Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7818
Gene name Gene Name - the full gene name approved by the HGNC.	Death associated protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DAP3
Synonyms (NCBI Gene) Gene synonyms aliases	DAP-3, MRP-S29, MRPS29, PRLTS7, S29mt, bMRP-10, mS29
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q22
Summary Summary of gene provided in NCBI Entrez Gene.	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031739	hsa-miR-16-5p	Proteomics	18668040
MIRT031739	hsa-miR-16-5p	CLASH	23622248
MIRT044320	hsa-miR-106b-5p	CLASH	23622248
MIRT043117	hsa-miR-324-5p	CLASH	23622248
MIRT040466	hsa-miR-615-3p	CLASH	23622248
MIRT036140	hsa-miR-1296-5p	CLASH	23622248
MIRT036140	hsa-miR-1296-5p	CLASH	23622248
MIRT923132	hsa-miR-1276	CLIP-seq
MIRT923133	hsa-miR-139-3p	CLIP-seq
MIRT923134	hsa-miR-3672	CLIP-seq
MIRT923135	hsa-miR-4294	CLIP-seq
MIRT923136	hsa-miR-431	CLIP-seq
MIRT923137	hsa-miR-4496	CLIP-seq
MIRT923138	hsa-miR-651	CLIP-seq
MIRT923139	hsa-miR-924	CLIP-seq
MIRT923140	hsa-miR-1281	CLIP-seq
MIRT923141	hsa-miR-24	CLIP-seq
MIRT923142	hsa-miR-3074-3p	CLIP-seq
MIRT923143	hsa-miR-3187-3p	CLIP-seq
MIRT923144	hsa-miR-361-5p	CLIP-seq
MIRT923145	hsa-miR-3919	CLIP-seq
MIRT923146	hsa-miR-4252	CLIP-seq
MIRT923147	hsa-miR-4284	CLIP-seq
MIRT923148	hsa-miR-4435	CLIP-seq
MIRT923149	hsa-miR-4438	CLIP-seq
MIRT923150	hsa-miR-4701-5p	CLIP-seq
MIRT923151	hsa-miR-4756-3p	CLIP-seq
MIRT923152	hsa-miR-4772-3p	CLIP-seq
MIRT923153	hsa-miR-5095	CLIP-seq
MIRT923154	hsa-miR-539	CLIP-seq
MIRT923155	hsa-miR-548s	CLIP-seq
MIRT923156	hsa-miR-588	CLIP-seq
MIRT1973505	hsa-miR-3177-5p	CLIP-seq
MIRT1973506	hsa-miR-122	CLIP-seq
MIRT1973507	hsa-miR-3135b	CLIP-seq
MIRT1973508	hsa-miR-3149	CLIP-seq
MIRT1973509	hsa-miR-3652	CLIP-seq
MIRT1973510	hsa-miR-4430	CLIP-seq
MIRT923149	hsa-miR-4438	CLIP-seq
MIRT1973511	hsa-miR-4715-3p	CLIP-seq
MIRT1973512	hsa-miR-4735-5p	CLIP-seq
MIRT1973513	hsa-miR-4775	CLIP-seq
MIRT923153	hsa-miR-5095	CLIP-seq
MIRT1973514	hsa-miR-590-3p	CLIP-seq
MIRT2209063	hsa-miR-1236	CLIP-seq
MIRT2209064	hsa-miR-1273d	CLIP-seq
MIRT2209065	hsa-miR-149	CLIP-seq
MIRT2209066	hsa-miR-155	CLIP-seq
MIRT2209067	hsa-miR-1910	CLIP-seq
MIRT2209068	hsa-miR-1914	CLIP-seq
MIRT2209069	hsa-miR-198	CLIP-seq
MIRT2209070	hsa-miR-2861	CLIP-seq
MIRT1973505	hsa-miR-3177-5p	CLIP-seq
MIRT2209071	hsa-miR-3665	CLIP-seq
MIRT2209072	hsa-miR-4268	CLIP-seq
MIRT2209073	hsa-miR-4418	CLIP-seq
MIRT2209074	hsa-miR-4421	CLIP-seq
MIRT2209075	hsa-miR-4512	CLIP-seq
MIRT2209076	hsa-miR-509-3-5p	CLIP-seq
MIRT2209077	hsa-miR-509-5p	CLIP-seq
MIRT2209078	hsa-miR-520a-5p	CLIP-seq
MIRT2209079	hsa-miR-525-5p	CLIP-seq
MIRT2209080	hsa-miR-617	CLIP-seq
MIRT2209081	hsa-miR-624	CLIP-seq
MIRT2209082	hsa-miR-657	CLIP-seq
MIRT2209083	hsa-miR-660	CLIP-seq
MIRT2386715	hsa-miR-1913	CLIP-seq
MIRT2386716	hsa-miR-3189-3p	CLIP-seq
MIRT2386717	hsa-miR-324-3p	CLIP-seq
MIRT2386718	hsa-miR-346	CLIP-seq
MIRT2386719	hsa-miR-4274	CLIP-seq
MIRT2386720	hsa-miR-4707-3p	CLIP-seq
MIRT2386721	hsa-miR-622	CLIP-seq
MIRT2386722	hsa-miR-635	CLIP-seq
MIRT1973508	hsa-miR-3149	CLIP-seq
MIRT2448035	hsa-miR-411	CLIP-seq
MIRT1973511	hsa-miR-4715-3p	CLIP-seq
MIRT1973512	hsa-miR-4735-5p	CLIP-seq
MIRT1973513	hsa-miR-4775	CLIP-seq
MIRT1973514	hsa-miR-590-3p	CLIP-seq
MIRT2512913	hsa-miR-106a	CLIP-seq
MIRT2512914	hsa-miR-106b	CLIP-seq
MIRT1973506	hsa-miR-122	CLIP-seq
MIRT923132	hsa-miR-1276	CLIP-seq
MIRT2512915	hsa-miR-1587	CLIP-seq
MIRT2512916	hsa-miR-17	CLIP-seq
MIRT2386715	hsa-miR-1913	CLIP-seq
MIRT2512917	hsa-miR-197	CLIP-seq
MIRT2512918	hsa-miR-20a	CLIP-seq
MIRT2512919	hsa-miR-20b	CLIP-seq
MIRT2512920	hsa-miR-2115	CLIP-seq
MIRT2512921	hsa-miR-302a	CLIP-seq
MIRT2512922	hsa-miR-302b	CLIP-seq
MIRT2512923	hsa-miR-302c	CLIP-seq
MIRT2512924	hsa-miR-302d	CLIP-seq
MIRT2512925	hsa-miR-302e	CLIP-seq
MIRT1973507	hsa-miR-3135b	CLIP-seq
MIRT2512926	hsa-miR-3140-5p	CLIP-seq
MIRT2512927	hsa-miR-3145-3p	CLIP-seq
MIRT1973508	hsa-miR-3149	CLIP-seq
MIRT2386716	hsa-miR-3189-3p	CLIP-seq
MIRT2386717	hsa-miR-324-3p	CLIP-seq
MIRT2386718	hsa-miR-346	CLIP-seq
MIRT1973509	hsa-miR-3652	CLIP-seq
MIRT2512928	hsa-miR-372	CLIP-seq
MIRT2512929	hsa-miR-373	CLIP-seq
MIRT2448035	hsa-miR-411	CLIP-seq
MIRT2386719	hsa-miR-4274	CLIP-seq
MIRT2512930	hsa-miR-4423-5p	CLIP-seq
MIRT1973510	hsa-miR-4430	CLIP-seq
MIRT923137	hsa-miR-4496	CLIP-seq
MIRT2512931	hsa-miR-4539	CLIP-seq
MIRT2512932	hsa-miR-4674	CLIP-seq
MIRT2512933	hsa-miR-4680-5p	CLIP-seq
MIRT2512934	hsa-miR-4684-3p	CLIP-seq
MIRT2386720	hsa-miR-4707-3p	CLIP-seq
MIRT1973511	hsa-miR-4715-3p	CLIP-seq
MIRT2512935	hsa-miR-4716-5p	CLIP-seq
MIRT1973512	hsa-miR-4735-5p	CLIP-seq
MIRT1973513	hsa-miR-4775	CLIP-seq
MIRT2512936	hsa-miR-5096	CLIP-seq
MIRT2512937	hsa-miR-512-3p	CLIP-seq
MIRT2512938	hsa-miR-518a-5p	CLIP-seq
MIRT2512939	hsa-miR-519d	CLIP-seq
MIRT2512940	hsa-miR-520a-3p	CLIP-seq
MIRT2512941	hsa-miR-520b	CLIP-seq
MIRT2512942	hsa-miR-520c-3p	CLIP-seq
MIRT2512943	hsa-miR-520d-3p	CLIP-seq
MIRT2512944	hsa-miR-520e	CLIP-seq
MIRT2512945	hsa-miR-520g	CLIP-seq
MIRT2512946	hsa-miR-520h	CLIP-seq
MIRT2512947	hsa-miR-527	CLIP-seq
MIRT1973514	hsa-miR-590-3p	CLIP-seq
MIRT2386721	hsa-miR-622	CLIP-seq
MIRT2386722	hsa-miR-635	CLIP-seq
MIRT923138	hsa-miR-651	CLIP-seq
MIRT2512948	hsa-miR-93	CLIP-seq
MIRT1973506	hsa-miR-122	CLIP-seq
MIRT2209064	hsa-miR-1273d	CLIP-seq
MIRT2209066	hsa-miR-155	CLIP-seq
MIRT2209067	hsa-miR-1910	CLIP-seq
MIRT2512917	hsa-miR-197	CLIP-seq
MIRT2209069	hsa-miR-198	CLIP-seq
MIRT1973507	hsa-miR-3135b	CLIP-seq
MIRT1973508	hsa-miR-3149	CLIP-seq
MIRT1973509	hsa-miR-3652	CLIP-seq
MIRT2209071	hsa-miR-3665	CLIP-seq
MIRT2448035	hsa-miR-411	CLIP-seq
MIRT2209073	hsa-miR-4418	CLIP-seq
MIRT2209074	hsa-miR-4421	CLIP-seq
MIRT2512930	hsa-miR-4423-5p	CLIP-seq
MIRT1973510	hsa-miR-4430	CLIP-seq
MIRT2512934	hsa-miR-4684-3p	CLIP-seq
MIRT1973511	hsa-miR-4715-3p	CLIP-seq
MIRT2512935	hsa-miR-4716-5p	CLIP-seq
MIRT1973512	hsa-miR-4735-5p	CLIP-seq
MIRT1973513	hsa-miR-4775	CLIP-seq
MIRT2209076	hsa-miR-509-3-5p	CLIP-seq
MIRT2209077	hsa-miR-509-5p	CLIP-seq
MIRT2512936	hsa-miR-5096	CLIP-seq
MIRT2512938	hsa-miR-518a-5p	CLIP-seq
MIRT2209078	hsa-miR-520a-5p	CLIP-seq
MIRT2209079	hsa-miR-525-5p	CLIP-seq
MIRT2512947	hsa-miR-527	CLIP-seq
MIRT1973514	hsa-miR-590-3p	CLIP-seq
MIRT2209082	hsa-miR-657	CLIP-seq
MIRT2209083	hsa-miR-660	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ELK1	Unknown	19536094
ESRRA	Unknown	19536094

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IMP	39701103
GO:0003924	Function	GTPase activity	IMP	39701103
GO:0005515	Function	Protein binding	IPI	19103604, 20563667, 30021884, 33961781
GO:0005525	Function	GTP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	20563667
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005761	Component	Mitochondrial ribosome	IEA
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	25838379
GO:0005840	Component	Ribosome	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008637	Process	Apoptotic mitochondrial changes	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032543	Process	Mitochondrial translation	IMP	39701103
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:0097190	Process	Apoptotic signaling pathway	TAS	7499268
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
602074	2673	ENSG00000132676

Protein

UniProt ID

P51398

Protein name

Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein)

Protein function

As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vit

PDB

3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10236	DAP3	99 → 394	Mitochondrial ribosomal death-associated protein 3	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MMLKGITRLISRIHKLDPGRFLHMGTQARQSIAAHLDNQVPVESPRAISRTNENDPAKHG
DQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLMVRKPALELLHYLKNTSFAYP
AIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQ
PLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAV
GIVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMKND
WHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDALDPFIPILVSNYNPKEFESCIQYY
LENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL

Sequence length

398

Interactions

View interactions

	Reactome
			Mitochondrial translation elongation Mitochondrial translation termination

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	26356813, 33401559, 37023702
Ataxia Telangiectasia	Associate	20079882
Breast Neoplasms	Associate	36382667
Carcinoma Hepatocellular	Associate	36028814, 36769187, 37400785
Cerebral Infarction	Associate	31436916
Colorectal Neoplasms	Associate	36382667
Gastritis Atrophic	Associate	17366642
Glioma	Associate	20079882
Neoplasms	Stimulate	19536094
Neoplasms	Associate	24150215, 32596459, 36382667
Stomach Neoplasms	Associate	24300973
Stroke	Associate	31436916
Thyroid Neoplasms	Associate	19536094

DAP3 (death associated protein 3)