XPO1 (exportin 1)

Gene

• Entrez ID: 7514
• Gene name: Exportin 1
• Gene symbol: XPO1
• Synonyms (NCBI Gene): CRM-1, CRM1, emb, exp1
• Chromosome: 2
• Chromosome location: 2p15
• Summary: This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellula

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057520009	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057520010	T>A,G	Likely-pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016294	hsa-miR-193b-3p	Proteomics	21512034
MIRT020549	hsa-miR-155-5p	Proteomics	18668040
MIRT026224	hsa-miR-192-5p	Microarray	19074876
MIRT028476	hsa-miR-30a-5p	Proteomics	18668040
MIRT031490	hsa-miR-16-5p	Proteomics	18668040
MIRT050787	hsa-miR-17-3p	CLASH	23622248
MIRT049604	hsa-miR-92a-3p	CLASH	23622248
MIRT046310	hsa-miR-23b-3p	CLASH	23622248
MIRT045717	hsa-miR-125a-5p	CLASH	23622248
MIRT036257	hsa-miR-1236-3p	CLASH	23622248
MIRT545981	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT545980	hsa-miR-4453	PAR-CLIP	20371350
MIRT545979	hsa-miR-4538	PAR-CLIP	20371350
MIRT545981	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT545980	hsa-miR-4453	PAR-CLIP	21572407
MIRT545979	hsa-miR-4538	PAR-CLIP	21572407
MIRT028476	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT206889	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT206887	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT206890	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT206888	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT545981	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT545980	hsa-miR-4453	PAR-CLIP	21572407
MIRT545979	hsa-miR-4538	PAR-CLIP	21572407
MIRT545978	hsa-miR-4495	PAR-CLIP	21572407
MIRT439277	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439276	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439277	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT439276	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT733811	hsa-let-7f-2-3p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR	31570982
MIRT545981	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT545980	hsa-miR-4453	PAR-CLIP	20371350
MIRT545979	hsa-miR-4538	PAR-CLIP	20371350
MIRT545981	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT545980	hsa-miR-4453	PAR-CLIP	21572407
MIRT545979	hsa-miR-4538	PAR-CLIP	21572407
MIRT028476	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT206889	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT206887	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT206890	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT206888	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT545981	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT545980	hsa-miR-4453	PAR-CLIP	21572407
MIRT545979	hsa-miR-4538	PAR-CLIP	21572407
MIRT545978	hsa-miR-4495	PAR-CLIP	21572407
MIRT1496452	hsa-miR-133a	CLIP-seq
MIRT1496453	hsa-miR-133b	CLIP-seq
MIRT1496454	hsa-miR-142-3p	CLIP-seq
MIRT1496455	hsa-miR-190	CLIP-seq
MIRT1496456	hsa-miR-190b	CLIP-seq
MIRT1496457	hsa-miR-1910	CLIP-seq
MIRT1496458	hsa-miR-2053	CLIP-seq
MIRT1496459	hsa-miR-2054	CLIP-seq
MIRT1496460	hsa-miR-2116	CLIP-seq
MIRT1496461	hsa-miR-219-1-3p	CLIP-seq
MIRT1496462	hsa-miR-224	CLIP-seq
MIRT1496463	hsa-miR-30a	CLIP-seq
MIRT1496464	hsa-miR-30b	CLIP-seq
MIRT1496465	hsa-miR-30c	CLIP-seq
MIRT1496466	hsa-miR-30d	CLIP-seq
MIRT1496467	hsa-miR-30e	CLIP-seq
MIRT1496468	hsa-miR-3121-3p	CLIP-seq
MIRT1496469	hsa-miR-3140-3p	CLIP-seq
MIRT1496470	hsa-miR-3152-5p	CLIP-seq
MIRT1496471	hsa-miR-33a	CLIP-seq
MIRT1496472	hsa-miR-33b	CLIP-seq
MIRT1496473	hsa-miR-361-3p	CLIP-seq
MIRT1496474	hsa-miR-3616-5p	CLIP-seq
MIRT1496475	hsa-miR-3647-5p	CLIP-seq
MIRT1496476	hsa-miR-3671	CLIP-seq
MIRT1496477	hsa-miR-3682-3p	CLIP-seq
MIRT1496478	hsa-miR-374c	CLIP-seq
MIRT1496479	hsa-miR-3929	CLIP-seq
MIRT1496480	hsa-miR-4255	CLIP-seq
MIRT1496481	hsa-miR-4305	CLIP-seq
MIRT1496482	hsa-miR-4311	CLIP-seq
MIRT1496483	hsa-miR-4315	CLIP-seq
MIRT1496484	hsa-miR-4419b	CLIP-seq
MIRT1496485	hsa-miR-4424	CLIP-seq
MIRT1496486	hsa-miR-4444	CLIP-seq
MIRT1496487	hsa-miR-4478	CLIP-seq
MIRT1496488	hsa-miR-450b-5p	CLIP-seq
MIRT1496489	hsa-miR-4528	CLIP-seq
MIRT1496490	hsa-miR-455-3p	CLIP-seq
MIRT1496491	hsa-miR-4642	CLIP-seq
MIRT1496492	hsa-miR-4659a-3p	CLIP-seq
MIRT1496493	hsa-miR-4659b-3p	CLIP-seq
MIRT1496494	hsa-miR-4666-5p	CLIP-seq
MIRT1496495	hsa-miR-4677-5p	CLIP-seq
MIRT1496496	hsa-miR-4690-3p	CLIP-seq
MIRT1496497	hsa-miR-4762-5p	CLIP-seq
MIRT1496498	hsa-miR-4774-3p	CLIP-seq
MIRT1496499	hsa-miR-4775	CLIP-seq
MIRT1496500	hsa-miR-4790-5p	CLIP-seq
MIRT1496501	hsa-miR-501-3p	CLIP-seq
MIRT1496502	hsa-miR-502-3p	CLIP-seq
MIRT1496503	hsa-miR-507	CLIP-seq
MIRT1496504	hsa-miR-520d-5p	CLIP-seq
MIRT1496505	hsa-miR-524-5p	CLIP-seq
MIRT1496506	hsa-miR-557	CLIP-seq
MIRT1496507	hsa-miR-562	CLIP-seq
MIRT1496508	hsa-miR-569	CLIP-seq
MIRT1496509	hsa-miR-571	CLIP-seq
MIRT1496510	hsa-miR-573	CLIP-seq
MIRT1496511	hsa-miR-590-3p	CLIP-seq
MIRT1496512	hsa-miR-607	CLIP-seq
MIRT1496513	hsa-miR-645	CLIP-seq
MIRT1496514	hsa-miR-655	CLIP-seq
MIRT2149435	hsa-miR-103a	CLIP-seq
MIRT2149436	hsa-miR-107	CLIP-seq
MIRT2149437	hsa-miR-1238	CLIP-seq
MIRT2149438	hsa-miR-1324	CLIP-seq
MIRT1496452	hsa-miR-133a	CLIP-seq
MIRT1496453	hsa-miR-133b	CLIP-seq
MIRT1496454	hsa-miR-142-3p	CLIP-seq
MIRT1496455	hsa-miR-190	CLIP-seq
MIRT1496456	hsa-miR-190b	CLIP-seq
MIRT1496457	hsa-miR-1910	CLIP-seq
MIRT2149439	hsa-miR-2052	CLIP-seq
MIRT1496460	hsa-miR-2116	CLIP-seq
MIRT1496462	hsa-miR-224	CLIP-seq
MIRT1496463	hsa-miR-30a	CLIP-seq
MIRT1496464	hsa-miR-30b	CLIP-seq
MIRT1496465	hsa-miR-30c	CLIP-seq
MIRT1496466	hsa-miR-30d	CLIP-seq
MIRT1496467	hsa-miR-30e	CLIP-seq
MIRT1496471	hsa-miR-33a	CLIP-seq
MIRT1496472	hsa-miR-33b	CLIP-seq
MIRT1496474	hsa-miR-3616-5p	CLIP-seq
MIRT1496475	hsa-miR-3647-5p	CLIP-seq
MIRT1496477	hsa-miR-3682-3p	CLIP-seq
MIRT2149440	hsa-miR-371-5p	CLIP-seq
MIRT2149441	hsa-miR-371b-5p	CLIP-seq
MIRT1496480	hsa-miR-4255	CLIP-seq
MIRT2149442	hsa-miR-4284	CLIP-seq
MIRT1496481	hsa-miR-4305	CLIP-seq
MIRT1496482	hsa-miR-4311	CLIP-seq
MIRT1496483	hsa-miR-4315	CLIP-seq
MIRT2149443	hsa-miR-4422	CLIP-seq
MIRT1496485	hsa-miR-4424	CLIP-seq
MIRT1496486	hsa-miR-4444	CLIP-seq
MIRT2149444	hsa-miR-4493	CLIP-seq
MIRT1496489	hsa-miR-4528	CLIP-seq
MIRT1496490	hsa-miR-455-3p	CLIP-seq
MIRT1496491	hsa-miR-4642	CLIP-seq
MIRT1496495	hsa-miR-4677-5p	CLIP-seq
MIRT1496496	hsa-miR-4690-3p	CLIP-seq
MIRT2149445	hsa-miR-4719	CLIP-seq
MIRT1496499	hsa-miR-4775	CLIP-seq
MIRT1496500	hsa-miR-4790-5p	CLIP-seq
MIRT2149446	hsa-miR-500a	CLIP-seq
MIRT1496501	hsa-miR-501-3p	CLIP-seq
MIRT2149447	hsa-miR-501-5p	CLIP-seq
MIRT1496502	hsa-miR-502-3p	CLIP-seq
MIRT1496508	hsa-miR-569	CLIP-seq
MIRT1496510	hsa-miR-573	CLIP-seq
MIRT2149435	hsa-miR-103a	CLIP-seq
MIRT2149436	hsa-miR-107	CLIP-seq
MIRT2149438	hsa-miR-1324	CLIP-seq
MIRT1496455	hsa-miR-190	CLIP-seq
MIRT1496456	hsa-miR-190b	CLIP-seq
MIRT1496457	hsa-miR-1910	CLIP-seq
MIRT2149439	hsa-miR-2052	CLIP-seq
MIRT1496458	hsa-miR-2053	CLIP-seq
MIRT1496459	hsa-miR-2054	CLIP-seq
MIRT1496460	hsa-miR-2116	CLIP-seq
MIRT1496461	hsa-miR-219-1-3p	CLIP-seq
MIRT1496463	hsa-miR-30a	CLIP-seq
MIRT1496464	hsa-miR-30b	CLIP-seq
MIRT1496465	hsa-miR-30c	CLIP-seq
MIRT1496466	hsa-miR-30d	CLIP-seq
MIRT1496467	hsa-miR-30e	CLIP-seq
MIRT1496474	hsa-miR-3616-5p	CLIP-seq
MIRT1496475	hsa-miR-3647-5p	CLIP-seq
MIRT1496477	hsa-miR-3682-3p	CLIP-seq
MIRT1496478	hsa-miR-374c	CLIP-seq
MIRT1496480	hsa-miR-4255	CLIP-seq
MIRT2149442	hsa-miR-4284	CLIP-seq
MIRT1496481	hsa-miR-4305	CLIP-seq
MIRT1496482	hsa-miR-4311	CLIP-seq
MIRT1496483	hsa-miR-4315	CLIP-seq
MIRT2149443	hsa-miR-4422	CLIP-seq
MIRT1496485	hsa-miR-4424	CLIP-seq
MIRT1496486	hsa-miR-4444	CLIP-seq
MIRT2149444	hsa-miR-4493	CLIP-seq
MIRT1496489	hsa-miR-4528	CLIP-seq
MIRT1496490	hsa-miR-455-3p	CLIP-seq
MIRT1496492	hsa-miR-4659a-3p	CLIP-seq
MIRT1496493	hsa-miR-4659b-3p	CLIP-seq
MIRT1496494	hsa-miR-4666-5p	CLIP-seq
MIRT1496495	hsa-miR-4677-5p	CLIP-seq
MIRT2149445	hsa-miR-4719	CLIP-seq
MIRT1496499	hsa-miR-4775	CLIP-seq
MIRT1496500	hsa-miR-4790-5p	CLIP-seq
MIRT2149446	hsa-miR-500a	CLIP-seq
MIRT1496501	hsa-miR-501-3p	CLIP-seq
MIRT2149447	hsa-miR-501-5p	CLIP-seq
MIRT1496502	hsa-miR-502-3p	CLIP-seq
MIRT1496508	hsa-miR-569	CLIP-seq
MIRT1496509	hsa-miR-571	CLIP-seq
MIRT1496510	hsa-miR-573	CLIP-seq
MIRT1496511	hsa-miR-590-3p	CLIP-seq
MIRT1496513	hsa-miR-645	CLIP-seq
MIRT1496514	hsa-miR-655	CLIP-seq
MIRT1496470	hsa-miR-3152-5p	CLIP-seq
MIRT1496473	hsa-miR-361-3p	CLIP-seq
MIRT1496496	hsa-miR-4690-3p	CLIP-seq
MIRT1496498	hsa-miR-4774-3p	CLIP-seq
MIRT2149437	hsa-miR-1238	CLIP-seq
MIRT1496452	hsa-miR-133a	CLIP-seq
MIRT1496453	hsa-miR-133b	CLIP-seq
MIRT2663552	hsa-miR-2467-3p	CLIP-seq
MIRT2663553	hsa-miR-3678-3p	CLIP-seq
MIRT2663554	hsa-miR-3919	CLIP-seq
MIRT1496491	hsa-miR-4642	CLIP-seq
MIRT1496499	hsa-miR-4775	CLIP-seq
MIRT1496504	hsa-miR-520d-5p	CLIP-seq
MIRT1496505	hsa-miR-524-5p	CLIP-seq
MIRT2663555	hsa-miR-892a	CLIP-seq
MIRT2149437	hsa-miR-1238	CLIP-seq
MIRT1496452	hsa-miR-133a	CLIP-seq
MIRT1496453	hsa-miR-133b	CLIP-seq
MIRT2663552	hsa-miR-2467-3p	CLIP-seq
MIRT2663553	hsa-miR-3678-3p	CLIP-seq
MIRT2663554	hsa-miR-3919	CLIP-seq
MIRT1496491	hsa-miR-4642	CLIP-seq
MIRT1496499	hsa-miR-4775	CLIP-seq
MIRT1496504	hsa-miR-520d-5p	CLIP-seq
MIRT1496505	hsa-miR-524-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Activation	22284678
TP53	Repression	22284678

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000054	Process	Ribosomal subunit export from nucleus	IMP	12724356
GO:0000055	Process	Ribosomal large subunit export from nucleus	IBA
GO:0000055	Process	Ribosomal large subunit export from nucleus	IMP	12773398
GO:0000056	Process	Ribosomal small subunit export from nucleus	IBA
GO:0000056	Process	Ribosomal small subunit export from nucleus	IMP	12773398
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000776	Component	Kinetochore	IDA	17363900
GO:0003723	Function	RNA binding	IEA
GO:0005049	Function	Nuclear export signal receptor activity	IBA
GO:0005049	Function	Nuclear export signal receptor activity	IDA	29666234
GO:0005049	Function	Nuclear export signal receptor activity	IEA
GO:0005049	Function	Nuclear export signal receptor activity	IMP	12724356, 12773398
GO:0005049	Function	Nuclear export signal receptor activity	ISS	31340148
GO:0005049	Function	Nuclear export signal receptor activity	TAS
GO:0005515	Function	Protein binding	IPI	10358091, 10557333, 11000203, 11545741, 11932251, 12724356, 15161933, 16302269, 16314522, 16319068, 17099693, 17268548, 18952844, 19339969, 19339972, 19955415, 20485264, 20826784, 20921223, 21378169, 22022502, 22084111, 22250199, 22427340, 22500989, 22730302, 23850451, 24169621, 258
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	TAS	9368044
GO:0005642	Component	Annulate lamellae	IDA	12210765
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS	9368044
GO:0005730	Component	Nucleolus	IDA	23782956
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	23782956
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9368044
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006406	Process	MRNA export from nucleus	IEA
GO:0006406	Process	MRNA export from nucleus	ISS	31340148
GO:0006611	Process	Protein export from nucleus	IC	21378169
GO:0006611	Process	Protein export from nucleus	IDA	22250199, 29666234
GO:0006611	Process	Protein export from nucleus	IEA
GO:0006611	Process	Protein export from nucleus	IEA
GO:0006611	Process	Protein export from nucleus	IMP	22427340
GO:0006611	Process	Protein export from nucleus	IMP	12773398
GO:0006611	Process	Protein export from nucleus	IPI	29666234
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	IMP	11000203
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0010824	Process	Regulation of centrosome duplication	IEA
GO:0015030	Component	Cajal body	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019904	Function	Protein domain specific binding	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	29666234
GO:0032991	Component	Protein-containing complex	IDA	10557333, 29666234
GO:0034504	Process	Protein localization to nucleus	IEA
GO:0042176	Process	Regulation of protein catabolic process	IEA
GO:0042254	Process	Ribosome biogenesis	IMP	12724356
GO:0046825	Process	Regulation of protein export from nucleus	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0071401	Process	Cellular response to triglyceride	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IEA
GO:1902075	Process	Cellular response to salt	IEA
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582

Other IDs

• MIM: 602559
• HGNC: 12825
• e!Ensembl: ENSG00000082898

Protein

• UniProt ID: O14980
• Protein name: Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
• Protein function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in i
• PDB: 1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS, 6TVO, 7B51, 9B62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03810	IBN_N	46 → 112	Importin-beta N-terminal domain	Family
  PF08389	Xpo1	123 → 268	Exportin 1-like protein	Family
  PF18777	CRM1_repeat	345 → 381	Chromosome region maintenance or exportin repeat	Repeat
  PF18784	CRM1_repeat_2	405 → 472	CRM1 / Exportin repeat 2	Repeat
  PF18787	CRM1_repeat_3	485 → 535	CRM1 / Exportin repeat 3	Repeat
  PF08767	CRM1_C	709 → 1027	CRM1 C terminal	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269|PubMed:9049309, ECO
• Sequence:

  MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW
  TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV
  EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD
  FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY
  IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL
  NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV
  EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM
  VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL
  HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII
  ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV
  QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL
  PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV
  YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL
  LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE
  YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL
  LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST
  SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV
  QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD

• Sequence length: 1071

Pathways

KEGG:

Ribosome biogenesis in eukaryotes
Nucleocytoplasmic transport
Viral life cycle - HIV-1
Influenza A
Human T-cell leukemia virus 1 infection

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Hypertension	Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	25242053
Adenomatous Polyposis Coli	Associate	15678162
Asthma	Associate	35751199
Autism Spectrum Disorder	Associate	21750575
Autistic Disorder	Associate	21750575
beta Thalassemia	Associate	33054049
Brain Damage Chronic	Associate	36807877
Breast Neoplasms	Associate	33117284
Carcinogenesis	Associate	11287420, 12861014, 39178254
Carcinoma Hepatocellular	Associate	31088931, 31371628, 33856525, 36791564, 39178254
Carcinoma Non Small Cell Lung	Associate	34482103, 37925171
Cardiomyopathies	Associate	25137373
Cardiomyopathy Dilated	Associate	25137373
Central Nervous System Vascular Malformations	Associate	36807877
Cholangiocarcinoma	Associate	28882106, 36200270
Colorectal Neoplasms	Associate	25996664, 31870117
Communication Disorders	Associate	21750575
COVID 19	Associate	32344305, 36859333
Death	Associate	33580200
Dementia	Associate	34321086
Developmental Disabilities	Associate	35468861
Drug Related Side Effects and Adverse Reactions	Inhibit	23588715, 37801604
Endometrial Neoplasms	Associate	36589683
Gastrointestinal Neoplasms	Associate	36681091
Genetic Diseases Inborn	Associate	33494994
Genomic Instability	Associate	35014928
Glioblastoma	Associate	37712615
Glucose Intolerance	Associate	15128734
Hearing Loss	Associate	36807877
Hematologic Neoplasms	Associate	34165175
Hepatitis Chronic	Associate	11287420
Hodgkin Disease	Associate	27312795, 27479820, 29650799, 30108156, 31816062, 32079702
Hypoxia Brain	Associate	25793203
Infections	Associate	33580200
Kidney Neoplasms	Associate	36195086
Laryngeal Neoplasms	Associate	28269752, 38031942
Leukemia	Associate	24902788, 27114368, 27613868, 27634897, 31755865
Leukemia B Cell	Associate	27469216, 37523714
Leukemia Lymphocytic Chronic B Cell	Associate	22086416, 25480502, 26053404, 27060156, 27468087, 27469216, 28399885, 33325634, 35014928, 36566271, 37955424
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	25573989
Leukemia Myeloid Acute	Associate	16720834, 23564911, 25531824, 26438511, 31755865, 34446939, 35347147, 37047788, 37473530, 38019903, 38429501, 38608356
Leukemia Plasma Cell	Associate	23588715
Leukemia Prolymphocytic T Cell	Associate	30924136, 31974418, 37528310
Lymphatic Metastasis	Associate	28373767
Lymphatic Metastasis	Stimulate	38031942
Lymphoma	Associate	31752970, 37801604
Lymphoma B Cell	Associate	26819451, 27312795, 27479820, 31816062
Lymphoma Large B Cell Diffuse	Associate	36722323, 37801604
Lymphoma Mantle Cell	Associate	26340096, 28388555, 32961552, 37880950
Lymphoma Non Hodgkin	Associate	31594826
Melanoma	Associate	22832492, 30108156
Mental Disorders	Associate	21750575
Microcephaly	Associate	36807877
Mitochondrial Diseases	Associate	36672210
Mosaic variegated aneuploidy syndrome	Associate	11593014
Multiple Myeloma	Associate	23588715, 35643867, 37964302
Myotonic Dystrophy	Associate	21637295
Neoplasm Metastasis	Associate	22832492, 28373767
Neoplasm Metastasis	Inhibit	31752970
Neoplasm Metastasis	Stimulate	38031942
Neoplasm Residual	Associate	27479820
Neoplasms	Associate	18306389, 19117056, 20826784, 24739265, 25996664, 26340096, 26549027, 26573568, 26991404, 27312238, 27634897, 29973205, 30037299, 30108156, 30118500, 31088931, 31752970, 31870117, 32520643, 32882917, 33325634, 33856525, 33883894, 34003336, 34482103, 36200270, 36418423, 36589683, 36681091, 36722323, 36827679, 37801604, 38019903, 39177040, 39178254, 39217152
Neoplasms	Inhibit	23588715, 38031942
Neoplasms	Stimulate	25026284
Neuroblastoma	Associate	35197448
Osteosarcoma	Associate	33856525
Ovarian Neoplasms	Associate	18306389, 26055813, 34898375
Pancreatic Neoplasms	Associate	36200270
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	30596398, 35355406
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Stimulate	38429501
Primary Ovarian Insufficiency	Associate	33036707
Progeria	Associate	31305018, 36672210
Prostatic Neoplasms	Associate	24391718, 25026284, 26549027, 31018022
Rhabdoid Tumor	Associate	36195086, 36370692
Sarcoma Kaposi	Associate	33414399
Squamous Cell Carcinoma of Head and Neck	Stimulate	39177040
Stomach Neoplasms	Associate	28373767, 31088931, 31569391
Uterine Cervical Neoplasms	Associate	19117056
Virus Diseases	Associate	36859333
Wilms Tumor	Associate	36195086, 36370692
Zoster Sine Herpete	Associate	34165175