Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7764
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger protein 217
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZNF217
Synonyms (NCBI Gene) Gene synonyms aliases
ZABC1
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007012 hsa-miR-24-3p Luciferase reporter assay 22815235
MIRT007012 hsa-miR-24-3p Luciferase reporter assay 22815235
MIRT020307 hsa-miR-130b-3p Sequencing 20371350
MIRT028154 hsa-miR-93-5p Sequencing 20371350
MIRT028190 hsa-miR-33a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
HIF1A Activation 21483406
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000118 Component Histone deacetylase complex IDA 18625718
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 17130829
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 18625718
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 17130829
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602967 13009 ENSG00000171940
Protein
UniProt ID O75362
Protein name Zinc finger protein 217
Protein function Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubM
PDB 2HU2 , 3UK3 , 4F2J , 4IS1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 128 150 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 156 178 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 472 493 Zinc finger, C2H2 type Domain
Sequence
MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIE
GYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKE
KNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNG
KSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTK
KTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQ
LATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPS
VDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTC
SPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFF
RSNYYLNIHLRTH
TGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQ
DTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQ
DFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLE
VSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTF
YPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAF
PAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSE
MFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYF
CNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCV
YPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQ
HLSNSMAQKRNYENFIGNAHYRPNDKKT
Sequence length 1048
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Estrogen-dependent gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Asthma Asthma GWAS
Diabetes Diabetes GWAS
Dermatitis Dermatitis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Clear Cell Associate 25658832
Adenoma Associate 30229897
Breast Neoplasms Associate 18625718, 18628976, 24962896, 24973012, 25871474, 26008969, 26094658, 27506935, 27539783, 34836952, 9671742
Breast Neoplasms Male Associate 24194916
Carcinogenesis Associate 24962896, 25621839, 30229897
Carcinoma Ovarian Epithelial Associate 18661515
Colorectal Neoplasms Associate 20966547, 24204606, 25621839
Colorectal Neoplasms Stimulate 25824781
Endodermal Sinus Tumor Associate 34117242
Esophageal Squamous Cell Carcinoma Associate 31851786