Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7690
Gene name	Zinc finger protein 131
Gene symbol	ZNF131
Synonyms (NCBI Gene)	ZBTB35pHZ-10
Chromosome	5
Chromosome location	5p12

194

Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046774	hsa-miR-222-3p	CLASH	23622248
MIRT463237	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT463236	hsa-miR-5582-5p	PAR-CLIP	23592263
MIRT463235	hsa-miR-5000-5p	PAR-CLIP	23592263
MIRT463234	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT463233	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT463232	hsa-miR-1253	PAR-CLIP	23592263
MIRT463231	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT463230	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT463229	hsa-miR-3167	PAR-CLIP	23592263
MIRT463228	hsa-miR-876-5p	PAR-CLIP	23592263
MIRT463227	hsa-miR-1290	PAR-CLIP	23592263
MIRT463226	hsa-miR-6772-5p	PAR-CLIP	23592263
MIRT463225	hsa-miR-4455	PAR-CLIP	23592263
MIRT463224	hsa-miR-609	PAR-CLIP	23592263
MIRT463223	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT463222	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT463221	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT463220	hsa-miR-8056	PAR-CLIP	23592263
MIRT463219	hsa-miR-3911	PAR-CLIP	23592263
MIRT463218	hsa-miR-2052	PAR-CLIP	23592263
MIRT463217	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT463216	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT463215	hsa-miR-4752	PAR-CLIP	23592263
MIRT463214	hsa-miR-8055	PAR-CLIP	23592263
MIRT463237	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT463236	hsa-miR-5582-5p	PAR-CLIP	23592263
MIRT463235	hsa-miR-5000-5p	PAR-CLIP	23592263
MIRT463234	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT463233	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT463232	hsa-miR-1253	PAR-CLIP	23592263
MIRT463231	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT463230	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT463229	hsa-miR-3167	PAR-CLIP	23592263
MIRT463228	hsa-miR-876-5p	PAR-CLIP	23592263
MIRT463227	hsa-miR-1290	PAR-CLIP	23592263
MIRT463226	hsa-miR-6772-5p	PAR-CLIP	23592263
MIRT463225	hsa-miR-4455	PAR-CLIP	23592263
MIRT463224	hsa-miR-609	PAR-CLIP	23592263
MIRT463223	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT463222	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT463221	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT463220	hsa-miR-8056	PAR-CLIP	23592263
MIRT463219	hsa-miR-3911	PAR-CLIP	23592263
MIRT463218	hsa-miR-2052	PAR-CLIP	23592263
MIRT463217	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT463216	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT463215	hsa-miR-4752	PAR-CLIP	23592263
MIRT463214	hsa-miR-8055	PAR-CLIP	23592263
MIRT1516334	hsa-miR-1231	CLIP-seq
MIRT1516335	hsa-miR-1258	CLIP-seq
MIRT1516336	hsa-miR-1305	CLIP-seq
MIRT1516337	hsa-miR-133a	CLIP-seq
MIRT1516338	hsa-miR-133b	CLIP-seq
MIRT1516339	hsa-miR-3065-3p	CLIP-seq
MIRT1516340	hsa-miR-4261	CLIP-seq
MIRT1516341	hsa-miR-4278	CLIP-seq
MIRT1516342	hsa-miR-4288	CLIP-seq
MIRT1516343	hsa-miR-4291	CLIP-seq
MIRT1516344	hsa-miR-4436b-5p	CLIP-seq
MIRT1516345	hsa-miR-4496	CLIP-seq
MIRT1516346	hsa-miR-4709-5p	CLIP-seq
MIRT1516347	hsa-miR-4716-3p	CLIP-seq
MIRT1516348	hsa-miR-4723-5p	CLIP-seq
MIRT1516349	hsa-miR-4728-5p	CLIP-seq
MIRT1516350	hsa-miR-4804-3p	CLIP-seq
MIRT1516351	hsa-miR-562	CLIP-seq
MIRT1516352	hsa-miR-632	CLIP-seq
MIRT1516353	hsa-miR-9	CLIP-seq
MIRT1516354	hsa-miR-95	CLIP-seq
MIRT1516334	hsa-miR-1231	CLIP-seq
MIRT1516336	hsa-miR-1305	CLIP-seq
MIRT1516337	hsa-miR-133a	CLIP-seq
MIRT1516338	hsa-miR-133b	CLIP-seq
MIRT1516339	hsa-miR-3065-3p	CLIP-seq
MIRT2155802	hsa-miR-3688-5p	CLIP-seq
MIRT1516340	hsa-miR-4261	CLIP-seq
MIRT2155803	hsa-miR-4277	CLIP-seq
MIRT2155804	hsa-miR-4282	CLIP-seq
MIRT1516342	hsa-miR-4288	CLIP-seq
MIRT1516343	hsa-miR-4291	CLIP-seq
MIRT1516344	hsa-miR-4436b-5p	CLIP-seq
MIRT1516345	hsa-miR-4496	CLIP-seq
MIRT1516346	hsa-miR-4709-5p	CLIP-seq
MIRT1516347	hsa-miR-4716-3p	CLIP-seq
MIRT1516348	hsa-miR-4723-5p	CLIP-seq
MIRT1516349	hsa-miR-4728-5p	CLIP-seq
MIRT1516350	hsa-miR-4804-3p	CLIP-seq
MIRT1516352	hsa-miR-632	CLIP-seq
MIRT1516353	hsa-miR-9	CLIP-seq
MIRT1516354	hsa-miR-95	CLIP-seq
MIRT1516334	hsa-miR-1231	CLIP-seq
MIRT1516335	hsa-miR-1258	CLIP-seq
MIRT1516337	hsa-miR-133a	CLIP-seq
MIRT1516338	hsa-miR-133b	CLIP-seq
MIRT1516339	hsa-miR-3065-3p	CLIP-seq
MIRT2375465	hsa-miR-337-3p	CLIP-seq
MIRT2375466	hsa-miR-3685	CLIP-seq
MIRT2375467	hsa-miR-384	CLIP-seq
MIRT1516340	hsa-miR-4261	CLIP-seq
MIRT2155804	hsa-miR-4282	CLIP-seq
MIRT1516342	hsa-miR-4288	CLIP-seq
MIRT1516343	hsa-miR-4291	CLIP-seq
MIRT2375468	hsa-miR-4312	CLIP-seq
MIRT2375469	hsa-miR-4325	CLIP-seq
MIRT1516344	hsa-miR-4436b-5p	CLIP-seq
MIRT1516345	hsa-miR-4496	CLIP-seq
MIRT2375470	hsa-miR-4511	CLIP-seq
MIRT1516346	hsa-miR-4709-5p	CLIP-seq
MIRT1516350	hsa-miR-4804-3p	CLIP-seq
MIRT2375471	hsa-miR-581	CLIP-seq
MIRT1516352	hsa-miR-632	CLIP-seq
MIRT2375472	hsa-miR-802	CLIP-seq
MIRT1516353	hsa-miR-9	CLIP-seq
MIRT1516334	hsa-miR-1231	CLIP-seq
MIRT1516335	hsa-miR-1258	CLIP-seq
MIRT2667864	hsa-miR-1267	CLIP-seq
MIRT1516337	hsa-miR-133a	CLIP-seq
MIRT1516338	hsa-miR-133b	CLIP-seq
MIRT2667865	hsa-miR-134	CLIP-seq
MIRT2667866	hsa-miR-186	CLIP-seq
MIRT1516339	hsa-miR-3065-3p	CLIP-seq
MIRT2667867	hsa-miR-3118	CLIP-seq
MIRT2667868	hsa-miR-3132	CLIP-seq
MIRT2667869	hsa-miR-3133	CLIP-seq
MIRT2667870	hsa-miR-3164	CLIP-seq
MIRT2667871	hsa-miR-3529	CLIP-seq
MIRT2667872	hsa-miR-3613-3p	CLIP-seq
MIRT2667873	hsa-miR-375	CLIP-seq
MIRT2667874	hsa-miR-379	CLIP-seq
MIRT1516340	hsa-miR-4261	CLIP-seq
MIRT2155803	hsa-miR-4277	CLIP-seq
MIRT1516342	hsa-miR-4288	CLIP-seq
MIRT1516343	hsa-miR-4291	CLIP-seq
MIRT2667875	hsa-miR-4426	CLIP-seq
MIRT1516344	hsa-miR-4436b-5p	CLIP-seq
MIRT2667876	hsa-miR-4477b	CLIP-seq
MIRT1516345	hsa-miR-4496	CLIP-seq
MIRT2667877	hsa-miR-4641	CLIP-seq
MIRT2667878	hsa-miR-4642	CLIP-seq
MIRT2667879	hsa-miR-4647	CLIP-seq
MIRT2667880	hsa-miR-4652-3p	CLIP-seq
MIRT2667881	hsa-miR-4662b	CLIP-seq
MIRT2667882	hsa-miR-4677-3p	CLIP-seq
MIRT2667883	hsa-miR-4679	CLIP-seq
MIRT2667884	hsa-miR-4684-3p	CLIP-seq
MIRT1516346	hsa-miR-4709-5p	CLIP-seq
MIRT2667885	hsa-miR-4744	CLIP-seq
MIRT1516350	hsa-miR-4804-3p	CLIP-seq
MIRT2667886	hsa-miR-513a-3p	CLIP-seq
MIRT2667887	hsa-miR-518a-5p	CLIP-seq
MIRT2667888	hsa-miR-527	CLIP-seq
MIRT2667889	hsa-miR-548ac	CLIP-seq
MIRT2667890	hsa-miR-548d-3p	CLIP-seq
MIRT2667891	hsa-miR-548z	CLIP-seq
MIRT1516352	hsa-miR-632	CLIP-seq
MIRT1516353	hsa-miR-9	CLIP-seq
MIRT1516334	hsa-miR-1231	CLIP-seq
MIRT1516335	hsa-miR-1258	CLIP-seq
MIRT2667864	hsa-miR-1267	CLIP-seq
MIRT1516337	hsa-miR-133a	CLIP-seq
MIRT1516338	hsa-miR-133b	CLIP-seq
MIRT2667865	hsa-miR-134	CLIP-seq
MIRT2667866	hsa-miR-186	CLIP-seq
MIRT1516339	hsa-miR-3065-3p	CLIP-seq
MIRT2667867	hsa-miR-3118	CLIP-seq
MIRT2667868	hsa-miR-3132	CLIP-seq
MIRT2667869	hsa-miR-3133	CLIP-seq
MIRT2667870	hsa-miR-3164	CLIP-seq
MIRT2667871	hsa-miR-3529	CLIP-seq
MIRT2667874	hsa-miR-379	CLIP-seq
MIRT1516340	hsa-miR-4261	CLIP-seq
MIRT1516342	hsa-miR-4288	CLIP-seq
MIRT1516343	hsa-miR-4291	CLIP-seq
MIRT2667875	hsa-miR-4426	CLIP-seq
MIRT1516344	hsa-miR-4436b-5p	CLIP-seq
MIRT2667876	hsa-miR-4477b	CLIP-seq
MIRT1516345	hsa-miR-4496	CLIP-seq
MIRT2667877	hsa-miR-4641	CLIP-seq
MIRT2667878	hsa-miR-4642	CLIP-seq
MIRT2667879	hsa-miR-4647	CLIP-seq
MIRT2667880	hsa-miR-4652-3p	CLIP-seq
MIRT2667881	hsa-miR-4662b	CLIP-seq
MIRT2667882	hsa-miR-4677-3p	CLIP-seq
MIRT2667883	hsa-miR-4679	CLIP-seq
MIRT2667884	hsa-miR-4684-3p	CLIP-seq
MIRT1516346	hsa-miR-4709-5p	CLIP-seq
MIRT2695735	hsa-miR-4715-3p	CLIP-seq
MIRT2667885	hsa-miR-4744	CLIP-seq
MIRT1516350	hsa-miR-4804-3p	CLIP-seq
MIRT2667887	hsa-miR-518a-5p	CLIP-seq
MIRT2667888	hsa-miR-527	CLIP-seq
MIRT1516352	hsa-miR-632	CLIP-seq
MIRT1516353	hsa-miR-9	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0002682	Process	Regulation of immune system process	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
604073	12915	ENSG00000172262

P52739

Protein name

Zinc finger protein 131

Protein function

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	24 → 129	BTB/POZ domain	Domain
PF12874	zf-met	288 → 308		Domain
PF12874	zf-met	392 → 415		Domain

Tissue specificity

TISSUE SPECIFICITY: Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus. {ECO:0000269|PubMed:12163020}.

Sequence

MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFY
KFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKA
LEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVE
DEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPT
SKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRE
SAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFECPN
CHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPN
HCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHV
LPLLQVQVDSAQVTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHV
EELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLET
KPTVDSEAEKAENEDRTALPVLE

Sequence length

623

Interactions

View interactions

	Reactome
			SUMOylation of transcription cofactors

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Agenesis of Cerebellar Vermis	Associate	28596487	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Associate	28596487	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ciliopathies	Associate	28596487	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	28596487	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	28596487	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF131 (zinc finger protein 131)