BTG2 (BTG anti-proliferation factor 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7832
Gene name Gene Name - the full gene name approved by the HGNC.
BTG anti-proliferation factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BTG2
Synonyms (NCBI Gene) Gene synonyms aliases
APRO1, PC3, TIS21
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PC3
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1965)
miRTarBase ID miRNA Experiments Reference
MIRT002416 hsa-miR-21-5p semi-qRT-PCR, GFP reporter assay, Western blot 19546886
MIRT002416 hsa-miR-21-5p semi-qRT-PCR, GFP reporter assay, Western blot 19546886
MIRT002416 hsa-miR-21-5p Luciferase reporter assay 19546886
MIRT002416 hsa-miR-21-5p Review 20026422
MIRT025795 hsa-miR-7-5p Sequencing 20371350
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
Transcription factor Regulation Reference
AR Repression 16281084
ESR1 Repression 19117054
FOXM1 Activation 19615363
NFKB1 Unknown 17363596
PHB2 Repression 19117054
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003714 Function Transcription corepressor activity IEA
GO:0005515 Function Protein binding IPI 9712883, 11136725, 18337750, 21172304, 25416956, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601597 1131 ENSG00000159388
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P78543
Protein name Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
Protein function Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNO
PDB 3DJU , 3E9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 9 → 122 BTG family Family
Sequence
Sequence length 158
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  RNA degradation   TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Multiple Sclerosis Multiple Sclerosis GWAS
Show/Hide Text Mining Associations (42)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32329853, 34580602, 35325730, 35730068
Adenocarcinoma of Lung Inhibit 37006240
Breast Neoplasms Associate 17234770, 20553615, 28922388, 34082648, 40496561
Breast Neoplasms Inhibit 19117054, 22493435
Carcinogenesis Associate 18840609, 35730068
Carcinogenesis Inhibit 25284287
Carcinoma Hepatocellular Associate 18840609, 26151427, 34217312
Carcinoma Non Small Cell Lung Associate 29656435, 31959200, 35388633
Carcinoma Renal Cell Associate 34337864, 36530957
Colonic Neoplasms Associate 28714374