Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7534
Gene name Gene Name - the full gene name approved by the HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YWHAZ
Synonyms (NCBI Gene) Gene synonyms aliases
14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, POPCHAS, YWHAD
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006983 hsa-miR-193b-3p Luciferase reporter assay 21512034
MIRT006983 hsa-miR-193b-3p Reporter assay;Proteomics 21512034
MIRT019886 hsa-miR-375 Reporter assay;Western blot;qRT-PCR;Microarray 20215506
MIRT020711 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT023741 hsa-miR-1-3p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 21621563
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001525 Process Angiogenesis IEA
GO:0003016 Process Respiratory system process IEA
GO:0003723 Function RNA binding HDA 22658674
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601288 12855 ENSG00000164924
Protein
UniProt ID P63104
Protein name 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to
PDB 1IB1 , 1QJA , 1QJB , 2C1J , 2C1N , 2O02 , 2WH0 , 3CU8 , 3NKX , 3RDH , 4BG6 , 4FJ3 , 4HKC , 4IHL , 4N7G , 4N7Y , 4N84 , 4WRQ , 4ZDR , 5D2D , 5D3F , 5EWZ , 5EXA , 5J31 , 5JM4 , 5M35 , 5M36 , 5M37 , 5NAS , 5ULO , 5WXN , 5XY9 , 6EF5 , 6EJL , 6EWW , 6F08 , 6F09 , 6FN9 , 6FNA , 6FNB , 6FNC , 6Q0K , 6RLZ , 6U2H , 6XAG , 6YMO , 6YO8 , 6YOS , 6ZFD , 6ZFG , 7D8H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 9 229 14-3-3 protein Domain
Sequence
Sequence length 245
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Hepatitis B
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Regulation of localization of FOXO transcription factors
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Neurodevelopmental Disorders complex neurodevelopmental disorder N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 30662332
Adenocarcinoma of Lung Associate 28901525, 34285141
Alcoholism Inhibit 21332526
Alzheimer Disease Associate 10840038, 18256261, 26059363, 31989994
Alzheimer Disease Stimulate 32366888
Amyotrophic Lateral Sclerosis Inhibit 30283000
Anodontia Associate 37894839
Arthritis Rheumatoid Associate 37894839
Ascites Associate 18618111
Atherosclerosis Associate 35775826