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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7536
|
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Splicing factor 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SF1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q13.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3` splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages o |
| UniProt ID |
Q15637
|
| Protein name |
Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) |
| Protein function |
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO: |
| PDB |
1K1G
,
1O0P
,
1OPI
,
2M09
,
2M0G
,
4FXW
,
4FXX
,
7VH9
,
7VPX
,
8PXX
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
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PF16275
|
SF1-HH |
18 → 130 |
Splicing factor 1 helix-hairpin domain |
Domain |
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PF00013
|
KH_1 |
137 → 224 |
KH domain |
Domain |
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PF00098
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zf-CCHC |
278 → 293 |
Zinc knuckle |
Domain |
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| Tissue specificity |
TISSUE SPECIFICITY: Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. {ECO:0000269|PubMed:7912130}. |
| Sequence |
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| Sequence length |
639 |
| Interactions |
View interactions
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