Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7727
Gene name	Zinc finger protein 174
Gene symbol	ZNF174
Synonyms (NCBI Gene)	ZSCAN8
Chromosome	16
Chromosome location	16p13.3
Summary	This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor.

Show/Hide all (82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049596	hsa-miR-92a-3p	CLASH	23622248
MIRT037309	hsa-miR-877-5p	CLASH	23622248
MIRT695947	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT695946	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT695945	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT695944	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT695943	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT695942	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT695941	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT695940	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT695939	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT695938	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT695937	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT695936	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT695935	hsa-miR-302e	HITS-CLIP	23313552
MIRT695934	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT695933	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT695932	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT695931	hsa-miR-520b	HITS-CLIP	23313552
MIRT695930	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT695929	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT695928	hsa-miR-520e	HITS-CLIP	23313552
MIRT695927	hsa-miR-6819-3p	HITS-CLIP	23313552
MIRT695926	hsa-miR-6877-3p	HITS-CLIP	23313552
MIRT695924	hsa-miR-3159	HITS-CLIP	23313552
MIRT695925	hsa-miR-3973	HITS-CLIP	23313552
MIRT695923	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT695922	hsa-miR-520h	HITS-CLIP	23313552
MIRT695921	hsa-miR-6752-3p	HITS-CLIP	23313552
MIRT695920	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT695919	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT695918	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT695917	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT695916	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT695915	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT695947	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT695946	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT695945	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT695944	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT695943	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT695942	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT695941	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT695940	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT695939	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT695938	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT695937	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT695936	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT695935	hsa-miR-302e	HITS-CLIP	23313552
MIRT695934	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT695933	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT695932	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT695931	hsa-miR-520b	HITS-CLIP	23313552
MIRT695930	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT695929	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT695928	hsa-miR-520e	HITS-CLIP	23313552
MIRT695927	hsa-miR-6819-3p	HITS-CLIP	23313552
MIRT695926	hsa-miR-6877-3p	HITS-CLIP	23313552
MIRT695924	hsa-miR-3159	HITS-CLIP	23313552
MIRT695925	hsa-miR-3973	HITS-CLIP	23313552
MIRT695923	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT695922	hsa-miR-520h	HITS-CLIP	23313552
MIRT695921	hsa-miR-6752-3p	HITS-CLIP	23313552
MIRT695920	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT695919	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT695918	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT695917	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT695916	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT695915	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT1517118	hsa-miR-1185	CLIP-seq
MIRT1517119	hsa-miR-1303	CLIP-seq
MIRT1517120	hsa-miR-3125	CLIP-seq
MIRT1517121	hsa-miR-3126-5p	CLIP-seq
MIRT1517122	hsa-miR-3679-5p	CLIP-seq
MIRT1517123	hsa-miR-3916	CLIP-seq
MIRT1517124	hsa-miR-4422	CLIP-seq
MIRT1517125	hsa-miR-877	CLIP-seq
MIRT2375682	hsa-miR-4666-5p	CLIP-seq
MIRT2375683	hsa-miR-502-5p	CLIP-seq
MIRT2375684	hsa-miR-758	CLIP-seq
MIRT2397445	hsa-miR-4297	CLIP-seq
MIRT2397446	hsa-miR-4753-3p	CLIP-seq
MIRT2397447	hsa-miR-942	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	7673192
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	7673192
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	7673192
GO:0005515	Function	Protein binding	IPI	20211142, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	7673192
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0042803	Function	Protein homodimerization activity	IPI	15629724
GO:0043565	Function	Sequence-specific DNA binding	IDA	28473536
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	7673192
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
603900	12963	ENSG00000103343

Q15697

Protein name

Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)

Protein function

Transcriptional repressor.

PDB

1Y7Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	42 → 131	SCAN domain	Domain
PF00096	zf-C2H2	326 → 348	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	354 → 376	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	382 → 405	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelia

Sequence

MAAKMEITLSSNTEASSKQERHIIAKLEEKRGPPLQKNCPDPELCRQSFRRFCYQEVSGP
QEALSQLRQLCRQWLQPELHTKEQILELLVMEQFLTILPPEIQARVRHRCPMSSKEIVTL
VEDFHRASKKPKQWVAVCMQGQKVLLEKTGSQLGEQELPDFQPQTPRRDLRESSPAEPSQ
AGAYDRLSPHHWEKSPLLQEPTPKLAGTEAPRMRSDNKENPQQEGAKGAKPCAVSAGRSK
GNGLQNPEPRGANMSEPRLSRRQVSSPNAQKPFAHYQRHCRVEYISSPLKSHPLRELKKS
KGGKRSLSNRLQHLGHQPTRSAKKPYKCDDCGKSFTWNSELKRHKRVHTGERPYTCGECG
NCFGRQSTLKLHQRIHTGEKPYQCGQCGKSFRQSSNLHQHHRLHHGD

Sequence length

407

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF174 (zinc finger protein 174)