Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7594
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger protein 43
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZNF43
Synonyms (NCBI Gene) Gene synonyms aliases
HTF6, KOX27, ZNF39L1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT661148 hsa-miR-34b-3p HITS-CLIP 23824327
MIRT661147 hsa-miR-4655-5p HITS-CLIP 23824327
MIRT661146 hsa-miR-6808-5p HITS-CLIP 23824327
MIRT661145 hsa-miR-6893-5p HITS-CLIP 23824327
MIRT661144 hsa-miR-940 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding TAS 1711675
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0006355 Process Regulation of DNA-templated transcription IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603972 13109 ENSG00000198521
Protein
UniProt ID P17038
Protein name Zinc finger protein 43 (Zinc finger protein 39) (Zinc finger protein HTF6) (Zinc finger protein KOX27)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 3 44 KRAB box Family
PF00096 zf-C2H2 174 196 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 286 308 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 314 336 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 342 364 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 370 392 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 398 420 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 426 448 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 454 476 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 482 504 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 510 532 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 538 560 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 566 588 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 594 616 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 622 644 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 650 672 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 678 700 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 706 728 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 734 756 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 762 784 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: T- and B-cell lines.
Sequence
MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEK
EPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKS
VDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSNSNRHKISHTEKKLFKCKECG
KSFCMLPHLAQHKIIH
TRVNFCKCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFN
WSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSN
LTEHKKIH
PGEKPYKCEECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTH
KRIH
TAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTH
TGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIHTAEK
PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKC
EECGKAFNHFSILTKHKRIH
TGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECG
KAFTQSSNLTTHKKIH
TGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFK
WSSTLTKHKIIH
TGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSN
LIEHKKIH
TGEQPYKCEECGKAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTH
NKIH
TGEKLYKPEDVTVILTTPQTFSNIK
Sequence length 809
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Uterine Fibroids Uterine fibroids N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 30999858, 36142151
Neoplasms Associate 30999858
Neoplasms Inhibit 36142151
Squamous Cell Carcinoma of Head and Neck Associate 35794182
Tarlov Cysts Associate 38287071