p	CLIP-seq
MIRT1207355	hsa-miR-4700-5p	CLIP-seq
MIRT1207356	hsa-miR-4701-5p	CLIP-seq
MIRT1207357	hsa-miR-4712-5p	CLIP-seq
MIRT1207358	hsa-miR-4719	CLIP-seq
MIRT1207359	hsa-miR-4726-3p	CLIP-seq
MIRT1207360	hsa-miR-4731-5p	CLIP-seq
MIRT1207361	hsa-miR-4736	CLIP-seq
MIRT1207362	hsa-miR-4739	CLIP-seq
MIRT1207363	hsa-miR-4743	CLIP-seq
MIRT1207364	hsa-miR-4756-5p	CLIP-seq
MIRT1207365	hsa-miR-4771	CLIP-seq
MIRT1207366	hsa-miR-4776-3p	CLIP-seq
MIRT1207367	hsa-miR-4785	CLIP-seq
MIRT1207368	hsa-miR-4787-5p	CLIP-seq
MIRT1207369	hsa-miR-4795-5p	CLIP-seq
MIRT1207370	hsa-miR-497	CLIP-seq
MIRT1207371	hsa-miR-507	CLIP-seq
MIRT1207372	hsa-miR-508-5p	CLIP-seq
MIRT1207373	hsa-miR-513b	CLIP-seq
MIRT1207374	hsa-miR-518a-5p	CLIP-seq
MIRT1207375	hsa-miR-520a-5p	CLIP-seq
MIRT1207376	hsa-miR-525-5p	CLIP-seq
MIRT1207377	hsa-miR-527	CLIP-seq
MIRT1207378	hsa-miR-548c-3p	CLIP-seq
MIRT1207379	hsa-miR-548s	CLIP-seq
MIRT1207380	hsa-miR-557	CLIP-seq
MIRT1207381	hsa-miR-573	CLIP-seq
MIRT1207382	hsa-miR-588	CLIP-seq
MIRT1207383	hsa-miR-605	CLIP-seq
MIRT1207384	hsa-miR-608	CLIP-seq
MIRT1207385	hsa-miR-658	CLIP-seq
MIRT1207386	hsa-miR-675	CLIP-seq
MIRT1207387	hsa-miR-761	CLIP-seq
MIRT1207388	hsa-miR-766	CLIP-seq
MIRT1207389	hsa-miR-770-5p	CLIP-seq
MIRT1207390	hsa-miR-922	CLIP-seq
MIRT1551980	hsa-miR-3680	CLIP-seq
MIRT2059585	hsa-let-7a	CLIP-seq
MIRT2059586	hsa-let-7b	CLIP-seq
MIRT2059587	hsa-let-7c	CLIP-seq
MIRT2059588	hsa-let-7d	CLIP-seq
MIRT2059589	hsa-let-7e	CLIP-seq
MIRT2059590	hsa-let-7f	CLIP-seq
MIRT2059591	hsa-let-7g	CLIP-seq
MIRT2059592	hsa-let-7i	CLIP-seq
MIRT2059593	hsa-miR-125b	CLIP-seq
MIRT2059594	hsa-miR-129-3p	CLIP-seq
MIRT2059595	hsa-miR-134	CLIP-seq
MIRT1207301	hsa-miR-1915	CLIP-seq
MIRT2059596	hsa-miR-1976	CLIP-seq
MIRT1207304	hsa-miR-214	CLIP-seq
MIRT2059597	hsa-miR-3117-5p	CLIP-seq
MIRT2059598	hsa-miR-3118	CLIP-seq
MIRT1207320	hsa-miR-3619-5p	CLIP-seq
MIRT2059599	hsa-miR-370	CLIP-seq
MIRT2059600	hsa-miR-3927	CLIP-seq
MIRT1207326	hsa-miR-3937	CLIP-seq
MIRT2059601	hsa-miR-4319	CLIP-seq
MIRT2059602	hsa-miR-4324	CLIP-seq
MIRT2059603	hsa-miR-4451	CLIP-seq
MIRT2059604	hsa-miR-4458	CLIP-seq
MIRT2059605	hsa-miR-4480	CLIP-seq
MIRT2059606	hsa-miR-4500	CLIP-seq
MIRT755719	hsa-miR-455-3p	CLIP-seq
MIRT2059607	hsa-miR-4652-3p	CLIP-seq
MIRT2059608	hsa-miR-4687-5p	CLIP-seq
MIRT1207359	hsa-miR-4726-3p	CLIP-seq
MIRT1207363	hsa-miR-4743	CLIP-seq
MIRT2059609	hsa-miR-4747-5p	CLIP-seq
MIRT2059610	hsa-miR-4761-5p	CLIP-seq
MIRT2059611	hsa-miR-4786-3p	CLIP-seq
MIRT2059612	hsa-miR-483-3p	CLIP-seq
MIRT2059613	hsa-miR-671-5p	CLIP-seq
MIRT1207387	hsa-miR-761	CLIP-seq
MIRT2059614	hsa-miR-98	CLIP-seq
MIRT1207292	hsa-miR-125a-3p	CLIP-seq
MIRT2288025	hsa-miR-1276	CLIP-seq
MIRT2059595	hsa-miR-134	CLIP-seq
MIRT1207297	hsa-miR-145	CLIP-seq
MIRT2288026	hsa-miR-1913	CLIP-seq
MIRT2059596	hsa-miR-1976	CLIP-seq
MIRT1207303	hsa-miR-198	CLIP-seq
MIRT2288027	hsa-miR-2278	CLIP-seq
MIRT1207306	hsa-miR-298	CLIP-seq
MIRT2059597	hsa-miR-3117-5p	CLIP-seq
MIRT2059598	hsa-miR-3118	CLIP-seq
MIRT2288028	hsa-miR-324-3p	CLIP-seq
MIRT1207318	hsa-miR-3616-3p	CLIP-seq
MIRT1207322	hsa-miR-3665	CLIP-seq
MIRT2059599	hsa-miR-370	CLIP-seq
MIRT2288029	hsa-miR-4261	CLIP-seq
MIRT2288030	hsa-miR-4311	CLIP-seq
MIRT1207335	hsa-miR-4435	CLIP-seq
MIRT1207336	hsa-miR-4436b-3p	CLIP-seq
MIRT2288031	hsa-miR-4468	CLIP-seq
MIRT755719	hsa-miR-455-3p	CLIP-seq
MIRT2288032	hsa-miR-4648	CLIP-seq
MIRT2288033	hsa-miR-4713-3p	CLIP-seq
MIRT1207361	hsa-miR-4736	CLIP-seq
MIRT2059609	hsa-miR-4747-5p	CLIP-seq
MIRT2059611	hsa-miR-4786-3p	CLIP-seq
MIRT1207369	hsa-miR-4795-5p	CLIP-seq
MIRT2059612	hsa-miR-483-3p	CLIP-seq
MIRT1207375	hsa-miR-520a-5p	CLIP-seq
MIRT1207376	hsa-miR-525-5p	CLIP-seq
MIRT2288034	hsa-miR-583	CLIP-seq
MIRT2059613	hsa-miR-671-5p	CLIP-seq
MIRT2391986	hsa-miR-1184	CLIP-seq
MIRT2391987	hsa-miR-1205	CLIP-seq
MIRT1207301	hsa-miR-1915	CLIP-seq
MIRT2059596	hsa-miR-1976	CLIP-seq
MIRT2391988	hsa-miR-2115	CLIP-seq
MIRT1207304	hsa-miR-214	CLIP-seq
MIRT2391989	hsa-miR-2355-5p	CLIP-seq
MIRT2391990	hsa-miR-296-5p	CLIP-seq
MIRT2059597	hsa-miR-3117-5p	CLIP-seq
MIRT1207312	hsa-miR-3158-5p	CLIP-seq
MIRT2391991	hsa-miR-323b-5p	CLIP-seq
MIRT1207320	hsa-miR-3619-5p	CLIP-seq
MIRT1207324	hsa-miR-3692	CLIP-seq
MIRT2059599	hsa-miR-370	CLIP-seq
MIRT1207326	hsa-miR-3937	CLIP-seq
MIRT2391992	hsa-miR-3944-5p	CLIP-seq
MIRT1207332	hsa-miR-4291	CLIP-seq
MIRT2059605	hsa-miR-4480	CLIP-seq
MIRT1207359	hsa-miR-4726-3p	CLIP-seq
MIRT2059609	hsa-miR-4747-5p	CLIP-seq
MIRT1207365	hsa-miR-4771	CLIP-seq
MIRT2059611	hsa-miR-4786-3p	CLIP-seq
MIRT2059612	hsa-miR-483-3p	CLIP-seq
MIRT2391993	hsa-miR-516a-3p	CLIP-seq
MIRT2059613	hsa-miR-671-5p	CLIP-seq
MIRT1207387	hsa-miR-761	CLIP-seq
MIRT1207390	hsa-miR-922	CLIP-seq
MIRT2455753	hsa-miR-1228	CLIP-seq
MIRT2455754	hsa-miR-1324	CLIP-seq
MIRT2455755	hsa-miR-1343	CLIP-seq
MIRT2455756	hsa-miR-3064-3p	CLIP-seq
MIRT2455757	hsa-miR-4281	CLIP-seq
MIRT2455758	hsa-miR-4722-3p	CLIP-seq
MIRT2455759	hsa-miR-4763-5p	CLIP-seq
MIRT2391993	hsa-miR-516a-3p	CLIP-seq
MIRT2455760	hsa-miR-596	CLIP-seq
MIRT2455754	hsa-miR-1324	CLIP-seq
MIRT2455755	hsa-miR-1343	CLIP-seq
MIRT2455757	hsa-miR-4281	CLIP-seq
MIRT2391993	hsa-miR-516a-3p	CLIP-seq
MIRT1207303	hsa-miR-198	CLIP-seq
MIRT2686917	hsa-miR-3663-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	18954305, 23827681
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IMP	15258613
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	IMP	15258613
GO:0016787	Function	Hydrolase activity	IEA
GO:0035871	Process	Protein K11-linked deubiquitination	IDA	23827681
GO:0043130	Function	Ubiquitin binding	IBA
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	18954305, 23827681
GO:0071108	Process	Protein K48-linked deubiquitination	IDA	18954305, 23827681
GO:0071108	Process	Protein K48-linked deubiquitination	IEA

Other IDs

• MIM: 608338
• HGNC: 20351
• e!Ensembl: ENSG00000089723

Protein

• UniProt ID: Q96DC9
• Protein name: Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)
• Protein function: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-l
• PDB: 1TFF, 4FJV, 5QIO, 5QIP, 5QIQ, 5QIR, 5QIS, 5QIT, 5QIU, 5QIV, 5QIW, 5QIX, 5QIY, 5QIZ, 8CMS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10275	Peptidase_C65	1 → 230	Peptidase C65 Otubain	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in brain. {ECO:0000269|PubMed:12704427}.
• Sequence:

  MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSY
  LESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLK
  VFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQI
  TALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH

• Sequence length: 234

Pathways

Reactome:

Ovarian tumor domain proteases