MZF1 (myeloid zinc finger 1)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein
Entrez ID 7593
Gene name Myeloid zinc finger 1
Gene symbol MZF1
Synonyms (NCBI Gene)
MZF-1MZF1BZFP98ZNF42ZSCAN6
Chromosome 19
Chromosome location 19q13.43
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene Transcription factors Gene ontology Other IDs Protein
Show/Hide all (1)
Transcription factor Regulation Reference
MYB Unknown 7565760
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
Gene Transcription factors Gene ontology Other IDs Protein
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 7579328
GO:0000976 Function Transcription cis-regulatory region binding IDA 15541732
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7579328
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
194550 13108 ENSG00000099326
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P28698
Protein name Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42)
Protein function Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0
PDB 2FI2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02023 SCAN 40 → 129 SCAN domain Domain
PF00096 zf-C2H2 357 → 378 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 384 → 406 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 412 → 434 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 440 → 462 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 541 → 563 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 569 → 591 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 597 → 619 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 625 → 647 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 653 → 675 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 681 → 703 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 709 → 731 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts. {ECO:0000269|PubMed:15541732}.
Sequence 
MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQE
ALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVD
GLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLG
LQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWR
EHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGG
FAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDV
CGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQG
FVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPE
PPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERP
FACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACP
ECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQ
SFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQ
STKLIQHQRVHSAE
Sequence length 734
Interactions View interactions