Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7871
Gene name Gene Name - the full gene name approved by the HGNC.
Sarcolemma associated protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLMAP
Synonyms (NCBI Gene) Gene synonyms aliases
SLAP
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptos
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020271 hsa-miR-130b-3p Sequencing 20371350
MIRT031055 hsa-miR-21-5p Microarray 18591254
MIRT031211 hsa-miR-19b-3p Sequencing 20371350
MIRT031055 hsa-miR-21-5p HITS-CLIP 22473208
MIRT031055 hsa-miR-21-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23386615, 24255178, 24366813, 25416956, 30622739, 32707033, 35271311
GO:0005737 Component Cytoplasm IDA 29063833
GO:0005737 Component Cytoplasm IEA
GO:0005739 Component Mitochondrion IEA
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602701 16643 ENSG00000163681
Protein
UniProt ID Q14BN4
Protein name Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)
Protein function Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the i
PDB 6AKM , 6AR0 , 6AR2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00498 FHA 28 106 FHA domain Family
Sequence
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWF
DHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFG
VDVTENTRKVTHGC
IVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQ
MLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKEL
IALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEEL
RELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKI
EALQADNDFTNERLTALQVRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQKKLI
VEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVS
LLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEE
STKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDT
DIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELE
KLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELEN
QVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITD
ELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGLARASP
Sequence length 828
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Brugada Syndrome brugada syndrome N/A N/A ClinVar
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 31160357
Adie Syndrome Associate 24889065
Carcinoma Non Small Cell Lung Associate 31160357
Carcinoma Renal Cell Associate 30837581
Colorectal Neoplasms Associate 36623729
Diabetes Mellitus Associate 25880194
Diabetic Retinopathy Associate 25880194, 32587868
Ganglioglioma Associate 26810070
Lateral meningocele syndrome Associate 21412072
Leiomyosarcoma Associate 19901961, 28893210