Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7597
Gene name	Zinc finger and BTB domain containing 25
Gene symbol	ZBTB25
Synonyms (NCBI Gene)	C14orf51KUPZNF46
Chromosome	14
Chromosome location	14q23.3

114

Show/Hide all (114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028786	hsa-miR-26b-5p	Microarray	19088304
MIRT715663	hsa-miR-4694-3p	HITS-CLIP	19536157
MIRT715662	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT715661	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT715660	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT715659	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT715658	hsa-miR-4261	HITS-CLIP	19536157
MIRT715657	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT689131	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT689130	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT689129	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT689128	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT689127	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT689126	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT689125	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT689124	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT689123	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT689122	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT689121	hsa-miR-520h	HITS-CLIP	23313552
MIRT689120	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT689119	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT689118	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT689117	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT689116	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT689115	hsa-miR-4750-3p	HITS-CLIP	23313552
MIRT689114	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT689113	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT689112	hsa-miR-6790-3p	HITS-CLIP	23313552
MIRT689111	hsa-miR-6821-3p	HITS-CLIP	23313552
MIRT689110	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT689109	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT689108	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT689107	hsa-miR-7973	HITS-CLIP	23313552
MIRT689106	hsa-miR-4256	HITS-CLIP	23313552
MIRT689105	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT689104	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT689103	hsa-miR-100-3p	HITS-CLIP	23313552
MIRT689102	hsa-miR-4453	HITS-CLIP	23313552
MIRT689101	hsa-miR-4538	HITS-CLIP	23313552
MIRT689100	hsa-miR-4528	HITS-CLIP	23313552
MIRT689099	hsa-miR-145-5p	HITS-CLIP	23313552
MIRT689098	hsa-miR-5195-3p	HITS-CLIP	23313552
MIRT689097	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT689096	hsa-miR-498	HITS-CLIP	23313552
MIRT689095	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT642167	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642166	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642165	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT642164	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642163	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT568668	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT568667	hsa-miR-1915-3p	PAR-CLIP	20371350
MIRT568666	hsa-miR-6764-5p	PAR-CLIP	20371350
MIRT568665	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT568664	hsa-miR-138-2-3p	PAR-CLIP	20371350
MIRT568663	hsa-miR-4804-3p	PAR-CLIP	20371350
MIRT568662	hsa-miR-7977	PAR-CLIP	20371350
MIRT715663	hsa-miR-4694-3p	HITS-CLIP	19536157
MIRT715662	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT715661	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT715660	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT715659	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT715658	hsa-miR-4261	HITS-CLIP	19536157
MIRT715657	hsa-miR-526b-5p	HITS-CLIP	19536157
MIRT689131	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT689130	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT689129	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT689128	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT689127	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT689126	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT689125	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT689124	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT689123	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT689122	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT689121	hsa-miR-520h	HITS-CLIP	23313552
MIRT689120	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT689119	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT689118	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT689117	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT689116	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT689115	hsa-miR-4750-3p	HITS-CLIP	23313552
MIRT689114	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT689113	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT689112	hsa-miR-6790-3p	HITS-CLIP	23313552
MIRT689111	hsa-miR-6821-3p	HITS-CLIP	23313552
MIRT689110	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT689109	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT689108	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT689107	hsa-miR-7973	HITS-CLIP	23313552
MIRT689106	hsa-miR-4256	HITS-CLIP	23313552
MIRT689105	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT689104	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT689103	hsa-miR-100-3p	HITS-CLIP	23313552
MIRT689102	hsa-miR-4453	HITS-CLIP	23313552
MIRT689101	hsa-miR-4538	HITS-CLIP	23313552
MIRT689100	hsa-miR-4528	HITS-CLIP	23313552
MIRT689099	hsa-miR-145-5p	HITS-CLIP	23313552
MIRT689098	hsa-miR-5195-3p	HITS-CLIP	23313552
MIRT689097	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT689096	hsa-miR-498	HITS-CLIP	23313552
MIRT689095	hsa-miR-3180-5p	HITS-CLIP	23313552
MIRT642167	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642166	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642165	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT642164	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642163	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT568668	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT568667	hsa-miR-1915-3p	PAR-CLIP	20371350
MIRT568666	hsa-miR-6764-5p	PAR-CLIP	20371350
MIRT568665	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT568664	hsa-miR-138-2-3p	PAR-CLIP	20371350
MIRT568663	hsa-miR-4804-3p	PAR-CLIP	20371350
MIRT568662	hsa-miR-7977	PAR-CLIP	20371350
MIRT1502260	hsa-miR-3942-3p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0002682	Process	Regulation of immune system process	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	2027750
GO:0005515	Function	Protein binding	IPI	16189514, 20211142, 21516116, 25416956, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
194541	13112	ENSG00000089775

P24278

Protein name

Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	14 → 118	BTB/POZ domain	Domain
PF00096	zf-C2H2	238 → 260	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	349 → 371	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed mainly in hematopoietic cells and testis.

Sequence

MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSEC
IKIQPTDIQPDIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSP
ETVQSSNLYGIQISTTQKTVVKQGLEVKEAPSSNSGNRAAVQGDHPQLQLSLAIGLDDGT
ADQQRACPATQALEEHQKPPVSIKQERCDPESVISQSHPSPSSEVTGPTFTENSVKIHLC
HYCGERFDSRSNLRQHLHTHVSGSLPFGVPASILESNDLGEVHPLNENSEALECRRLSSF
IVKENEQQPDHTNRGTTEPLQISQVSLISKDTEPVELNCNFSFSRKRKMSCTICGHKFPR
KSQLLEHMYTHKGKSYRYNRCQRFGNALAQRFQPYCDSWSDVSLKSSRLSQEHLDLPCAL
ESELTQENVDTILVE

Sequence length

435

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED IMMUNODEFICIENCY AND MEGALOBLASTIC ANEMIA WITH OR WITHOUT HYPERHOMOCYSTEINEMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURAL TUBE DEFECT, FOLATE-SENSITIVE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE COMBINED IMMUNODEFICIENCY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ZBTB25-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Coronavirus Infections	Associate	37890782	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZBTB25 (zinc finger and BTB domain containing 25)