Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7638
Gene name	Zinc finger protein 221
Gene symbol	ZNF221
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.31

Show/Hide all (62)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017933	hsa-miR-335-5p	Microarray	18185580
MIRT1518487	hsa-miR-1262	CLIP-seq
MIRT1518488	hsa-miR-1827	CLIP-seq
MIRT1518489	hsa-miR-1972	CLIP-seq
MIRT1518490	hsa-miR-3160-3p	CLIP-seq
MIRT1518491	hsa-miR-3192	CLIP-seq
MIRT1518492	hsa-miR-3672	CLIP-seq
MIRT1518493	hsa-miR-3689a-3p	CLIP-seq
MIRT1518494	hsa-miR-3689c	CLIP-seq
MIRT1518495	hsa-miR-3929	CLIP-seq
MIRT1518496	hsa-miR-4327	CLIP-seq
MIRT1518497	hsa-miR-4419b	CLIP-seq
MIRT1518498	hsa-miR-4478	CLIP-seq
MIRT1518499	hsa-miR-4487	CLIP-seq
MIRT1518500	hsa-miR-4649-3p	CLIP-seq
MIRT1518501	hsa-miR-4650-5p	CLIP-seq
MIRT1518502	hsa-miR-4701-3p	CLIP-seq
MIRT1518503	hsa-miR-4722-5p	CLIP-seq
MIRT1518504	hsa-miR-4728-5p	CLIP-seq
MIRT1518505	hsa-miR-4768-3p	CLIP-seq
MIRT1518506	hsa-miR-490-3p	CLIP-seq
MIRT1518507	hsa-miR-558	CLIP-seq
MIRT1518508	hsa-miR-661	CLIP-seq
MIRT1518509	hsa-miR-940	CLIP-seq
MIRT1518487	hsa-miR-1262	CLIP-seq
MIRT1518488	hsa-miR-1827	CLIP-seq
MIRT1518490	hsa-miR-3160-3p	CLIP-seq
MIRT1518491	hsa-miR-3192	CLIP-seq
MIRT1518493	hsa-miR-3689a-3p	CLIP-seq
MIRT1518494	hsa-miR-3689c	CLIP-seq
MIRT1518495	hsa-miR-3929	CLIP-seq
MIRT1518496	hsa-miR-4327	CLIP-seq
MIRT1518497	hsa-miR-4419b	CLIP-seq
MIRT1518498	hsa-miR-4478	CLIP-seq
MIRT1518499	hsa-miR-4487	CLIP-seq
MIRT1518500	hsa-miR-4649-3p	CLIP-seq
MIRT1518502	hsa-miR-4701-3p	CLIP-seq
MIRT1518503	hsa-miR-4722-5p	CLIP-seq
MIRT1518504	hsa-miR-4728-5p	CLIP-seq
MIRT1518505	hsa-miR-4768-3p	CLIP-seq
MIRT1518506	hsa-miR-490-3p	CLIP-seq
MIRT1518507	hsa-miR-558	CLIP-seq
MIRT1518509	hsa-miR-940	CLIP-seq
MIRT1518490	hsa-miR-3160-3p	CLIP-seq
MIRT1518491	hsa-miR-3192	CLIP-seq
MIRT1518493	hsa-miR-3689a-3p	CLIP-seq
MIRT1518494	hsa-miR-3689c	CLIP-seq
MIRT1518496	hsa-miR-4327	CLIP-seq
MIRT1518499	hsa-miR-4487	CLIP-seq
MIRT1518503	hsa-miR-4722-5p	CLIP-seq
MIRT1518504	hsa-miR-4728-5p	CLIP-seq
MIRT1518505	hsa-miR-4768-3p	CLIP-seq
MIRT1518506	hsa-miR-490-3p	CLIP-seq
MIRT1518507	hsa-miR-558	CLIP-seq
MIRT1518509	hsa-miR-940	CLIP-seq
MIRT2464095	hsa-miR-3120-5p	CLIP-seq
MIRT2464096	hsa-miR-3613-3p	CLIP-seq
MIRT2464097	hsa-miR-3664-5p	CLIP-seq
MIRT1518492	hsa-miR-3672	CLIP-seq
MIRT2464098	hsa-miR-371-5p	CLIP-seq
MIRT2464099	hsa-miR-371b-5p	CLIP-seq
MIRT2464100	hsa-miR-4522	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9UK13

Protein name

Zinc finger protein 221

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	29 → 70	KRAB box	Family
PF00096	zf-C2H2	198 → 220	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	226 → 248	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	282 → 304	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	310 → 332	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	338 → 360	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	422 → 444	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	478 → 500	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	506 → 528	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	534 → 556	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	562 → 584	Zinc finger, C2H2 type	Domain

Sequence

MISPSLELLHSGLCKFPEVEGKMTTFKEAVTFKDVAVVFTEEELGLLDPAQRKLYRDVML
ENFRNLLSVGNQPFHQDTFHFLGKEKFWKMKTTSQREGNSGGKIQIEMETVPEAGPHEEW
SCQQIWEQIASDLTRSQNSIRNSSQFFKEGDVPCQIEARLSISHVQQKPYRCNECKQSFS
DVSVFDLHQQSHSGEKSHTCGECGKSFCYSPALHIHQRVHMGEKCYKCDVCGKEFNQSSH
LQTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYNCEECGKAFIHDSQLQEH
QRIHTGEKPFKCDICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVH
IEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQVHSGQK
SFKCEECGKGFYTNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVHTGERPYNC
KECGKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQSSQLHSHQTCHTGEKLYKCEQCE
KGYNSKFNLDMHQRVHGGERPYNCKECGKSFGWASCLLKHQRLHSGEKPLKSGVWEEIYS
EFTASFTSVSLCGRKAI

Sequence length

617

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CEREBRAL ATHEROSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF221 (zinc finger protein 221)