Gene Gene information from NCBI Gene database.
Entrez ID 7803
Gene name Protein tyrosine phosphatase 4A1
Gene symbol PTP4A1
Synonyms (NCBI Gene)
HH72PRL-1PRL1PTP(CAAX1)PTPCAAX1
Chromosome 6
Chromosome location 6q12
Summary This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a
miRNA miRNA information provided by mirtarbase database.
1413
miRTarBase ID miRNA Experiments Reference
MIRT020207 hsa-miR-130b-3p Sequencing 20371350
MIRT022499 hsa-miR-124-3p Microarray 18668037
MIRT028544 hsa-miR-30a-5p Proteomics 18668040
MIRT029304 hsa-miR-26b-5p Sequencing 20371350
MIRT031146 hsa-miR-19b-3p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
EGR1 Unknown 9988683
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity NAS 10569806
GO:0005515 Function Protein binding IPI 27880917, 28330616, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601585 9634 ENSG00000112245
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q93096
Protein name Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
Protein function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive acti
PDB 1RXD , 1XM2 , 5BX1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 26 153 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:12235145}.
Sequence
Sequence length 173
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 16832410, 27377268, 30252041
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 25003523
★☆☆☆☆
Found in Text Mining only
Cholangiocarcinoma Associate 33502823
★☆☆☆☆
Found in Text Mining only
Choroidal Effusions Associate 21541048
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 35137928
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Associate 38134119
★☆☆☆☆
Found in Text Mining only
Esophageal Squamous Cell Carcinoma Associate 18684031
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 35872698
★☆☆☆☆
Found in Text Mining only
Glioma Associate 35872698
★☆☆☆☆
Found in Text Mining only
Glioma of Brain Familial Associate 35872698
★☆☆☆☆
Found in Text Mining only