Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	7884
Gene name	Stem-loop histone mRNA binding protein
Gene symbol	SLBP
Synonyms (NCBI Gene)	HBP
Chromosome	4
Chromosome location	4p16.3
Summary	This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023573	hsa-miR-1-3p	Microarray	18668037
MIRT029110	hsa-miR-26b-5p	Microarray	19088304
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT661929	hsa-miR-4643	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT554244	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT554243	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT554242	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT554241	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT554240	hsa-miR-4733-5p	PAR-CLIP	21572407
MIRT554239	hsa-miR-3124-3p	PAR-CLIP	21572407
MIRT554238	hsa-miR-106a-3p	PAR-CLIP	21572407
MIRT554237	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT554236	hsa-miR-507	PAR-CLIP	21572407
MIRT554235	hsa-miR-557	PAR-CLIP	21572407
MIRT554234	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT661929	hsa-miR-4643	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT609764	hsa-miR-8485	HITS-CLIP	23824327
MIRT609763	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609762	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609761	hsa-miR-8064	HITS-CLIP	23824327
MIRT554244	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT554243	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT554242	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT554241	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT554240	hsa-miR-4733-5p	PAR-CLIP	21572407
MIRT554239	hsa-miR-3124-3p	PAR-CLIP	21572407
MIRT554238	hsa-miR-106a-3p	PAR-CLIP	21572407
MIRT554237	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT554236	hsa-miR-507	PAR-CLIP	21572407
MIRT554235	hsa-miR-557	PAR-CLIP	21572407
MIRT554234	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT1351553	hsa-miR-10a	CLIP-seq
MIRT1351554	hsa-miR-10b	CLIP-seq
MIRT1351555	hsa-miR-1246	CLIP-seq
MIRT1351556	hsa-miR-1269	CLIP-seq
MIRT1351557	hsa-miR-1269b	CLIP-seq
MIRT1351558	hsa-miR-1276	CLIP-seq
MIRT1351559	hsa-miR-1297	CLIP-seq
MIRT1351560	hsa-miR-136	CLIP-seq
MIRT1351561	hsa-miR-208a	CLIP-seq
MIRT1351562	hsa-miR-208b	CLIP-seq
MIRT1351563	hsa-miR-2116	CLIP-seq
MIRT1351564	hsa-miR-219-5p	CLIP-seq
MIRT1351565	hsa-miR-26a	CLIP-seq
MIRT1351566	hsa-miR-26b	CLIP-seq
MIRT1351567	hsa-miR-3120-3p	CLIP-seq
MIRT1351568	hsa-miR-3157-3p	CLIP-seq
MIRT1351569	hsa-miR-3194-5p	CLIP-seq
MIRT1351570	hsa-miR-3198	CLIP-seq
MIRT1351571	hsa-miR-3614-3p	CLIP-seq
MIRT1351572	hsa-miR-3662	CLIP-seq
MIRT1351573	hsa-miR-3667-5p	CLIP-seq
MIRT1351574	hsa-miR-3668	CLIP-seq
MIRT1351575	hsa-miR-3919	CLIP-seq
MIRT1351576	hsa-miR-3924	CLIP-seq
MIRT1351577	hsa-miR-410	CLIP-seq
MIRT1351578	hsa-miR-4254	CLIP-seq
MIRT1351579	hsa-miR-4263	CLIP-seq
MIRT1351580	hsa-miR-4297	CLIP-seq
MIRT1351581	hsa-miR-4308	CLIP-seq
MIRT1351582	hsa-miR-4309	CLIP-seq
MIRT1351583	hsa-miR-4311	CLIP-seq
MIRT1351584	hsa-miR-432	CLIP-seq
MIRT1351585	hsa-miR-4435	CLIP-seq
MIRT1351586	hsa-miR-4445	CLIP-seq
MIRT1351587	hsa-miR-4465	CLIP-seq
MIRT1351588	hsa-miR-4473	CLIP-seq
MIRT1351589	hsa-miR-4509	CLIP-seq
MIRT1351590	hsa-miR-4529-3p	CLIP-seq
MIRT1351591	hsa-miR-466	CLIP-seq
MIRT1351592	hsa-miR-4666-5p	CLIP-seq
MIRT1351593	hsa-miR-4677-5p	CLIP-seq
MIRT1351594	hsa-miR-4699-3p	CLIP-seq
MIRT1351595	hsa-miR-4729	CLIP-seq
MIRT1351596	hsa-miR-4733-3p	CLIP-seq
MIRT1351597	hsa-miR-4744	CLIP-seq
MIRT1351598	hsa-miR-4782-3p	CLIP-seq
MIRT1351599	hsa-miR-4789-3p	CLIP-seq
MIRT1351600	hsa-miR-4799-5p	CLIP-seq
MIRT1351601	hsa-miR-4802-3p	CLIP-seq
MIRT1351602	hsa-miR-490-5p	CLIP-seq
MIRT1351603	hsa-miR-496	CLIP-seq
MIRT1351604	hsa-miR-499-5p	CLIP-seq
MIRT1351605	hsa-miR-508-3p	CLIP-seq
MIRT1351606	hsa-miR-512-3p	CLIP-seq
MIRT1351607	hsa-miR-519a	CLIP-seq
MIRT1351608	hsa-miR-519b-3p	CLIP-seq
MIRT1351609	hsa-miR-519c-3p	CLIP-seq
MIRT1351610	hsa-miR-520f	CLIP-seq
MIRT1351611	hsa-miR-576-5p	CLIP-seq
MIRT1351612	hsa-miR-578	CLIP-seq
MIRT1351613	hsa-miR-583	CLIP-seq
MIRT1351614	hsa-miR-590-3p	CLIP-seq
MIRT1351615	hsa-miR-605	CLIP-seq
MIRT1351616	hsa-miR-618	CLIP-seq
MIRT1351617	hsa-miR-630	CLIP-seq
MIRT1351618	hsa-miR-720	CLIP-seq
MIRT1351619	hsa-miR-765	CLIP-seq
MIRT2104213	hsa-miR-132	CLIP-seq
MIRT2104214	hsa-miR-194	CLIP-seq
MIRT2104215	hsa-miR-212	CLIP-seq
MIRT1351567	hsa-miR-3120-3p	CLIP-seq
MIRT1351595	hsa-miR-4729	CLIP-seq
MIRT1351614	hsa-miR-590-3p	CLIP-seq
MIRT1351619	hsa-miR-765	CLIP-seq
MIRT1351556	hsa-miR-1269	CLIP-seq
MIRT1351557	hsa-miR-1269b	CLIP-seq
MIRT1351559	hsa-miR-1297	CLIP-seq
MIRT2104213	hsa-miR-132	CLIP-seq
MIRT1351560	hsa-miR-136	CLIP-seq
MIRT2104214	hsa-miR-194	CLIP-seq
MIRT1351561	hsa-miR-208a	CLIP-seq
MIRT1351562	hsa-miR-208b	CLIP-seq
MIRT2104215	hsa-miR-212	CLIP-seq
MIRT1351565	hsa-miR-26a	CLIP-seq
MIRT1351566	hsa-miR-26b	CLIP-seq
MIRT1351567	hsa-miR-3120-3p	CLIP-seq
MIRT2328383	hsa-miR-3622a-3p	CLIP-seq
MIRT2328384	hsa-miR-3622b-3p	CLIP-seq
MIRT1351573	hsa-miR-3667-5p	CLIP-seq
MIRT1351575	hsa-miR-3919	CLIP-seq
MIRT1351577	hsa-miR-410	CLIP-seq
MIRT2328385	hsa-miR-4291	CLIP-seq
MIRT2328386	hsa-miR-4310	CLIP-seq
MIRT1351584	hsa-miR-432	CLIP-seq
MIRT1351587	hsa-miR-4465	CLIP-seq
MIRT1351590	hsa-miR-4529-3p	CLIP-seq
MIRT2328387	hsa-miR-455-3p	CLIP-seq
MIRT1351591	hsa-miR-466	CLIP-seq
MIRT1351592	hsa-miR-4666-5p	CLIP-seq
MIRT1351594	hsa-miR-4699-3p	CLIP-seq
MIRT1351595	hsa-miR-4729	CLIP-seq
MIRT2328388	hsa-miR-4760-3p	CLIP-seq
MIRT1351599	hsa-miR-4789-3p	CLIP-seq
MIRT1351600	hsa-miR-4799-5p	CLIP-seq
MIRT1351601	hsa-miR-4802-3p	CLIP-seq
MIRT1351604	hsa-miR-499-5p	CLIP-seq
MIRT2328389	hsa-miR-556-5p	CLIP-seq
MIRT1351612	hsa-miR-578	CLIP-seq
MIRT1351614	hsa-miR-590-3p	CLIP-seq
MIRT2328390	hsa-miR-610	CLIP-seq
MIRT2328391	hsa-miR-7	CLIP-seq
MIRT1351618	hsa-miR-720	CLIP-seq
MIRT1351619	hsa-miR-765	CLIP-seq
MIRT2104213	hsa-miR-132	CLIP-seq
MIRT2104214	hsa-miR-194	CLIP-seq
MIRT2104215	hsa-miR-212	CLIP-seq
MIRT1351555	hsa-miR-1246	CLIP-seq
MIRT2104213	hsa-miR-132	CLIP-seq
MIRT2623083	hsa-miR-133a	CLIP-seq
MIRT2623084	hsa-miR-133b	CLIP-seq
MIRT2104215	hsa-miR-212	CLIP-seq
MIRT2623085	hsa-miR-3148	CLIP-seq
MIRT2623086	hsa-miR-3190	CLIP-seq
MIRT2328383	hsa-miR-3622a-3p	CLIP-seq
MIRT2328384	hsa-miR-3622b-3p	CLIP-seq
MIRT1351574	hsa-miR-3668	CLIP-seq
MIRT1351576	hsa-miR-3924	CLIP-seq
MIRT2623087	hsa-miR-4281	CLIP-seq
MIRT2623088	hsa-miR-4522	CLIP-seq
MIRT2328387	hsa-miR-455-3p	CLIP-seq
MIRT1351592	hsa-miR-4666-5p	CLIP-seq
MIRT2623089	hsa-miR-4699-5p	CLIP-seq
MIRT1351601	hsa-miR-4802-3p	CLIP-seq
MIRT1351602	hsa-miR-490-5p	CLIP-seq
MIRT2623090	hsa-miR-548aa	CLIP-seq
MIRT1351615	hsa-miR-605	CLIP-seq
MIRT1351555	hsa-miR-1246	CLIP-seq
MIRT2104213	hsa-miR-132	CLIP-seq
MIRT2623083	hsa-miR-133a	CLIP-seq
MIRT2623084	hsa-miR-133b	CLIP-seq
MIRT2104215	hsa-miR-212	CLIP-seq
MIRT2623085	hsa-miR-3148	CLIP-seq
MIRT2623086	hsa-miR-3190	CLIP-seq
MIRT2328383	hsa-miR-3622a-3p	CLIP-seq
MIRT2328384	hsa-miR-3622b-3p	CLIP-seq
MIRT2623087	hsa-miR-4281	CLIP-seq
MIRT2623088	hsa-miR-4522	CLIP-seq
MIRT2328387	hsa-miR-455-3p	CLIP-seq
MIRT1351592	hsa-miR-4666-5p	CLIP-seq
MIRT2623089	hsa-miR-4699-5p	CLIP-seq
MIRT1351601	hsa-miR-4802-3p	CLIP-seq
MIRT1351602	hsa-miR-490-5p	CLIP-seq
MIRT2623090	hsa-miR-548aa	CLIP-seq
MIRT1351615	hsa-miR-605	CLIP-seq

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Transcription factor	Regulation	Reference
UPF1	Unknown	25016523

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002191	Process	Cap-dependent translational initiation	IDA	18025107
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IDA	16912046
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15829567, 16086026, 18172165, 23286197, 23329046, 23804756
GO:0005634	Component	Nucleus	IDA	15829567
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15829567
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	23286197
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006398	Process	MRNA 3'-end processing by stem-loop binding and cleavage	IBA
GO:0006398	Process	MRNA 3'-end processing by stem-loop binding and cleavage	IEA
GO:0006398	Process	MRNA 3'-end processing by stem-loop binding and cleavage	ISS
GO:0042802	Function	Identical protein binding	IPI	23286197
GO:0051028	Process	MRNA transport	IBA
GO:0051028	Process	MRNA transport	IDA	19155325
GO:0062073	Component	Histone mRNA stem-loop binding complex	IPI	23286197
GO:0071204	Component	Histone pre-mRNA 3'end processing complex	IBA
GO:0071204	Component	Histone pre-mRNA 3'end processing complex	IEA
GO:0071204	Component	Histone pre-mRNA 3'end processing complex	ISS
GO:0071207	Function	Histone pre-mRNA stem-loop binding	IBA
GO:0071207	Function	Histone pre-mRNA stem-loop binding	IEA
GO:0071207	Function	Histone pre-mRNA stem-loop binding	ISS
GO:0071208	Function	Histone pre-mRNA DCP binding	ISS
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990904	Component	Ribonucleoprotein complex	TAS	10825184

MIM	HGNC	e!Ensembl
602422	10904	ENSG00000163950

Q14493

Protein name

Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)

Protein function

RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end proc

PDB

2KJM , 4L8R , 4QOZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15247	SLBP_RNA_bind	130 → 199	Histone RNA hairpin-binding protein RNA-binding domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9049306}.

Sequence

MACRPRSPPRHQSRCDGDASPPSPARWSLGRKRRADGRRWRPEDAEEAEHRGAERRPESF
TTPEGPKPRSRCSDWASAVEEDEMRTRVNKEMARYKRKLLINDFGRERKSSSGSSDSKES
MSTVPADFETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPKTPNKFKKYSR
RSWDQQIKLWKVALHFWDPPAEEGCDLQEIHPVDLESAESSSEPQTSSQDDFDVYSGTPT
KVRHMDSQVEDEFDLEACLTEPLRDFSAMS

Sequence length

270

Interactions

View interactions

	Reactome
			Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP (stem-loop histone mRNA binding protein)