Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7476
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 7A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT7A
Synonyms (NCBI Gene) Gene synonyms aliases
SANTOS, Wnt-7a
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fat
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs75651130 G>A,C Conflicting-interpretations-of-pathogenicity Synonymous variant, coding sequence variant, missense variant
rs104893832 C>T Pathogenic Missense variant, coding sequence variant
rs104893835 G>A Pathogenic Missense variant, coding sequence variant
rs149363953 G>A Conflicting-interpretations-of-pathogenicity Coding sequence variant, synonymous variant
rs149962459 C>T Conflicting-interpretations-of-pathogenicity Coding sequence variant, synonymous variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT054418 hsa-miR-195-5p Luciferase reporter assay, Western blot 24520312
MIRT054420 hsa-miR-497-5p Luciferase reporter assay, Western blot 24520312
MIRT607119 hsa-miR-8485 HITS-CLIP 23313552
MIRT607118 hsa-miR-329-3p HITS-CLIP 23313552
MIRT607117 hsa-miR-362-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000578 Process Embryonic axis specification IMP 16826533
GO:0001502 Process Cartilage condensation IDA 17202865
GO:0001525 Process Angiogenesis IEA
GO:0002062 Process Chondrocyte differentiation IDA 17202865
GO:0005102 Function Signaling receptor binding IPI 12857724
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601570 12786 ENSG00000154764
Protein
UniProt ID O00755
Protein name Protein Wnt-7a
Protein function Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patt
PDB 4UZQ , 8TZO , 8TZP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 40 349 wnt family Family
Tissue specificity TISSUE SPECIFICITY: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
Sequence
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  WNT ligand biogenesis and trafficking
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
11796754
Anonychia ANONYCHIA rs74315420, rs74315421, rs74315422, rs74315423, rs387907026, rs387907027, rs387907028, rs780261665, rs775644973, rs370554150
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Ectrodactyly Ectrodactyly rs1850314485
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 22491060
Adenocarcinoma of Lung Associate 30353687, 35325730
Anophthalmia with pulmonary hypoplasia Associate 30361522
Bipolar Disorder Associate 18606951
Carcinogenesis Associate 23321718, 26055144
Carcinoma Hepatocellular Inhibit 31886205
Carcinoma Non Small Cell Lung Associate 15705594, 16835228, 20501643, 23056560, 23237220, 24204697, 25653486
Carcinoma Non Small Cell Lung Inhibit 32554486
Carcinoma Pancreatic Ductal Associate 30361522
Carcinoma Renal Cell Associate 23056560