Gene Gene information from NCBI Gene database.
Entrez ID 7789
Gene name Zinc finger X-linked duplicated A
Gene symbol ZXDA
Synonyms (NCBI Gene)
ZNF896
Chromosome X
Chromosome location Xp11.21
Summary This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 ta
miRNA miRNA information provided by mirtarbase database.
778
miRTarBase ID miRNA Experiments Reference
MIRT028293 hsa-miR-32-5p Sequencing 20371350
MIRT039439 hsa-miR-421 CLASH 23622248
MIRT241085 hsa-miR-3606-3p HITS-CLIP 21572407
MIRT241077 hsa-miR-513a-3p HITS-CLIP 21572407
MIRT241081 hsa-miR-513c-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity IBA
GO:0003713 Function Transcription coactivator activity IEA
GO:0003713 Function Transcription coactivator activity IMP 17493635
GO:0005515 Function Protein binding IPI 17493635, 17696781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300235 13198 ENSG00000198205
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P98168
Protein name Zinc finger X-linked protein ZXDA
Protein function Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 300 324 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 330 354 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 359 385 Domain
PF00096 zf-C2H2 480 504 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta. {ECO:0000269|PubMed:8268913}.
Sequence
MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLPRGPQDGGPGRRRE
EASTASRGPGPSLFAPRPHQPSGGGDDFFLVLLDPVGGDVETAGSGQAAGPVLREEAKAG
PGLQGDESGANPAGCSAQGPHCLSAVPTPAPISAPGPAAAFAGTVTIHNQDLLLRFENGV
LTLATPPPHAWEPGAAPAQQPRCLIAPQAGFPQAAHPGDCPELRSDLLLAEPAEPAPAPA
PQEEAEGLAAALGPRGLLGSGPGVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRPF
KCPLGGCGWTFTTSYKLKRHLQSH
DKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSF
KCEVCEESFPTQAKLGAHQRSHFEP
ERPYQCAFSGCKKTFITVSALFSHNRAHFREQELF
SCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRF
MCPVEGCGKSFTRAEHLKGHSITH
LGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDT
WKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSD
AEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPS
LMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQAL
TPSSKLTVDTDTLTPSSTLCENSVSELLTPAKAEWSVHPNSDFFGQEGETQFGFPNAAGN
HGSQKERNLITVTGSSFLV
Sequence length 799
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Fraser syndrome 3 Uncertain significance ClinVar
Disgenet
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
HYPOGONADISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations