Gene Gene information from NCBI Gene database.
Entrez ID 7639
Gene name Zinc finger protein 85
Gene symbol ZNF85
Synonyms (NCBI Gene)
HPF4HTF1
Chromosome 19
Chromosome location 19p12
miRNA miRNA information provided by mirtarbase database.
404
miRTarBase ID miRNA Experiments Reference
MIRT024843 hsa-miR-215-5p Microarray 19074876
MIRT026711 hsa-miR-192-5p Microarray 19074876
MIRT029822 hsa-miR-26b-5p Microarray 19088304
MIRT718436 hsa-miR-3064-5p HITS-CLIP 19536157
MIRT718435 hsa-miR-6504-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 9839802
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 9839802
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603899 13160 ENSG00000105750
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q03923
Protein name Zinc finger protein 85 (Zinc finger protein HPF4) (Zinc finger protein HTF1)
Protein function May be a transcriptional repressor.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 3 44 KRAB box Family
PF13912 zf-C2H2_6 174 199 Domain
PF00096 zf-C2H2 202 224 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 230 252 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 258 280 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 286 308 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 314 336 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 342 364 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 370 392 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 398 420 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 426 448 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 454 476 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 482 504 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 510 532 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 538 560 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, including in testis. {ECO:0000269|PubMed:2023909, ECO:0000269|PubMed:9839802}.
Sequence
Sequence length 595
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEARING LOSS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations