Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7855
Gene name Gene Name - the full gene name approved by the HGNC.
Frizzled class receptor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FZD5
Synonyms (NCBI Gene) Gene synonyms aliases
C2orf31, HFZ5, MCOPCB11
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MCOPCB11
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.3
Summary Summary of gene provided in NCBI Entrez Gene.
Members of the `frizzled` gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030330 hsa-miR-26b-5p Microarray 19088304
MIRT030625 hsa-miR-24-3p Sequencing 20371350
MIRT045455 hsa-miR-149-5p CLASH 23622248
MIRT523606 hsa-miR-374b-5p HITS-CLIP 21572407
MIRT523605 hsa-miR-369-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000578 Process Embryonic axis specification IDA 12121999
GO:0001525 Process Angiogenesis IEA
GO:0001540 Function Amyloid-beta binding IPI 18234671
GO:0001540 Function Amyloid-beta binding TAS 24449494
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601723 4043 ENSG00000163251
Protein
UniProt ID Q13467
Protein name Frizzled-5 (Fz-5) (hFz5) (FzE5)
Protein function Receptor for Wnt proteins (PubMed:10097073, PubMed:20530549, PubMed:26908622, PubMed:9054360). Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity)
PDB 5URY , 5URZ , 6O39 , 6WW2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01392 Fz 33 141 Fz domain Domain
PF01534 Frizzled 226 537 Frizzled/Smoothened family membrane region Family
Sequence
Sequence length 585
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
RNF mutants show enhanced WNT signaling and proliferation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Microphthalmia With Coloboma microphthalmia/coloboma 11 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 30841855, 35328735
Arthritis Psoriatic Associate 20376066
Arthritis Rheumatoid Associate 10688908, 11315916
Barrett Esophagus Associate 30841855, 35328735
Breast Neoplasms Associate 25209439, 36001375
Carcinoma Embryonal Associate 19874621
Carcinoma Renal Cell Stimulate 15557753
Carcinoma Renal Cell Associate 25861751
Coloboma Associate 32737437, 33633439, 36695497
Colorectal Neoplasms Inhibit 37595345