Gene Gene information from NCBI Gene database.
Entrez ID 7543
Gene name Zinc finger protein X-linked
Gene symbol ZFX
Synonyms (NCBI Gene)
MRXS37ZNF926
Chromosome X
Chromosome location Xp22.11
Summary This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuc
miRNA miRNA information provided by mirtarbase database.
1010
miRTarBase ID miRNA Experiments Reference
MIRT027367 hsa-miR-101-3p Sequencing 20371350
MIRT027627 hsa-miR-98-5p Microarray 19088304
MIRT042023 hsa-miR-484 CLASH 23622248
MIRT053494 hsa-miR-144-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 22955854
MIRT612296 hsa-miR-8485 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 24831540
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 24831540
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 24831540
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IMP 38325380
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
314980 12869 ENSG00000005889
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17010
Protein name Zinc finger X-chromosomal protein
Protein function Probable transcriptional activator.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04704 Zfx_Zfy_act 70 410 Zfx / Zfy transcription activation region Family
PF00096 zf-C2H2 425 447 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 488 510 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 548 570 Zinc finger, C2H2 type Domain
PF13909 zf-H2C2_5 576 601 Domain
PF00096 zf-C2H2 662 684 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 719 741 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 747 770 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 776 799 Zinc finger, C2H2 type Domain
Sequence
MDEDGLELQQEPNSFFDATGADGTHMDGDQIVVEVQETVFVSDVVDSDITVHNFVPDDPD
SVVIQDVIEDVVIEDVQCPDIMEEADVSETVIIPEQVLDSDVTEEVSLAHCTVPDDVLAS
DITSASMSMPEHVLTGDSIHVSDVGHVGHVGHVEHVVHDSVVEAEIVTDPLTTDVVSEEV
LVADCASEAVIDANGIPVDQQDDDKGNCEDYLMISLDDAGKIEHDGSSGMTMDTESEIDP
CKVDGTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVY
MTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMDDNEIKTFMPIAW
AAAYGNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQ
TAIIIGPDGH
PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKL
TSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLA
VHSKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHS
K
EMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDY
PHKCDMCDKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFR
CKRCRKGFRQQSELKKHMKTH
SGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEY
CKKGFRRPSEKNQHIMRHH
KEVGLP
Sequence length 805
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Intellectual developmental disorder, X-linked, syndromic 37 Pathogenic rs2519900420, rs2519900660, rs748417793, rs2519876529, rs2519220921 RCV003991065
RCV003991066
RCV003991067
RCV003991068
RCV003991069
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
X-LINKED SYNDROMIC COMPLEX NEURODEVELOPMENTAL DISORDER ClinGen, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Azoospermia Nonobstructive Associate 36017582
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 22185393, 29429977, 29753316
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 29758928
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 24066116
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Stimulate 25916205
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Hypertrophic Associate 33757590
★☆☆☆☆
Found in Text Mining only
Cell Transformation Neoplastic Associate 24831540
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 25031734
★☆☆☆☆
Found in Text Mining only
Developmental Disabilities Associate 26740508
★☆☆☆☆
Found in Text Mining only
Gallbladder Neoplasms Associate 26230915
★☆☆☆☆
Found in Text Mining only