ZNF185 (zinc finger protein 185 with LIM domain)

Gene

• Entrez ID: 7739
• Gene name: Zinc finger protein 185 with LIM domain
• Gene symbol: ZNF185
• Synonyms (NCBI Gene): SCELL
• Chromosome: X
• Chromosome location: Xq28
• Summary: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT689983	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT689982	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT689981	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT689980	hsa-miR-3183	HITS-CLIP	23313552
MIRT689979	hsa-miR-4723-3p	HITS-CLIP	23313552
MIRT689978	hsa-miR-6769b-3p	HITS-CLIP	23313552
MIRT689977	hsa-miR-1283	HITS-CLIP	23313552
MIRT689976	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT689975	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT689974	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT689973	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT689972	hsa-miR-3921	HITS-CLIP	23313552
MIRT689971	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT689970	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT689969	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT689968	hsa-miR-206	HITS-CLIP	23313552
MIRT689967	hsa-miR-613	HITS-CLIP	23313552
MIRT689966	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT689965	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT689964	hsa-miR-4736	HITS-CLIP	23313552
MIRT689963	hsa-miR-4326	HITS-CLIP	23313552
MIRT689962	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT689961	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT689960	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT689959	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT689958	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT689957	hsa-miR-7150	HITS-CLIP	23313552
MIRT689956	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT689955	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT689954	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT689953	hsa-miR-4436b-3p	HITS-CLIP	23313552
MIRT689983	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT689982	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT689981	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT689980	hsa-miR-3183	HITS-CLIP	23313552
MIRT689979	hsa-miR-4723-3p	HITS-CLIP	23313552
MIRT689978	hsa-miR-6769b-3p	HITS-CLIP	23313552
MIRT689977	hsa-miR-1283	HITS-CLIP	23313552
MIRT689976	hsa-miR-6817-3p	HITS-CLIP	23313552
MIRT689975	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT689974	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT689973	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT689972	hsa-miR-3921	HITS-CLIP	23313552
MIRT689971	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT689970	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT689969	hsa-miR-1-3p	HITS-CLIP	23313552
MIRT689968	hsa-miR-206	HITS-CLIP	23313552
MIRT689967	hsa-miR-613	HITS-CLIP	23313552
MIRT689966	hsa-miR-1207-5p	HITS-CLIP	23313552
MIRT689965	hsa-miR-4763-3p	HITS-CLIP	23313552
MIRT689964	hsa-miR-4736	HITS-CLIP	23313552
MIRT689963	hsa-miR-4326	HITS-CLIP	23313552
MIRT689962	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT689961	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT689960	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT689959	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT689958	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT689957	hsa-miR-7150	HITS-CLIP	23313552
MIRT689956	hsa-miR-182-5p	HITS-CLIP	23313552
MIRT689955	hsa-miR-1271-5p	HITS-CLIP	23313552
MIRT689954	hsa-miR-96-5p	HITS-CLIP	23313552
MIRT689953	hsa-miR-4436b-3p	HITS-CLIP	23313552
MIRT1517259	hsa-miR-4475	CLIP-seq
MIRT1517260	hsa-miR-4643	CLIP-seq
MIRT1517261	hsa-miR-103b	CLIP-seq
MIRT1517262	hsa-miR-1207-3p	CLIP-seq
MIRT1517263	hsa-miR-1225-5p	CLIP-seq
MIRT1517264	hsa-miR-124	CLIP-seq
MIRT1517265	hsa-miR-1253	CLIP-seq
MIRT1517266	hsa-miR-1343	CLIP-seq
MIRT1517267	hsa-miR-155	CLIP-seq
MIRT1517268	hsa-miR-21	CLIP-seq
MIRT1517269	hsa-miR-2117	CLIP-seq
MIRT1517270	hsa-miR-27a	CLIP-seq
MIRT1517271	hsa-miR-27b	CLIP-seq
MIRT1517272	hsa-miR-3064-3p	CLIP-seq
MIRT1517273	hsa-miR-3074-5p	CLIP-seq
MIRT1517274	hsa-miR-3115	CLIP-seq
MIRT1517275	hsa-miR-3125	CLIP-seq
MIRT1517276	hsa-miR-3154	CLIP-seq
MIRT1517277	hsa-miR-3159	CLIP-seq
MIRT1517278	hsa-miR-3171	CLIP-seq
MIRT1517279	hsa-miR-3190	CLIP-seq
MIRT1517280	hsa-miR-3591-5p	CLIP-seq
MIRT1517281	hsa-miR-3612	CLIP-seq
MIRT1517282	hsa-miR-3616-3p	CLIP-seq
MIRT1517283	hsa-miR-365	CLIP-seq
MIRT1517284	hsa-miR-3675-5p	CLIP-seq
MIRT1517285	hsa-miR-3690	CLIP-seq
MIRT1517286	hsa-miR-3714	CLIP-seq
MIRT1517287	hsa-miR-3910	CLIP-seq
MIRT1517288	hsa-miR-3916	CLIP-seq
MIRT1517289	hsa-miR-4252	CLIP-seq
MIRT1517290	hsa-miR-4254	CLIP-seq
MIRT1517291	hsa-miR-4264	CLIP-seq
MIRT1517292	hsa-miR-4273	CLIP-seq
MIRT1517293	hsa-miR-4290	CLIP-seq
MIRT1517294	hsa-miR-4305	CLIP-seq
MIRT1517295	hsa-miR-4320	CLIP-seq
MIRT1517296	hsa-miR-4328	CLIP-seq
MIRT1517297	hsa-miR-4422	CLIP-seq
MIRT1517298	hsa-miR-4443	CLIP-seq
MIRT1517299	hsa-miR-4450	CLIP-seq
MIRT1517300	hsa-miR-4457	CLIP-seq
MIRT1517301	hsa-miR-4481	CLIP-seq
MIRT1517302	hsa-miR-4633-3p	CLIP-seq
MIRT1517303	hsa-miR-4661-5p	CLIP-seq
MIRT1517304	hsa-miR-4662a-3p	CLIP-seq
MIRT1517305	hsa-miR-4677-3p	CLIP-seq
MIRT1517306	hsa-miR-4679	CLIP-seq
MIRT1517307	hsa-miR-4715-3p	CLIP-seq
MIRT1517308	hsa-miR-4720-3p	CLIP-seq
MIRT1517309	hsa-miR-4721	CLIP-seq
MIRT1517310	hsa-miR-4745-5p	CLIP-seq
MIRT1517311	hsa-miR-4758-5p	CLIP-seq
MIRT1517312	hsa-miR-4762-5p	CLIP-seq
MIRT1517313	hsa-miR-4764-5p	CLIP-seq
MIRT1517314	hsa-miR-4766-5p	CLIP-seq
MIRT1517315	hsa-miR-4795-3p	CLIP-seq
MIRT1517316	hsa-miR-4797-3p	CLIP-seq
MIRT1517317	hsa-miR-487a	CLIP-seq
MIRT1517318	hsa-miR-488	CLIP-seq
MIRT1517319	hsa-miR-506	CLIP-seq
MIRT1517320	hsa-miR-513a-5p	CLIP-seq
MIRT1517321	hsa-miR-513b	CLIP-seq
MIRT1517322	hsa-miR-520a-5p	CLIP-seq
MIRT1517323	hsa-miR-525-5p	CLIP-seq
MIRT1517324	hsa-miR-580	CLIP-seq
MIRT1517325	hsa-miR-590-5p	CLIP-seq
MIRT1517326	hsa-miR-648	CLIP-seq
MIRT1517327	hsa-miR-650	CLIP-seq
MIRT1517328	hsa-miR-7	CLIP-seq
MIRT1517329	hsa-miR-891b	CLIP-seq
MIRT2156168	hsa-miR-4521	CLIP-seq
MIRT2156169	hsa-miR-4668-3p	CLIP-seq
MIRT2156170	hsa-miR-4793-3p	CLIP-seq
MIRT1517263	hsa-miR-1225-5p	CLIP-seq
MIRT1517267	hsa-miR-155	CLIP-seq
MIRT2375750	hsa-miR-199a-3p	CLIP-seq
MIRT2375751	hsa-miR-199b-3p	CLIP-seq
MIRT1517270	hsa-miR-27a	CLIP-seq
MIRT1517271	hsa-miR-27b	CLIP-seq
MIRT1517274	hsa-miR-3115	CLIP-seq
MIRT1517275	hsa-miR-3125	CLIP-seq
MIRT2375752	hsa-miR-3127-5p	CLIP-seq
MIRT2375753	hsa-miR-3129-5p	CLIP-seq
MIRT1517277	hsa-miR-3159	CLIP-seq
MIRT2375754	hsa-miR-329	CLIP-seq
MIRT2375755	hsa-miR-34c-3p	CLIP-seq
MIRT2375756	hsa-miR-362-3p	CLIP-seq
MIRT1517283	hsa-miR-365	CLIP-seq
MIRT2375757	hsa-miR-3664-5p	CLIP-seq
MIRT1517284	hsa-miR-3675-5p	CLIP-seq
MIRT2375758	hsa-miR-383	CLIP-seq
MIRT1517288	hsa-miR-3916	CLIP-seq
MIRT2375759	hsa-miR-3941	CLIP-seq
MIRT2375760	hsa-miR-4270	CLIP-seq
MIRT1517292	hsa-miR-4273	CLIP-seq
MIRT1517293	hsa-miR-4290	CLIP-seq
MIRT2375761	hsa-miR-4441	CLIP-seq
MIRT1517299	hsa-miR-4450	CLIP-seq
MIRT1517260	hsa-miR-4643	CLIP-seq
MIRT2156169	hsa-miR-4668-3p	CLIP-seq
MIRT2375762	hsa-miR-4714-5p	CLIP-seq
MIRT2375763	hsa-miR-4731-3p	CLIP-seq
MIRT1517312	hsa-miR-4762-5p	CLIP-seq
MIRT2375764	hsa-miR-4772-5p	CLIP-seq
MIRT1517315	hsa-miR-4795-3p	CLIP-seq
MIRT2375765	hsa-miR-4801	CLIP-seq
MIRT1517320	hsa-miR-513a-5p	CLIP-seq
MIRT1517322	hsa-miR-520a-5p	CLIP-seq
MIRT1517323	hsa-miR-525-5p	CLIP-seq
MIRT2375766	hsa-miR-603	CLIP-seq
MIRT2375767	hsa-miR-606	CLIP-seq
MIRT2375768	hsa-miR-885-5p	CLIP-seq
MIRT2375769	hsa-miR-9	CLIP-seq
MIRT2375770	hsa-miR-936	CLIP-seq
MIRT2695763	hsa-miR-1236	CLIP-seq
MIRT2695764	hsa-miR-2276	CLIP-seq
MIRT2695765	hsa-miR-4330	CLIP-seq
MIRT2695766	hsa-miR-4772-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0008270	Function	Zinc ion binding	TAS	9268636
GO:0046872	Function	Metal ion binding	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 300381
• HGNC: 12976
• e!Ensembl: ENSG00000147394

Protein

• UniProt ID: O15231
• Protein name: Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)
• Protein function: May be involved in the regulation of cellular proliferation and/or differentiation.
• Tissue specificity: TISSUE SPECIFICITY: Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood.
• Sequence:

  MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS
  RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR
  TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA
  ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS
  TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD
  VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE
  GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA
  WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA
  TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS
  SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV
  SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI
  CSKPMGDLLDQIFIHRDTIHCGKCYEKLF

• Sequence length: 689

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Associate	27768594	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	35111149	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	30337687	★☆☆☆☆ Found in Text Mining only
Infertility Male	Associate	39267058	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	30446632	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Inhibit	30337687	★☆☆☆☆ Found in Text Mining only