Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7555
Gene name Gene Name - the full gene name approved by the HGNC.
CCHC-type zinc finger nucleic acid binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CNBP
Synonyms (NCBI Gene) Gene synonyms aliases
CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also funct
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT052598 hsa-let-7a-5p CLASH 23622248
MIRT051588 hsa-let-7e-5p CLASH 23622248
MIRT051588 hsa-let-7e-5p CLASH 23622248
MIRT050198 hsa-miR-26a-5p CLASH 23622248
MIRT044933 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 23774591
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003727 Function Single-stranded RNA binding IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
116955 13164 ENSG00000169714
Protein
UniProt ID P62633
Protein name CCHC-type zinc finger nucleic acid binding protein (Cellular nucleic acid-binding protein) (CNBP) (Zinc finger protein 9)
Protein function Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00098 zf-CCHC 4 21 Zinc knuckle Domain
PF00098 zf-CCHC 52 69 Zinc knuckle Domain
PF00098 zf-CCHC 72 89 Zinc knuckle Domain
PF00098 zf-CCHC 96 113 Zinc knuckle Domain
PF00098 zf-CCHC 117 134 Zinc knuckle Domain
PF00098 zf-CCHC 135 152 Zinc knuckle Domain
PF00098 zf-CCHC 156 173 Zinc knuckle Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands. {ECO:0000269|PubMed:2562787}.
Sequence
Sequence length 177
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Myotonic dystrophy myotonic dystrophy type 2 N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Astrocytoma Stimulate 17052361
CANVAS syndrome Associate 40113266
Central Nervous System Diseases Associate 35633176
Chemical and Drug Induced Liver Injury Associate 29106686
Diabetes Mellitus Associate 18654640
Endometrial Neoplasms Associate 33577023
Frontotemporal Dementia Associate 37146135
Glioblastoma Associate 27378817
Heredodegenerative Disorders Nervous System Associate 35633176
Insulin Resistance Associate 18654640