Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7473
Gene name Gene Name - the full gene name approved by the HGNC.	Wnt family member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WNT3
Synonyms (NCBI Gene) Gene synonyms aliases	INT4, TETAMS
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.31-q21.32
Summary Summary of gene provided in NCBI Entrez Gene.	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog

Show/Hide all(58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018503	hsa-miR-335-5p	Microarray	18185580
MIRT024672	hsa-miR-215-5p	Microarray	19074876
MIRT026683	hsa-miR-192-5p	Microarray	19074876
MIRT036062	hsa-miR-1301-3p	CLASH	23622248
MIRT696724	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT696723	hsa-miR-5684	HITS-CLIP	23313552
MIRT696722	hsa-miR-3667-3p	HITS-CLIP	23313552
MIRT696721	hsa-miR-659-5p	HITS-CLIP	23313552
MIRT696720	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT696719	hsa-miR-3685	HITS-CLIP	23313552
MIRT463929	hsa-miR-1321	PAR-CLIP	23592263
MIRT463928	hsa-miR-4739	PAR-CLIP	23592263
MIRT463927	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT463926	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT463925	hsa-miR-4487	PAR-CLIP	23592263
MIRT463924	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT463923	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT463922	hsa-miR-4419a	PAR-CLIP	23592263
MIRT463921	hsa-miR-4510	PAR-CLIP	23592263
MIRT463920	hsa-miR-6127	PAR-CLIP	23592263
MIRT463919	hsa-miR-6129	PAR-CLIP	23592263
MIRT463918	hsa-miR-6130	PAR-CLIP	23592263
MIRT463917	hsa-miR-6133	PAR-CLIP	23592263
MIRT463915	hsa-miR-3665	PAR-CLIP	23592263
MIRT463916	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT463914	hsa-miR-6077	PAR-CLIP	23592263
MIRT463913	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT463912	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT463911	hsa-miR-4710	PAR-CLIP	23592263
MIRT463910	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT735183	hsa-miR-206	Immunohistochemistry (IHC), qRT-PCR, In situ hybridization	32722078
MIRT696724	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT696723	hsa-miR-5684	HITS-CLIP	23313552
MIRT696722	hsa-miR-3667-3p	HITS-CLIP	23313552
MIRT696721	hsa-miR-659-5p	HITS-CLIP	23313552
MIRT696720	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT696719	hsa-miR-3685	HITS-CLIP	23313552
MIRT463929	hsa-miR-1321	PAR-CLIP	23592263
MIRT463928	hsa-miR-4739	PAR-CLIP	23592263
MIRT463927	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT463926	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT463925	hsa-miR-4487	PAR-CLIP	23592263
MIRT463924	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT463923	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT463922	hsa-miR-4419a	PAR-CLIP	23592263
MIRT463921	hsa-miR-4510	PAR-CLIP	23592263
MIRT463920	hsa-miR-6127	PAR-CLIP	23592263
MIRT463919	hsa-miR-6129	PAR-CLIP	23592263
MIRT463918	hsa-miR-6130	PAR-CLIP	23592263
MIRT463917	hsa-miR-6133	PAR-CLIP	23592263
MIRT463915	hsa-miR-3665	PAR-CLIP	23592263
MIRT463916	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT463914	hsa-miR-6077	PAR-CLIP	23592263
MIRT463913	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT463912	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT463911	hsa-miR-4710	PAR-CLIP	23592263
MIRT463910	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT756009	hsa-miR-3198	Luciferase reporter assay, Western blotting, qRT-PCR	38536597

Show/Hide all(48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IMP	15588944
GO:0001707	Process	Mesoderm formation	IEA
GO:0005109	Function	Frizzled binding	IBA	21873635
GO:0005109	Function	Frizzled binding	IPI	10557084, 18313787
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	18313787, 21314951, 26902720
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	TAS	18313787
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007276	Process	Gamete generation	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0009948	Process	Anterior/posterior axis specification	IEA
GO:0009950	Process	Dorsal/ventral axis specification	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	25640183
GO:0016055	Process	Wnt signaling pathway	TAS
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IEA
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0030182	Process	Neuron differentiation	ISS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0031012	Component	Extracellular matrix	IEA
GO:0035115	Process	Embryonic forelimb morphogenesis	IEA
GO:0035116	Process	Embryonic hindlimb morphogenesis	IEA
GO:0044338	Process	Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	IMP	20039315
GO:0044339	Process	Canonical Wnt signaling pathway involved in osteoblast differentiation	IMP	20039315
GO:0045165	Process	Cell fate commitment	IBA	21873635
GO:0048018	Function	Receptor ligand activity	IC	18044981
GO:0048018	Function	Receptor ligand activity	IDA	10557084, 28733458
GO:0048697	Process	Positive regulation of collateral sprouting in absence of injury	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0050767	Process	Regulation of neurogenesis	IMP	25640183
GO:0060064	Process	Spemann organizer formation at the anterior end of the primitive streak	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IBA	21873635
GO:0060070	Process	Canonical Wnt signaling pathway	IDA	10557084, 15588944, 18044981, 28733458
GO:0060070	Process	Canonical Wnt signaling pathway	TAS	24115276
GO:0060174	Process	Limb bud formation	IMP	14872406
GO:0060323	Process	Head morphogenesis	IEA
GO:0061180	Process	Mammary gland epithelium development	IEP	8168088
GO:0070062	Component	Extracellular exosome	TAS
GO:0071300	Process	Cellular response to retinoic acid	ISS
GO:0072089	Process	Stem cell proliferation	IMP	25640183
GO:1904954	Process	Canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	IMP	25640183
GO:1905474	Process	Canonical Wnt signaling pathway involved in stem cell proliferation	IDA	25640183
GO:1990909	Component	Wnt signalosome	IC	10557084
GO:1990909	Component	Wnt signalosome	NAS	24115276

MIM	HGNC	e!Ensembl
165330	12782	ENSG00000108379

Protein

UniProt ID

P56703

Protein name

Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)

Protein function

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for nor

PDB

6AHY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00110	wnt	47 → 355	wnt family	Family

Sequence

MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

Sequence length

355

Interactions

View interactions

	KEGG		Reactome
	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking

Show/Hide Causal Diseases (11)

Disease term	Disease name	dbSNP ID	References
Causal
Agenesis of corpus callosum	Agenesis of corpus callosum	rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	30061737
Bladder exstrophy and epispadias complex	Bladder Exstrophy and Epispadias Complex	rs786205887
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683
Cataract	Cataract	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322 View all (150 more)
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Hydrocephalus	Hydrocephalus	rs387907320, rs369384363, rs387907321, rs372127610, rs770273135, rs797045095, rs797045707, rs769795916, rs781251438, rs922703465, rs376078512, rs1567043467, rs1587149916, rs1586841546
Microphthalmos	Microphthalmos	rs794726862, rs1329285216
Optic atrophy	Optic Atrophy	rs121434508, rs267607017, rs80356524, rs80356525, rs879255560, rs104893753, rs80356529, rs397515360, rs104893620, rs199476104, rs199476112, rs199476118, rs398124298, rs770066665, rs398124299 View all (37 more)
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	24511991, 21812969, 22451204, 21738487
Tetraamelia syndrome	Tetraamelia multiple malformations, TETRAAMELIA SYNDROME, AUTOSOMAL RECESSIVE	rs104894653, rs1554579568, rs1554576888	14872406

Show/Hide Unknown Diseases (9)

Disease term	Disease name	Evidence	References	Source
Unknown
Celiac disease	Celiac Disease, Celiac disease		20190752	ClinVar, GWAS
Pulmonary hypoplasia	Congenital hypoplasia of lung			ClinVar
Mental depression	Major Depressive Disorder		29942085	ClinVar
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation		30061737	ClinVar
Coronary artery disease	Coronary artery disease			GWAS
Neuroticism	Neuroticism			GWAS
Atrial Fibrillation	Atrial Fibrillation			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Schizophrenia	Schizophrenia			GWAS

Show/Hide Text Mining Associations (59)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Radiation Syndrome	Associate	33476246, 35680903, 37676284, 38499035
Alzheimer Disease	Associate	31504236, 36191742
Amyotrophic Lateral Sclerosis	Stimulate	30924074
Aortic Valve Stenosis	Associate	29227539
Autism Spectrum Disorder	Associate	37907504
Bladder Exstrophy	Associate	34355505
Breast Neoplasms	Associate	23071104, 30651373
Carcinogenesis	Associate	17767013, 29565490
Carcinoma Hepatocellular	Associate	18313787, 18577996, 36275697
Carcinoma Non Small Cell Lung	Stimulate	29565490
Celiac Disease	Associate	35208504
Cleft Lip	Associate	20890934
Cleft Palate	Associate	26505415
Cognition Disorders	Associate	37286376
Colorectal Neoplasms	Associate	33331430, 33891491
COVID 19	Associate	34183789, 37286376
Crohn Disease	Associate	26512113
Drug Hypersensitivity	Associate	37864206
Endometrial Neoplasms	Inhibit	9099960
Esophageal Squamous Cell Carcinoma	Associate	31851619
Essential Hypertension	Associate	32392180
Gallbladder Diseases	Associate	26111189
Glioma	Associate	32181818, 34657400
Growth Disorders	Stimulate	15588944
Heart Defects Congenital	Associate	33463545
Hematologic Diseases	Associate	37676284
Heterotaxy Syndrome	Associate	26111189
Hippocampal Sclerosis	Associate	36191742
Infections	Associate	21169917
Inflammation	Stimulate	24549785
Inflammation	Associate	32271446
KBG syndrome	Associate	32030560
Klatskin Tumor	Associate	26972709
Leukemia	Associate	36595475
Leukemia Lymphocytic Chronic B Cell	Associate	14973184
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	37864206
Leukemia Myeloid Acute	Associate	17767013
Leukemia Prolymphocytic T Cell	Associate	27651098
Leukoplakia Oral	Associate	17922924
Lung Neoplasms	Stimulate	29565490
Lymphoma Mantle Cell	Associate	18787224, 34633777
Mental Disorders	Associate	31504236
Neoplasm Metastasis	Inhibit	30651373
Neoplasms	Stimulate	18313787
Neoplasms	Associate	18577996
Neoplasms	Inhibit	24549785
Orofacial Cleft 1	Associate	26505415
Osteoarthritis	Associate	31155960
Otofaciocervical Syndrome	Associate	35191549
Parkinson Disease	Associate	21812969, 28586827, 31504236
Periapical Periodontitis	Associate	31831777
Polycystic Ovary Syndrome	Associate	29510649
Precancerous Conditions	Associate	34275925
Retinal Dysplasia	Associate	17922924
Schizophrenia	Associate	31504236
Stomach Neoplasms	Stimulate	34275925
Triple Negative Breast Neoplasms	Associate	21152100
Tuberculosis Pulmonary	Associate	21169917
Uniparental Disomy	Associate	21152100

WNT3 (Wnt family member 3)