Gene Gene information from NCBI Gene database.
Entrez ID 7644
Gene name Zinc finger protein 91
Gene symbol ZNF91
Synonyms (NCBI Gene)
HPF7HTF10
Chromosome 19
Chromosome location 19p12
Summary The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
miRNA miRNA information provided by mirtarbase database.
651
miRTarBase ID miRNA Experiments Reference
MIRT633808 hsa-miR-6819-3p HITS-CLIP 23824327
MIRT633807 hsa-miR-6877-3p HITS-CLIP 23824327
MIRT633806 hsa-miR-4722-3p HITS-CLIP 23824327
MIRT633805 hsa-miR-6727-3p HITS-CLIP 23824327
MIRT633804 hsa-miR-6747-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 25274305
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
GO:0003677 Function DNA binding IEA
GO:0003700 Function DNA-binding transcription factor activity NAS 2023909
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603971 13166 ENSG00000167232
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q05481
Protein name Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10)
Protein function Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also b
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 12 53 KRAB box Family
PF00096 zf-C2H2 238 259 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 294 316 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 322 344 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 350 372 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 378 400 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 406 428 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 434 456 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 462 484 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 490 512 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 546 568 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 574 596 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 630 652 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 658 680 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 686 708 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 714 736 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 742 764 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 770 792 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 798 820 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 826 848 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 854 876 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 910 932 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 938 960 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 966 988 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 994 1016 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1022 1044 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1050 1072 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1078 1100 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1106 1128 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1134 1156 Zinc finger, C2H2 type Domain
Sequence
MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPD
LITYLEQGKEPWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENL
QLRKGCKSVDECKVHKEGYNKLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKK
CFKCKKCVKSFCIRLHKTQHKCVYITEKSCKCKECEKTFHWSSTLTNHKEIHTEDKPYKC
EECGKAFKQLSTLTTHKII
CAKEKIYKCEECGKAFLWSSTLTRHKRIHTGEKPYKCEECG
KAFSHSSTLAKHKRIH
TGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFS
NSSTLANHKITH
TEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSN
LTIHKFIH
TGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRH
KRIH
TGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIH
SREKPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEK
SYKCEECGKAFLWSSTLRRHKRIHTGEKPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC
KECGKAFSNSSTLANHKITH
TEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECG
KAFNRSSNLTIHKFIH
TGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFI
WSSTLTRHKRIH
TGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSA
LAKHKIIH
AGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEH
KRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIH
TGEKPYKCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEK
PYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHKRIHTREKPYKC
EECGKAFSQSSTLTRHKRLH
TGEKPYKCGECGKAFKESSALTKHKIIHTGEKPYKCEKCG
KAFNQSSILTNHKKIH
TITPVIPLLWEAEAGGSRGQEMETILANTVKPLLY
Sequence length 1191
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Cataract Uncertain significance ClinVar
Disgenet
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
CENTRAL NERVOUS SYSTEM ORIGIN VERTIGO GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Congenital nephrotic syndrome Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Colorectal Neoplasms Associate 35487942
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Associate 37013470
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 36375317
★☆☆☆☆
Found in Text Mining only
Vertigo Associate 39174713
★☆☆☆☆
Found in Text Mining only