Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7561
Gene name	Zinc finger protein 14
Gene symbol	ZNF14
Synonyms (NCBI Gene)	GIOT-4KOX6
Chromosome	19
Chromosome location	19p13.11
Summary	The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

153

Show/Hide all (153)

miRTarBase ID	miRNA	Experiments
MIRT1516593	hsa-miR-1	CLIP-seq
MIRT1516594	hsa-miR-103a	CLIP-seq
MIRT1516595	hsa-miR-107	CLIP-seq
MIRT1516596	hsa-miR-1184	CLIP-seq
MIRT1516597	hsa-miR-1226	CLIP-seq
MIRT1516598	hsa-miR-1229	CLIP-seq
MIRT1516599	hsa-miR-181a	CLIP-seq
MIRT1516600	hsa-miR-181b	CLIP-seq
MIRT1516601	hsa-miR-181c	CLIP-seq
MIRT1516602	hsa-miR-181d	CLIP-seq
MIRT1516603	hsa-miR-203	CLIP-seq
MIRT1516604	hsa-miR-206	CLIP-seq
MIRT1516605	hsa-miR-3646	CLIP-seq
MIRT1516606	hsa-miR-3647-3p	CLIP-seq
MIRT1516607	hsa-miR-3652	CLIP-seq
MIRT1516608	hsa-miR-3673	CLIP-seq
MIRT1516609	hsa-miR-371b-5p	CLIP-seq
MIRT1516610	hsa-miR-4262	CLIP-seq
MIRT1516611	hsa-miR-4418	CLIP-seq
MIRT1516612	hsa-miR-4420	CLIP-seq
MIRT1516613	hsa-miR-4421	CLIP-seq
MIRT1516614	hsa-miR-4430	CLIP-seq
MIRT1516615	hsa-miR-4438	CLIP-seq
MIRT1516616	hsa-miR-4477a	CLIP-seq
MIRT1516617	hsa-miR-4493	CLIP-seq
MIRT1516618	hsa-miR-452	CLIP-seq
MIRT1516619	hsa-miR-4676-3p	CLIP-seq
MIRT1516620	hsa-miR-4695-3p	CLIP-seq
MIRT1516621	hsa-miR-4733-3p	CLIP-seq
MIRT1516622	hsa-miR-485-3p	CLIP-seq
MIRT1516623	hsa-miR-509-3-5p	CLIP-seq
MIRT1516624	hsa-miR-509-5p	CLIP-seq
MIRT1516625	hsa-miR-511	CLIP-seq
MIRT1516626	hsa-miR-517a	CLIP-seq
MIRT1516627	hsa-miR-517c	CLIP-seq
MIRT1516628	hsa-miR-613	CLIP-seq
MIRT1516593	hsa-miR-1	CLIP-seq
MIRT1516599	hsa-miR-181a	CLIP-seq
MIRT1516600	hsa-miR-181b	CLIP-seq
MIRT1516601	hsa-miR-181c	CLIP-seq
MIRT1516602	hsa-miR-181d	CLIP-seq
MIRT1516604	hsa-miR-206	CLIP-seq
MIRT2155923	hsa-miR-296-3p	CLIP-seq
MIRT2155924	hsa-miR-3120-5p	CLIP-seq
MIRT1516607	hsa-miR-3652	CLIP-seq
MIRT1516608	hsa-miR-3673	CLIP-seq
MIRT2155925	hsa-miR-377	CLIP-seq
MIRT2155926	hsa-miR-3925-3p	CLIP-seq
MIRT1516610	hsa-miR-4262	CLIP-seq
MIRT1516614	hsa-miR-4430	CLIP-seq
MIRT1516615	hsa-miR-4438	CLIP-seq
MIRT1516620	hsa-miR-4695-3p	CLIP-seq
MIRT2155927	hsa-miR-4712-5p	CLIP-seq
MIRT2155928	hsa-miR-4768-5p	CLIP-seq
MIRT2155929	hsa-miR-4772-3p	CLIP-seq
MIRT1516628	hsa-miR-613	CLIP-seq
MIRT2155930	hsa-miR-630	CLIP-seq
MIRT2155931	hsa-miR-708	CLIP-seq
MIRT2155932	hsa-miR-766	CLIP-seq
MIRT2155933	hsa-miR-770-5p	CLIP-seq
MIRT1516593	hsa-miR-1	CLIP-seq
MIRT2375582	hsa-miR-1200	CLIP-seq
MIRT2375583	hsa-miR-1297	CLIP-seq
MIRT1516599	hsa-miR-181a	CLIP-seq
MIRT1516600	hsa-miR-181b	CLIP-seq
MIRT1516601	hsa-miR-181c	CLIP-seq
MIRT1516602	hsa-miR-181d	CLIP-seq
MIRT2375584	hsa-miR-1976	CLIP-seq
MIRT1516604	hsa-miR-206	CLIP-seq
MIRT2375585	hsa-miR-26a	CLIP-seq
MIRT2375586	hsa-miR-26b	CLIP-seq
MIRT2155923	hsa-miR-296-3p	CLIP-seq
MIRT2155924	hsa-miR-3120-5p	CLIP-seq
MIRT2375587	hsa-miR-34b	CLIP-seq
MIRT1516607	hsa-miR-3652	CLIP-seq
MIRT1516608	hsa-miR-3673	CLIP-seq
MIRT2155926	hsa-miR-3925-3p	CLIP-seq
MIRT1516610	hsa-miR-4262	CLIP-seq
MIRT2375588	hsa-miR-4279	CLIP-seq
MIRT2375589	hsa-miR-4324	CLIP-seq
MIRT1516614	hsa-miR-4430	CLIP-seq
MIRT1516615	hsa-miR-4438	CLIP-seq
MIRT2375590	hsa-miR-4465	CLIP-seq
MIRT1516618	hsa-miR-452	CLIP-seq
MIRT1516619	hsa-miR-4676-3p	CLIP-seq
MIRT1516620	hsa-miR-4695-3p	CLIP-seq
MIRT2155927	hsa-miR-4712-5p	CLIP-seq
MIRT2375591	hsa-miR-4722-3p	CLIP-seq
MIRT2155928	hsa-miR-4768-5p	CLIP-seq
MIRT1516622	hsa-miR-485-3p	CLIP-seq
MIRT2375592	hsa-miR-544b	CLIP-seq
MIRT1516628	hsa-miR-613	CLIP-seq
MIRT2155930	hsa-miR-630	CLIP-seq
MIRT2155931	hsa-miR-708	CLIP-seq
MIRT2155932	hsa-miR-766	CLIP-seq
MIRT2155933	hsa-miR-770-5p	CLIP-seq
MIRT2375593	hsa-miR-877	CLIP-seq
MIRT2375594	hsa-miR-889	CLIP-seq
MIRT2155926	hsa-miR-3925-3p	CLIP-seq
MIRT2155932	hsa-miR-766	CLIP-seq
MIRT1516593	hsa-miR-1	CLIP-seq
MIRT2667917	hsa-miR-1260	CLIP-seq
MIRT2667918	hsa-miR-1260b	CLIP-seq
MIRT2375583	hsa-miR-1297	CLIP-seq
MIRT2667919	hsa-miR-188-3p	CLIP-seq
MIRT1516604	hsa-miR-206	CLIP-seq
MIRT2375585	hsa-miR-26a	CLIP-seq
MIRT2375586	hsa-miR-26b	CLIP-seq
MIRT2155924	hsa-miR-3120-5p	CLIP-seq
MIRT2667920	hsa-miR-3125	CLIP-seq
MIRT2667921	hsa-miR-3156-3p	CLIP-seq
MIRT1516607	hsa-miR-3652	CLIP-seq
MIRT2667922	hsa-miR-3672	CLIP-seq
MIRT1516608	hsa-miR-3673	CLIP-seq
MIRT2155925	hsa-miR-377	CLIP-seq
MIRT2667923	hsa-miR-3916	CLIP-seq
MIRT2155926	hsa-miR-3925-3p	CLIP-seq
MIRT2375588	hsa-miR-4279	CLIP-seq
MIRT2667924	hsa-miR-4301	CLIP-seq
MIRT1516614	hsa-miR-4430	CLIP-seq
MIRT1516615	hsa-miR-4438	CLIP-seq
MIRT2667925	hsa-miR-4446-5p	CLIP-seq
MIRT2375590	hsa-miR-4465	CLIP-seq
MIRT1516620	hsa-miR-4695-3p	CLIP-seq
MIRT2667926	hsa-miR-4699-5p	CLIP-seq
MIRT2667927	hsa-miR-4778-5p	CLIP-seq
MIRT2667928	hsa-miR-518d-5p	CLIP-seq
MIRT2667929	hsa-miR-519b-5p	CLIP-seq
MIRT2667930	hsa-miR-519c-5p	CLIP-seq
MIRT2667931	hsa-miR-520c-5p	CLIP-seq
MIRT2667932	hsa-miR-526a	CLIP-seq
MIRT2667933	hsa-miR-526b	CLIP-seq
MIRT2667934	hsa-miR-578	CLIP-seq
MIRT1516628	hsa-miR-613	CLIP-seq
MIRT2667935	hsa-miR-7	CLIP-seq
MIRT2155932	hsa-miR-766	CLIP-seq
MIRT2375593	hsa-miR-877	CLIP-seq
MIRT2375583	hsa-miR-1297	CLIP-seq
MIRT2375585	hsa-miR-26a	CLIP-seq
MIRT2375586	hsa-miR-26b	CLIP-seq
MIRT2155924	hsa-miR-3120-5p	CLIP-seq
MIRT2667920	hsa-miR-3125	CLIP-seq
MIRT2155925	hsa-miR-377	CLIP-seq
MIRT2667923	hsa-miR-3916	CLIP-seq
MIRT2155926	hsa-miR-3925-3p	CLIP-seq
MIRT2375590	hsa-miR-4465	CLIP-seq
MIRT2667928	hsa-miR-518d-5p	CLIP-seq
MIRT2667929	hsa-miR-519b-5p	CLIP-seq
MIRT2667930	hsa-miR-519c-5p	CLIP-seq
MIRT2667931	hsa-miR-520c-5p	CLIP-seq
MIRT2667932	hsa-miR-526a	CLIP-seq
MIRT2155932	hsa-miR-766	CLIP-seq
MIRT2375593	hsa-miR-877	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
194556	12924	ENSG00000105708

P17017

Protein name

Zinc finger protein 14 (Gonadotropin-inducible ovary transcription repressor 4) (GIOT-4) (Zinc finger protein KOX6)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	3 → 44	KRAB box	Family
PF00096	zf-C2H2	103 → 125	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	169 → 194		Domain
PF13912	zf-C2H2_6	197 → 216		Domain
PF13912	zf-C2H2_6	223 → 248		Domain
PF00096	zf-C2H2	279 → 301	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	307 → 329	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	363 → 385	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	475 → 497	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	503 → 525	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	559 → 581	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	587 → 609	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	615 → 637	Zinc finger, C2H2 type	Domain

Sequence

MDSVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKKWEDQDIEDDHRNQG
KNRRCHMVERLCESRRGSKCGETTSQMPNVNINKETFTGAKPHECSFCGRDFIHHSSLNR
HMRSHTGQKPNEYQEYEKQPCKCKAVGKTFSYHHCFRKHERTHTGVKPYECKQCGKAFIY
YQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHTGKKPYECKQCGKAFICYQSFQR
HKRTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGEKPYKCKECGKAFSFLSSFRRHKRT
HSGEKPYECKECGKAFFYSASFRAHVIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGE
KPYECKRCGKSFSWSISLRLHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYE
CKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQC
GKVFIRSSSFRLHERTHTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAF
LRSSQIRLHERTHTGEKPYQCKQCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSS
SVRIHERSHTGEKPYECKQCGKAFISSSHFRLHERTHMGEKV

Sequence length

642

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF14 (zinc finger protein 14)