Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7531
Gene name Gene Name - the full gene name approved by the HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YWHAE
Synonyms (NCBI Gene) Gene synonyms aliases
14-3-3E, HEL2, KCIP-1, MDCR, MDS
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to t
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028656 hsa-miR-30a-5p Proteomics 18668040
MIRT051964 hsa-let-7b-5p CLASH 23622248
MIRT051565 hsa-let-7e-5p CLASH 23622248
MIRT050142 hsa-miR-26a-5p CLASH 23622248
MIRT049920 hsa-miR-30a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IDA 12917326
GO:0001764 Process Neuron migration IEA
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 20451243
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 22607805
GO:0003064 Process Regulation of heart rate by hormone NAS 11953308
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605066 12851 ENSG00000108953
Protein
UniProt ID P62258
Protein name 14-3-3 protein epsilon (14-3-3E)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubM
PDB 2BR9 , 3UAL , 3UBW , 6EIH , 7C8E , 7V9B , 8DGM , 8DGN , 8DGP , 8DP5 , 8Q1S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 10 232 14-3-3 protein Domain
Sequence
Sequence length 255
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
NOD-like receptor signaling pathway
Neurotrophin signaling pathway
Hepatitis C
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
Signaling by Hippo
NADE modulates death signalling
Regulation of PLK1 Activity at G2/M Transition
Regulation of HSF1-mediated heat shock response
HSF1 activation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RAB GEFs exchange GTP for GDP on RABs
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Neurodevelopmental Disorders complex neurodevelopmental disorder N/A N/A GenCC
Prostate cancer Prostate cancer Together, results indicate that UBR5 and YWHAE are overexpressed in some PCs, which might be favorable for olaparib response as our in vitro data showed that KO of UBR5 or YWHAE caused olaparib resistance in CRPC cells. 35933519 CBGDA
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 30662332
AIDS Associated Nephropathy Associate 23982958
Alcohol Related Disorders Associate 23035971
Alzheimer Disease Associate 33254518
Atrial Fibrillation Associate 32478689
Autism Spectrum Disorder Stimulate 23813913
Autistic Disorder Associate 23035971
Back Pain Associate 26945340
Bipolar Disorder Associate 23035971
Body Dysmorphic Disorders Associate 23035971