ZNF18 (zinc finger protein 18)

Gene

• Entrez ID: 7566
• Gene name: Zinc finger protein 18
• Gene symbol: ZNF18
• Synonyms (NCBI Gene): HDSG1, KOX11, ZKSCAN6, ZNF535, ZSCAN38, Zfp535
• Chromosome: 17
• Chromosome location: 17p12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1517248	hsa-miR-2110	CLIP-seq
MIRT1517249	hsa-miR-3153	CLIP-seq
MIRT1517250	hsa-miR-3183	CLIP-seq
MIRT1517251	hsa-miR-4271	CLIP-seq
MIRT1517252	hsa-miR-4279	CLIP-seq
MIRT1517253	hsa-miR-4311	CLIP-seq
MIRT1517254	hsa-miR-4723-3p	CLIP-seq
MIRT1517255	hsa-miR-4725-3p	CLIP-seq
MIRT1517256	hsa-miR-515-5p	CLIP-seq
MIRT2375724	hsa-miR-134	CLIP-seq
MIRT2375725	hsa-miR-1587	CLIP-seq
MIRT2375726	hsa-miR-2113	CLIP-seq
MIRT2375727	hsa-miR-3118	CLIP-seq
MIRT2375728	hsa-miR-3160-3p	CLIP-seq
MIRT2375729	hsa-miR-3164	CLIP-seq
MIRT2375730	hsa-miR-3192	CLIP-seq
MIRT2375731	hsa-miR-378g	CLIP-seq
MIRT2375732	hsa-miR-4492	CLIP-seq
MIRT2375733	hsa-miR-4498	CLIP-seq
MIRT2375734	hsa-miR-4505	CLIP-seq
MIRT2375735	hsa-miR-4534	CLIP-seq
MIRT2375736	hsa-miR-4633-3p	CLIP-seq
MIRT2375737	hsa-miR-4656	CLIP-seq
MIRT2375738	hsa-miR-4675	CLIP-seq
MIRT2375739	hsa-miR-4691-5p	CLIP-seq
MIRT2375740	hsa-miR-4741	CLIP-seq
MIRT2375741	hsa-miR-496	CLIP-seq
MIRT2375742	hsa-miR-758	CLIP-seq
MIRT2375743	hsa-miR-762	CLIP-seq
MIRT2464069	hsa-miR-3200-5p	CLIP-seq
MIRT2464070	hsa-miR-4649-3p	CLIP-seq
MIRT2375737	hsa-miR-4656	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 194524
• HGNC: 12969
• e!Ensembl: ENSG00000154957

Protein

• UniProt ID: P17022
• Protein name: Zinc finger protein 18 (Heart development-specific gene 1 protein) (Zinc finger protein 535) (Zinc finger protein KOX11) (Zinc finger protein with KRAB and SCAN domains 6)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02023	SCAN	37 → 125	SCAN domain	Domain
  PF01352	KRAB	221 → 250	KRAB box	Family
  PF00096	zf-C2H2	409 → 430	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	436 → 458	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	464 → 486	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	492 → 514	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	520 → 542	Zinc finger, C2H2 type	Domain

• Sequence:

  MPVDLGQALGLLPSLAKAEDSQFSESDAALQEELSSPETARQLFRQFRYQVMSGPHETLK
  QLRKLCFQWLQPEVHTKEQILEILMLEQFLTILPGEIQMWVRKQCPGSGEEAVTLVESLK
  GDPQRLWQWISIQVLGQDILSEKMESPSCQVGEVEPHLEVVPQELGLENSSSGPGELLSH
  IVKEESDTEAELALAASQPARLEERLIRDQDLGASLLPAAPQEQWRQLDSTQKEQYWDLM
  LETYGKMVSGAGISHPKSDLTNSIEFGEELAGIYLHVNEKIPRPTCIGDRQENDKENLNL
  ENHRDQELLHASCQASGEVPSQASLRGFFTEDEPGCFGEGENLPEALQNIQDEGTGEQLS
  PQERISEKQLGQHLPNPHSGEMSTMWLEEKRETSQKGQPRAPMAQKLPTCRECGKTFYRN
  SQLIFHQRTHTGETYFQCTICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGFSDFSGLR
  HHEKIHTGEKPYKCPICEKSFIQRSNFNRHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQR
  SHLGKKPFQ

• Sequence length: 549

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Autistic Disorder	Associate	22511880	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	35954157	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35954157	★☆☆☆☆ Found in Text Mining only