RNF103 (ring finger protein 103)

Gene

• Entrez ID: 7844
• Gene name: Ring finger protein 103
• Gene symbol: RNF103
• Synonyms (NCBI Gene): HKF-1, KF-1, KF1, ZFP-103, ZFP103
• Chromosome: 2
• Chromosome location: 2p11.2
• Summary: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counter

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044458	hsa-miR-320a	CLASH	23622248
MIRT036187	hsa-miR-320b	CLASH	23622248
MIRT439765	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT439765	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT726738	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726739	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726737	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1309058	hsa-miR-1264	CLIP-seq
MIRT1309059	hsa-miR-431	CLIP-seq
MIRT1309060	hsa-miR-4457	CLIP-seq
MIRT1309061	hsa-miR-4731-3p	CLIP-seq
MIRT1309062	hsa-miR-4778-5p	CLIP-seq
MIRT1309063	hsa-miR-4801	CLIP-seq
MIRT1309064	hsa-miR-513a-3p	CLIP-seq
MIRT1309065	hsa-miR-640	CLIP-seq
MIRT1309066	hsa-miR-643	CLIP-seq
MIRT1309067	hsa-miR-885-5p	CLIP-seq
MIRT1309068	hsa-miR-3148	CLIP-seq
MIRT1309069	hsa-miR-3661	CLIP-seq
MIRT1309070	hsa-miR-4517	CLIP-seq
MIRT1309071	hsa-miR-492	CLIP-seq
MIRT1309072	hsa-miR-548c-3p	CLIP-seq
MIRT1309073	hsa-miR-619	CLIP-seq
MIRT1309074	hsa-miR-631	CLIP-seq
MIRT1309075	hsa-miR-875-3p	CLIP-seq
MIRT1309076	hsa-miR-142-5p	CLIP-seq
MIRT1309077	hsa-miR-21	CLIP-seq
MIRT1309078	hsa-miR-25	CLIP-seq
MIRT1309079	hsa-miR-32	CLIP-seq
MIRT1309080	hsa-miR-330-3p	CLIP-seq
MIRT1309081	hsa-miR-340	CLIP-seq
MIRT1309082	hsa-miR-363	CLIP-seq
MIRT1309083	hsa-miR-367	CLIP-seq
MIRT1309084	hsa-miR-4662a-3p	CLIP-seq
MIRT1309085	hsa-miR-4717-3p	CLIP-seq
MIRT1309086	hsa-miR-590-5p	CLIP-seq
MIRT1309087	hsa-miR-888	CLIP-seq
MIRT1309088	hsa-miR-92a	CLIP-seq
MIRT1309089	hsa-miR-92b	CLIP-seq
MIRT2316254	hsa-miR-1247	CLIP-seq
MIRT2316255	hsa-miR-323-3p	CLIP-seq
MIRT2316256	hsa-miR-342-3p	CLIP-seq
MIRT2316257	hsa-miR-376a	CLIP-seq
MIRT2316258	hsa-miR-376b	CLIP-seq
MIRT2316259	hsa-miR-4775	CLIP-seq
MIRT2393791	hsa-miR-4652-3p	CLIP-seq
MIRT2612453	hsa-miR-3143	CLIP-seq
MIRT1309084	hsa-miR-4662a-3p	CLIP-seq
MIRT2612454	hsa-miR-543	CLIP-seq
MIRT2612455	hsa-miR-548an	CLIP-seq
MIRT1309087	hsa-miR-888	CLIP-seq
MIRT2612453	hsa-miR-3143	CLIP-seq
MIRT1309084	hsa-miR-4662a-3p	CLIP-seq
MIRT2612454	hsa-miR-543	CLIP-seq
MIRT2612455	hsa-miR-548an	CLIP-seq
MIRT1309087	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA	21873635
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	10500182
GO:0005515	Function	Protein binding	IPI	18675248
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	18675248
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0007417	Process	Central nervous system development	TAS	9070305
GO:0016021	Component	Integral component of membrane	IEA
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IDA	10500182
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IBA	21873635
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IDA	18675248
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	TAS
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS

Other IDs

• MIM: 602507
• HGNC: 12859
• e!Ensembl: ENSG00000239305

Protein

• UniProt ID: O00237
• Protein name: E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103)
• Protein function: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13639	zf-RING_2	619 → 663	Ring finger domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the normal cerebellum but not in the cerebral cortex. {ECO:0000269|PubMed:9070305}.
• Sequence:

  MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYS
  GLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWL
  VQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQT
  STSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLF
  ANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYG
  NHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTL
  GTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALF
  LSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVES
  DWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSE
  SENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNT
  NEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCP
  VCRWPSYKKKQPYAQHQPLSNDVPS

• Sequence length: 685

Pathways

Reactome:

ER Quality Control Compartment (ERQC)

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504

Unknown
Disease term	Disease name	Evidence	References	Source
Neuroticism	Neuroticism			GWAS
Mental Depression	Mental Depression			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Heart Failure	Heart Failure			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Basal Cell	Associate	2654297
Epidermolysis Bullosa	Associate	3891876