Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7841
Gene name Gene Name - the full gene name approved by the HGNC.	Mannosyl-oligosaccharide glucosidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MOGS
Synonyms (NCBI Gene) Gene synonyms aliases	CDG2B, CWH41, DER7, GCS1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the e

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121909291	C>G,T	Pathogenic	Coding sequence variant, missense variant
rs121909292	A>G	Pathogenic	Coding sequence variant, missense variant
rs202094225	A>G	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs371747622	T>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs587777323	G>A	Pathogenic	Stop gained, coding sequence variant
rs753961807	G>C,T	Pathogenic	Intron variant, coding sequence variant, missense variant
rs757997140	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs764778419	G>C	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant, intron variant
rs777654978	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs863225089	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs1057520537	G>A	Pathogenic	Coding sequence variant, stop gained
rs1399649784	->G	Pathogenic	Frameshift variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022588	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT043996	hsa-miR-378a-5p	CLASH	23622248
MIRT042520	hsa-miR-423-3p	CLASH	23622248
MIRT039951	hsa-miR-615-3p	CLASH	23622248
MIRT037160	hsa-miR-877-3p	CLASH	23622248
MIRT1155153	hsa-miR-1273f	CLIP-seq
MIRT1155154	hsa-miR-143	CLIP-seq
MIRT1155155	hsa-miR-181a	CLIP-seq
MIRT1155156	hsa-miR-181b	CLIP-seq
MIRT1155157	hsa-miR-181c	CLIP-seq
MIRT1155158	hsa-miR-181d	CLIP-seq
MIRT1155159	hsa-miR-1915	CLIP-seq
MIRT1155160	hsa-miR-203	CLIP-seq
MIRT1155161	hsa-miR-2277-3p	CLIP-seq
MIRT1155162	hsa-miR-23a	CLIP-seq
MIRT1155163	hsa-miR-23b	CLIP-seq
MIRT1155164	hsa-miR-23c	CLIP-seq
MIRT1155165	hsa-miR-299-3p	CLIP-seq
MIRT1155166	hsa-miR-3120-3p	CLIP-seq
MIRT1155167	hsa-miR-3121-3p	CLIP-seq
MIRT1155168	hsa-miR-3622a-3p	CLIP-seq
MIRT1155169	hsa-miR-3622b-3p	CLIP-seq
MIRT1155170	hsa-miR-3915	CLIP-seq
MIRT1155171	hsa-miR-3928	CLIP-seq
MIRT1155172	hsa-miR-4262	CLIP-seq
MIRT1155173	hsa-miR-4320	CLIP-seq
MIRT1155174	hsa-miR-4324	CLIP-seq
MIRT1155175	hsa-miR-4428	CLIP-seq
MIRT1155176	hsa-miR-4452	CLIP-seq
MIRT1155177	hsa-miR-4464	CLIP-seq
MIRT1155178	hsa-miR-4476	CLIP-seq
MIRT1155179	hsa-miR-4491	CLIP-seq
MIRT1155180	hsa-miR-4522	CLIP-seq
MIRT1155181	hsa-miR-4648	CLIP-seq
MIRT1155182	hsa-miR-4654	CLIP-seq
MIRT1155183	hsa-miR-4657	CLIP-seq
MIRT1155184	hsa-miR-4685-5p	CLIP-seq
MIRT1155185	hsa-miR-4708-5p	CLIP-seq
MIRT1155186	hsa-miR-4748	CLIP-seq
MIRT1155187	hsa-miR-4769-5p	CLIP-seq
MIRT1155188	hsa-miR-4770	CLIP-seq
MIRT1155189	hsa-miR-4782-5p	CLIP-seq
MIRT1155153	hsa-miR-1273f	CLIP-seq
MIRT1155154	hsa-miR-143	CLIP-seq
MIRT1155160	hsa-miR-203	CLIP-seq
MIRT1155161	hsa-miR-2277-3p	CLIP-seq
MIRT1155166	hsa-miR-3120-3p	CLIP-seq
MIRT1155168	hsa-miR-3622a-3p	CLIP-seq
MIRT1155169	hsa-miR-3622b-3p	CLIP-seq
MIRT1155170	hsa-miR-3915	CLIP-seq
MIRT1155171	hsa-miR-3928	CLIP-seq
MIRT1155174	hsa-miR-4324	CLIP-seq
MIRT1155175	hsa-miR-4428	CLIP-seq
MIRT1155176	hsa-miR-4452	CLIP-seq
MIRT1155177	hsa-miR-4464	CLIP-seq
MIRT1155178	hsa-miR-4476	CLIP-seq
MIRT1155185	hsa-miR-4708-5p	CLIP-seq
MIRT1155186	hsa-miR-4748	CLIP-seq
MIRT1155188	hsa-miR-4770	CLIP-seq
MIRT2044393	hsa-miR-4774-5p	CLIP-seq
MIRT1155153	hsa-miR-1273f	CLIP-seq
MIRT1155154	hsa-miR-143	CLIP-seq
MIRT1155155	hsa-miR-181a	CLIP-seq
MIRT1155156	hsa-miR-181b	CLIP-seq
MIRT1155157	hsa-miR-181c	CLIP-seq
MIRT1155158	hsa-miR-181d	CLIP-seq
MIRT1155159	hsa-miR-1915	CLIP-seq
MIRT1155161	hsa-miR-2277-3p	CLIP-seq
MIRT1155162	hsa-miR-23a	CLIP-seq
MIRT1155163	hsa-miR-23b	CLIP-seq
MIRT1155164	hsa-miR-23c	CLIP-seq
MIRT1155165	hsa-miR-299-3p	CLIP-seq
MIRT1155166	hsa-miR-3120-3p	CLIP-seq
MIRT1155168	hsa-miR-3622a-3p	CLIP-seq
MIRT1155169	hsa-miR-3622b-3p	CLIP-seq
MIRT1155172	hsa-miR-4262	CLIP-seq
MIRT1155173	hsa-miR-4320	CLIP-seq
MIRT1155174	hsa-miR-4324	CLIP-seq
MIRT1155175	hsa-miR-4428	CLIP-seq
MIRT1155179	hsa-miR-4491	CLIP-seq
MIRT1155180	hsa-miR-4522	CLIP-seq
MIRT1155181	hsa-miR-4648	CLIP-seq
MIRT1155182	hsa-miR-4654	CLIP-seq
MIRT1155183	hsa-miR-4657	CLIP-seq
MIRT1155184	hsa-miR-4685-5p	CLIP-seq
MIRT1155185	hsa-miR-4708-5p	CLIP-seq
MIRT1155187	hsa-miR-4769-5p	CLIP-seq
MIRT1155188	hsa-miR-4770	CLIP-seq
MIRT1155189	hsa-miR-4782-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004573	Function	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA
GO:0004573	Function	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IEA
GO:0004573	Function	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	TAS
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	7635146
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006457	Process	Protein folding	TAS
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0006487	Process	Protein N-linked glycosylation	TAS	7635146
GO:0009311	Process	Oligosaccharide metabolic process	IEA
GO:0015926	Function	Glucosidase activity	IEA
GO:0015926	Function	Glucosidase activity	TAS	7635146
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7635146
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708

MIM	HGNC	e!Ensembl
601336	24862	ENSG00000115275

Protein

UniProt ID

Q13724

Protein name

Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I)

Protein function

In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16923	Glyco_hydro_63N	93 → 262	Glycosyl hydrolase family 63 N-terminal domain	Domain
PF03200	Glyco_hydro_63	352 → 835	Glycosyl hydrolase family 63 C-terminal domain	Domain

Sequence

MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGR
WVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLM
WAQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALRLTTEFVKRPGGQH
GGDWSWRVTVEPQDSGTSALPLVSLFFYVVTDGKEVLLPEVGAKGQLKFISGHTSELGDF
RFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGL
PGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQA
LESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGS
EQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNA
DGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPVAHMLEVGDPDDLAFLRKALPR
LHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPRASHPSVTERHLDL
RCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVFADFGNHTK
AVQLKPRPPQGLVRVVGRPQPQLQYVDALGYVSLFPLLLRLLDPTSSRLGPLLDILADSR
HLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALGALHHYGHLEGPHQARA
AKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLVLLAMAEDY

Sequence length

837

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum		Defective MOGS causes MOGS-CDG (CDG-2b) N-glycan trimming in the ER and Calnexin/Calreticulin cycle

MOGS (mannosyl-oligosaccharide glucosidase)