Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7556
Gene name	Zinc finger protein 10
Gene symbol	ZNF10
Synonyms (NCBI Gene)	KOX1
Chromosome	12
Chromosome location	12q24.33
Summary	The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. R

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miRTarBase ID	miRNA	Experiments
MIRT1515660	hsa-let-7a	CLIP-seq
MIRT1515661	hsa-let-7b	CLIP-seq
MIRT1515662	hsa-let-7c	CLIP-seq
MIRT1515663	hsa-let-7d	CLIP-seq
MIRT1515664	hsa-let-7e	CLIP-seq
MIRT1515665	hsa-let-7f	CLIP-seq
MIRT1515666	hsa-let-7g	CLIP-seq
MIRT1515667	hsa-let-7i	CLIP-seq
MIRT1515668	hsa-miR-103a	CLIP-seq
MIRT1515669	hsa-miR-107	CLIP-seq
MIRT1515670	hsa-miR-1185	CLIP-seq
MIRT1515671	hsa-miR-1244	CLIP-seq
MIRT1515672	hsa-miR-1245b-3p	CLIP-seq
MIRT1515673	hsa-miR-1266	CLIP-seq
MIRT1515674	hsa-miR-1267	CLIP-seq
MIRT1515675	hsa-miR-1271	CLIP-seq
MIRT1515676	hsa-miR-1304	CLIP-seq
MIRT1515677	hsa-miR-15a	CLIP-seq
MIRT1515678	hsa-miR-15b	CLIP-seq
MIRT1515679	hsa-miR-16	CLIP-seq
MIRT1515680	hsa-miR-182	CLIP-seq
MIRT1515681	hsa-miR-1915	CLIP-seq
MIRT739603	hsa-miR-194	CLIP-seq
MIRT1515682	hsa-miR-195	CLIP-seq
MIRT1515683	hsa-miR-202	CLIP-seq
MIRT1515684	hsa-miR-223	CLIP-seq
MIRT739601	hsa-miR-2277-3p	CLIP-seq
MIRT1515685	hsa-miR-28-5p	CLIP-seq
MIRT1515686	hsa-miR-3074-3p	CLIP-seq
MIRT1515687	hsa-miR-3139	CLIP-seq
MIRT1515688	hsa-miR-3140-3p	CLIP-seq
MIRT1515689	hsa-miR-325	CLIP-seq
MIRT1515690	hsa-miR-3605-5p	CLIP-seq
MIRT1515691	hsa-miR-3664-3p	CLIP-seq
MIRT1515692	hsa-miR-3679-5p	CLIP-seq
MIRT1515693	hsa-miR-371b-5p	CLIP-seq
MIRT1515694	hsa-miR-3919	CLIP-seq
MIRT1515695	hsa-miR-3923	CLIP-seq
MIRT1515696	hsa-miR-3927	CLIP-seq
MIRT1515697	hsa-miR-3935	CLIP-seq
MIRT1515698	hsa-miR-424	CLIP-seq
MIRT1515699	hsa-miR-4276	CLIP-seq
MIRT739600	hsa-miR-4310	CLIP-seq
MIRT1515700	hsa-miR-4433	CLIP-seq
MIRT1515701	hsa-miR-4446-5p	CLIP-seq
MIRT1515702	hsa-miR-4458	CLIP-seq
MIRT1515703	hsa-miR-4459	CLIP-seq
MIRT1515704	hsa-miR-4500	CLIP-seq
MIRT1515705	hsa-miR-450b-5p	CLIP-seq
MIRT1515706	hsa-miR-4518	CLIP-seq
MIRT739602	hsa-miR-4643	CLIP-seq
MIRT1515707	hsa-miR-4687-3p	CLIP-seq
MIRT1515708	hsa-miR-4697-3p	CLIP-seq
MIRT1515709	hsa-miR-4726-3p	CLIP-seq
MIRT1515710	hsa-miR-4768-3p	CLIP-seq
MIRT1515711	hsa-miR-491-3p	CLIP-seq
MIRT1515712	hsa-miR-497	CLIP-seq
MIRT1515713	hsa-miR-501-3p	CLIP-seq
MIRT1515714	hsa-miR-502-3p	CLIP-seq
MIRT1515715	hsa-miR-507	CLIP-seq
MIRT1515716	hsa-miR-518a-5p	CLIP-seq
MIRT1515717	hsa-miR-527	CLIP-seq
MIRT1515718	hsa-miR-549	CLIP-seq
MIRT1515719	hsa-miR-552	CLIP-seq
MIRT1515720	hsa-miR-557	CLIP-seq
MIRT1515721	hsa-miR-708	CLIP-seq
MIRT1515722	hsa-miR-888	CLIP-seq
MIRT1515723	hsa-miR-96	CLIP-seq
MIRT1515724	hsa-miR-98	CLIP-seq
MIRT1515673	hsa-miR-1266	CLIP-seq
MIRT1515674	hsa-miR-1267	CLIP-seq
MIRT1515681	hsa-miR-1915	CLIP-seq
MIRT1515691	hsa-miR-3664-3p	CLIP-seq
MIRT2155641	hsa-miR-4269	CLIP-seq
MIRT1515699	hsa-miR-4276	CLIP-seq
MIRT1515701	hsa-miR-4446-5p	CLIP-seq
MIRT1515706	hsa-miR-4518	CLIP-seq
MIRT1515707	hsa-miR-4687-3p	CLIP-seq
MIRT1515709	hsa-miR-4726-3p	CLIP-seq
MIRT1515660	hsa-let-7a	CLIP-seq
MIRT1515661	hsa-let-7b	CLIP-seq
MIRT1515662	hsa-let-7c	CLIP-seq
MIRT1515663	hsa-let-7d	CLIP-seq
MIRT1515664	hsa-let-7e	CLIP-seq
MIRT1515665	hsa-let-7f	CLIP-seq
MIRT1515666	hsa-let-7g	CLIP-seq
MIRT1515667	hsa-let-7i	CLIP-seq
MIRT1515668	hsa-miR-103a	CLIP-seq
MIRT1515669	hsa-miR-107	CLIP-seq
MIRT2375298	hsa-miR-1238	CLIP-seq
MIRT1515671	hsa-miR-1244	CLIP-seq
MIRT1515676	hsa-miR-1304	CLIP-seq
MIRT1515677	hsa-miR-15a	CLIP-seq
MIRT1515678	hsa-miR-15b	CLIP-seq
MIRT1515679	hsa-miR-16	CLIP-seq
MIRT1515682	hsa-miR-195	CLIP-seq
MIRT1515683	hsa-miR-202	CLIP-seq
MIRT2375299	hsa-miR-28-3p	CLIP-seq
MIRT2375300	hsa-miR-3123	CLIP-seq
MIRT2375301	hsa-miR-3150a-5p	CLIP-seq
MIRT2375302	hsa-miR-3150b-5p	CLIP-seq
MIRT1515689	hsa-miR-325	CLIP-seq
MIRT2375303	hsa-miR-376c	CLIP-seq
MIRT1515694	hsa-miR-3919	CLIP-seq
MIRT1515695	hsa-miR-3923	CLIP-seq
MIRT2375304	hsa-miR-3925-5p	CLIP-seq
MIRT1515696	hsa-miR-3927	CLIP-seq
MIRT1515697	hsa-miR-3935	CLIP-seq
MIRT2375305	hsa-miR-3976	CLIP-seq
MIRT1515698	hsa-miR-424	CLIP-seq
MIRT1515702	hsa-miR-4458	CLIP-seq
MIRT2375306	hsa-miR-4464	CLIP-seq
MIRT1515704	hsa-miR-4500	CLIP-seq
MIRT2375307	hsa-miR-4748	CLIP-seq
MIRT2375308	hsa-miR-4756-3p	CLIP-seq
MIRT2375309	hsa-miR-4795-3p	CLIP-seq
MIRT1515712	hsa-miR-497	CLIP-seq
MIRT1515718	hsa-miR-549	CLIP-seq
MIRT2375310	hsa-miR-802	CLIP-seq
MIRT1515724	hsa-miR-98	CLIP-seq
MIRT1515694	hsa-miR-3919	CLIP-seq
MIRT2464040	hsa-miR-4494	CLIP-seq
MIRT2464041	hsa-miR-4499	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	9016654, 17512541, 23665872, 32296183, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23665872
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	17512541
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
194538	12879	ENSG00000256223

P21506

Protein name

Zinc finger protein 10 (Zinc finger protein KOX1)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	13 → 54	KRAB box	Family
PF00096	zf-C2H2	265 → 287	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	293 → 315	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	321 → 343	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	349 → 371	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	377 → 399	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	405 → 427	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	433 → 455	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	461 → 483	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	489 → 511	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	517 → 539	Zinc finger, C2H2 type	Domain

Sequence

MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKP
DVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARND
LWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGGNCLLPAQLV
LREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKC
PDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEKPYECKECGK
SFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVH
SSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHL
VVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQ
RIHTGEKPYECCQCGKAFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHT
GEQFLTCNQCGTALVNTSNLIGYQTNHIRENAY

Sequence length

573

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF10 (zinc finger protein 10)