Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7781
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 30 member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC30A3
Synonyms (NCBI Gene) Gene synonyms aliases	ZNT3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.3

Show/Hide all(176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT634030	hsa-miR-548aa	HITS-CLIP	23824327
MIRT634029	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT634028	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT634030	hsa-miR-548aa	HITS-CLIP	23824327
MIRT634029	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT634028	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT634030	hsa-miR-548aa	HITS-CLIP	23824327
MIRT634029	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT634028	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT666287	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT634030	hsa-miR-548aa	HITS-CLIP	23824327
MIRT634029	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT634028	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT666286	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT653635	hsa-miR-7846-3p	HITS-CLIP	23824327
MIRT653633	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT653632	hsa-miR-4270	HITS-CLIP	23824327
MIRT653631	hsa-miR-4441	HITS-CLIP	23824327
MIRT653630	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT653629	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653627	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT653628	hsa-miR-4469	HITS-CLIP	23824327
MIRT653626	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT666285	hsa-miR-1184	HITS-CLIP	23824327
MIRT653625	hsa-miR-1289	HITS-CLIP	23824327
MIRT653624	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT653623	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT653622	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT653635	hsa-miR-7846-3p	HITS-CLIP	23824327
MIRT653633	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT653632	hsa-miR-4270	HITS-CLIP	23824327
MIRT653631	hsa-miR-4441	HITS-CLIP	23824327
MIRT653630	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT653629	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653627	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT653628	hsa-miR-4469	HITS-CLIP	23824327
MIRT653626	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653625	hsa-miR-1289	HITS-CLIP	23824327
MIRT653624	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT653623	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT653622	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT634030	hsa-miR-548aa	HITS-CLIP	23824327
MIRT634029	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT634028	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	23824327
MIRT607465	hsa-miR-8485	HITS-CLIP	24906430
MIRT576714	hsa-miR-548aa	HITS-CLIP	27418678
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	27418678
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	27418678
MIRT576711	hsa-miR-8485	HITS-CLIP	27418678
MIRT576711	hsa-miR-8485	HITS-CLIP	27418678
MIRT734618	hsa-miR-5572	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR	32599739
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT576714	hsa-miR-548aa	HITS-CLIP	23824327
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT576714	hsa-miR-548aa	HITS-CLIP	23824327
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT576714	hsa-miR-548aa	HITS-CLIP	23824327
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT666287	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT576714	hsa-miR-548aa	HITS-CLIP	23824327
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT666286	hsa-miR-497-3p	HITS-CLIP	23824327
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT653635	hsa-miR-7846-3p	HITS-CLIP	23824327
MIRT653633	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT653632	hsa-miR-4270	HITS-CLIP	23824327
MIRT653631	hsa-miR-4441	HITS-CLIP	23824327
MIRT653630	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT653629	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653627	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT653628	hsa-miR-4469	HITS-CLIP	23824327
MIRT653626	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT666285	hsa-miR-1184	HITS-CLIP	23824327
MIRT653625	hsa-miR-1289	HITS-CLIP	23824327
MIRT653624	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT653623	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT653622	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT653635	hsa-miR-7846-3p	HITS-CLIP	23824327
MIRT653633	hsa-miR-211-3p	HITS-CLIP	23824327
MIRT653632	hsa-miR-4270	HITS-CLIP	23824327
MIRT653631	hsa-miR-4441	HITS-CLIP	23824327
MIRT653630	hsa-miR-6754-5p	HITS-CLIP	23824327
MIRT653629	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653627	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT653628	hsa-miR-4469	HITS-CLIP	23824327
MIRT653626	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653625	hsa-miR-1289	HITS-CLIP	23824327
MIRT653624	hsa-miR-3127-5p	HITS-CLIP	23824327
MIRT653623	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT653622	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT576714	hsa-miR-548aa	HITS-CLIP	23824327
MIRT576713	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT576712	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT576711	hsa-miR-8485	HITS-CLIP	23824327
MIRT1359120	hsa-miR-1193	CLIP-seq
MIRT1359121	hsa-miR-1207-5p	CLIP-seq
MIRT1359122	hsa-miR-29a	CLIP-seq
MIRT1359123	hsa-miR-29b	CLIP-seq
MIRT1359124	hsa-miR-29c	CLIP-seq
MIRT1359125	hsa-miR-3065-3p	CLIP-seq
MIRT1359126	hsa-miR-3165	CLIP-seq
MIRT1359127	hsa-miR-342-5p	CLIP-seq
MIRT1359128	hsa-miR-34a	CLIP-seq
MIRT1359129	hsa-miR-34c-5p	CLIP-seq
MIRT1359130	hsa-miR-3616-3p	CLIP-seq
MIRT1359131	hsa-miR-376c	CLIP-seq
MIRT1359132	hsa-miR-3918	CLIP-seq
MIRT1359133	hsa-miR-4313	CLIP-seq
MIRT1359134	hsa-miR-4436b-3p	CLIP-seq
MIRT1359135	hsa-miR-449a	CLIP-seq
MIRT1359136	hsa-miR-449b	CLIP-seq
MIRT1359137	hsa-miR-4514	CLIP-seq
MIRT1359138	hsa-miR-4633-3p	CLIP-seq
MIRT1359139	hsa-miR-4643	CLIP-seq
MIRT1359140	hsa-miR-4651	CLIP-seq
MIRT1359141	hsa-miR-4662a-5p	CLIP-seq
MIRT1359142	hsa-miR-4664-5p	CLIP-seq
MIRT1359143	hsa-miR-4692	CLIP-seq
MIRT1359144	hsa-miR-4710	CLIP-seq
MIRT1359145	hsa-miR-4717-3p	CLIP-seq
MIRT1359146	hsa-miR-4721	CLIP-seq
MIRT1359147	hsa-miR-4731-3p	CLIP-seq
MIRT1359148	hsa-miR-4763-3p	CLIP-seq
MIRT1359149	hsa-miR-4801	CLIP-seq
MIRT1359150	hsa-miR-4802-3p	CLIP-seq
MIRT1359151	hsa-miR-490-5p	CLIP-seq
MIRT1359152	hsa-miR-558	CLIP-seq
MIRT1359153	hsa-miR-608	CLIP-seq
MIRT1359154	hsa-miR-642a	CLIP-seq
MIRT1359155	hsa-miR-642b	CLIP-seq
MIRT2106343	hsa-miR-1972	CLIP-seq
MIRT1359122	hsa-miR-29a	CLIP-seq
MIRT1359123	hsa-miR-29b	CLIP-seq
MIRT1359124	hsa-miR-29c	CLIP-seq
MIRT1359125	hsa-miR-3065-3p	CLIP-seq
MIRT1359126	hsa-miR-3165	CLIP-seq
MIRT2106344	hsa-miR-3622a-5p	CLIP-seq
MIRT2106345	hsa-miR-4423-3p	CLIP-seq
MIRT1359138	hsa-miR-4633-3p	CLIP-seq
MIRT1359141	hsa-miR-4662a-5p	CLIP-seq
MIRT2106346	hsa-miR-4717-5p	CLIP-seq
MIRT1359147	hsa-miR-4731-3p	CLIP-seq
MIRT1359149	hsa-miR-4801	CLIP-seq
MIRT1359152	hsa-miR-558	CLIP-seq
MIRT1359154	hsa-miR-642a	CLIP-seq
MIRT1359122	hsa-miR-29a	CLIP-seq
MIRT1359123	hsa-miR-29b	CLIP-seq
MIRT1359124	hsa-miR-29c	CLIP-seq
MIRT1359125	hsa-miR-3065-3p	CLIP-seq
MIRT2442637	hsa-miR-1224-3p	CLIP-seq
MIRT2442638	hsa-miR-1260	CLIP-seq
MIRT2442639	hsa-miR-1260b	CLIP-seq
MIRT2442640	hsa-miR-1280	CLIP-seq
MIRT2442641	hsa-miR-4258	CLIP-seq
MIRT2442642	hsa-miR-4286	CLIP-seq
MIRT2459663	hsa-miR-4283	CLIP-seq
MIRT2459664	hsa-miR-4489	CLIP-seq
MIRT2459665	hsa-miR-4492	CLIP-seq
MIRT2459666	hsa-miR-4498	CLIP-seq
MIRT2459667	hsa-miR-4505	CLIP-seq
MIRT2459668	hsa-miR-4656	CLIP-seq
MIRT2459669	hsa-miR-4731-5p	CLIP-seq
MIRT2459670	hsa-miR-762	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005385	Function	Zinc ion transmembrane transporter activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 25657003, 26728129, 32296183
GO:0005737	Component	Cytoplasm	IDA	17349999
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	TAS	8962159
GO:0005770	Component	Late endosome	IDA	17349999
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	TAS	8962159
GO:0008021	Component	Synaptic vesicle	IDA	26647834
GO:0010043	Process	Response to zinc ion	IBA	21873635
GO:0015633	Function	ABC-type zinc transporter activity	TAS	8962159
GO:0016020	Component	Membrane	TAS	8962159
GO:0030285	Component	Integral component of synaptic vesicle membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0043005	Component	Neuron projection	ISS
GO:0051050	Process	Positive regulation of transport	IEA
GO:0061088	Process	Regulation of sequestering of zinc ion	IBA	21873635
GO:0061088	Process	Regulation of sequestering of zinc ion	IDA	17349999
GO:0071577	Process	Zinc ion transmembrane transport	IBA	21873635
GO:0097457	Component	Hippocampal mossy fiber	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099180	Process	Zinc ion import into synaptic vesicle	IEA

MIM	HGNC	e!Ensembl
602878	11014	ENSG00000115194

Protein

UniProt ID

Q99726

Protein name

Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3)

Protein function

Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain. {ECO:0000269|PubMed:17349999, ECO:0000269|PubMed:19521526, ECO:000026

PDB

8XN1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01545	Cation_efflux	76 → 293	Cation efflux family	Family

Sequence

MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPL
PPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSL
FSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAM
LLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVL
GDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNV
GFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRF
GFSSCTLQVEQYQPEMAQCLRCQEPPQA

Sequence length

388

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	27790247
Diabetes	Diabetes	rs80356611	27790247
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	27790247
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	23849395

Show/Hide Unknown Diseases (3)

Disease term	Disease name	References	Source
Unknown
Coronary heart disease	Coronary heart disease	27790247	ClinVar
Heart failure	Heart failure	27790247	ClinVar
Alzheimer disease	Alzheimer disease		GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Inhibit	22640423
Amyotrophic lateral sclerosis 1	Inhibit	32599739
Depressive Disorder Major	Inhibit	27661418
Neoplasms	Associate	39596116
Zinc Deficiency Neonatal due to Low Breast Milk Zinc	Associate	25657003

SLC30A3 (solute carrier family 30 member 3)