Gene Gene information from NCBI Gene database.
Entrez ID 7757
Gene name Zinc finger protein 208
Gene symbol ZNF208
Synonyms (NCBI Gene)
PMIDPZNF95
Chromosome 19
Chromosome location 19p12
Summary Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated
miRNA miRNA information provided by mirtarbase database.
802
miRTarBase ID miRNA Experiments Reference
MIRT004214 hsa-miR-197-3p Microarray 16822819
MIRT683854 hsa-miR-218-2-3p HITS-CLIP 23313552
MIRT683853 hsa-miR-758-5p HITS-CLIP 23313552
MIRT683851 hsa-miR-4724-3p HITS-CLIP 23313552
MIRT683850 hsa-miR-584-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003677 Function DNA binding IEA
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0006355 Process Regulation of DNA-templated transcription IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603977 12999 ENSG00000160321
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43345
Protein name Zinc finger protein 208 (Zinc finger protein 91-like)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 3 44 KRAB box Family
PF13912 zf-C2H2_6 229 251 Domain
PF00096 zf-C2H2 257 279 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 286 307 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 313 335 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 341 363 Domain
PF00096 zf-C2H2 425 447 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 497 519 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 525 547 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 581 603 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 609 631 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 637 659 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 665 687 Domain
PF00096 zf-C2H2 693 715 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 721 743 Domain
PF00096 zf-C2H2 777 799 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 805 827 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 833 855 Domain
PF00096 zf-C2H2 945 967 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1001 1023 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1029 1051 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1085 1107 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1113 1135 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 1225 1247 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MGSLTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAFKPDLIIFLEEGK
ESWNMKRHEMVEESPVICSHFAQDLWPEQGIEDSFQKVILRRYEKCGHENLHLKIGYTNV
DECKVHKEGYNKLNQSLTTTQSKVFQRGKYANVFHKCSNSNRHKIRHTGKKHLQCKEYVR
SFCMLSHLSQHKRIYTRENSYKCEEGGKAFNWSSTLTYYKSAHTGEKPYRCKECGKAFSK
FSILTKHKVIH
TGEKSYKCEECGKAFNQSAILTKHKIIHTGEKPNKCEECGKAFSKVSTL
TTHKAIH
AGEKPYKCKECGKAFSKVSTLITHKAIHAGEKPYKCKECGKAFSKFSILTKHK
VIH
TGEKPYKCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSILTKHEVIHT
GEKPYKCEECGKAFNWSSNLMEHKKIHTGETPYKCEECGKGFSMFSILTKHKVIHNGEKP
YKCEECDKATHAGEKPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSIL
TKHKVIH
TGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKAFNQSAILIKHK
RIH
TGEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKTFIKVSTLTTHKAIHA
GEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKRIHTGEKP
YKCEECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCE
ECGKAFNRSAILIKHKRIH
TDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGK
AFSKFSILTKHKVIH
TGEKPYKCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSM
FSILTKHEVIHTGEKPYKCEECGKAFSWLSVFSKHKKTHAGEKFYKCEACGKAYKSSSTL
SYHKKIH
TEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHK
KIH
TGETPYKCEECDKAFSWPSSLTEHKATHAGEKPYKCEECGKAFSWPSRLTEHKATHA
GEEPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKP
YKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSILAKHKVIHTGEKLYKCE
ECGKAYKWPSTLRYHKKIHTGEKPYKCEECGKAFSTFSILTKHKVIHTGEKPYKCEECGK
AFSWLSVFSKHKKIHTGEKL
Sequence length 1280
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHAGAS CARDIOMYOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CIC-rearranged sarcoma not provided ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Esophageal Neoplasms Associate 27907911
★☆☆☆☆
Found in Text Mining only
Leukemia Associate 27207662
★☆☆☆☆
Found in Text Mining only
Leukocyte Disorders Associate 31388112
★☆☆☆☆
Found in Text Mining only
Liver Neoplasms Associate 30931641
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Associate 27207662
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Associate 26330360, 27907911
★☆☆☆☆
Found in Text Mining only