Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7471
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT1
Synonyms (NCBI Gene) Gene synonyms aliases
BMND16, INT1, OI15
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OI15
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs387907358 G>T Uncertain-significance, pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001231 hsa-miR-34a-5p Luciferase reporter assay 19336450
MIRT001231 hsa-miR-34a-5p Luciferase reporter assay 19336450
MIRT001231 hsa-miR-34a-5p Luciferase reporter assay 19336450
MIRT001231 hsa-miR-34a-5p Flow, Immunoblot, Luciferase reporter assay, Microarray, qRT-PCR 19398721
MIRT005718 hsa-let-7e-5p Flow, Immunoblot, Luciferase reporter assay, Microarray, qRT-PCR 19398721
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000578 Process Embryonic axis specification ISS
GO:0001658 Process Branching involved in ureteric bud morphogenesis IEA
GO:0001934 Process Positive regulation of protein phosphorylation IEA
GO:0005109 Function Frizzled binding IBA 21873635
GO:0005109 Function Frizzled binding IC 19756656
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164820 12774 ENSG00000125084
Protein
UniProt ID P04628
Protein name Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog)
Protein function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:23656646, PubMed:26902720,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 60 370 wnt family Family
Sequence
Sequence length 370
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Chemical carcinogenesis - receptor activation
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
PCP/CE pathway
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Osteogenesis imperfecta Osteogenesis Imperfecta, Osteogenesis imperfecta type III (disorder), Osteogenesis imperfecta type IV (disorder), OSTEOGENESIS IMPERFECTA, TYPE XV, Osteogenesis imperfecta type 3, Osteogenesis imperfecta type 4 rs72659351, rs72659354, rs72659348, rs72659355, rs137853952, rs118203996, rs137853890, rs72659360, rs72659362, rs72659359, rs72659361, rs72659357, rs121918002, rs121918007, rs121918009
View all (530 more)
2349931, 23499309, 23499310, 25046257, 23434763, 28528193, 23656646
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Juvenile osteoporosis, Post-Traumatic Osteoporosis, Idiopathic juvenile osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 23499309, 23656646
Schizencephaly Schizencephaly rs2133969658, rs1564751655, rs1411887961, rs755549724, rs387906867
Scoliosis Scoliosis, unspecified rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Unknown
Disease term Disease name Evidence References Source
Osteogenesis Imperfecta osteogenesis imperfecta type 3, osteogenesis imperfecta type 4, osteogenesis imperfecta type 15 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 18399550
Adenoma Pleomorphic Associate 25076852
Adrenal Cortex Neoplasms Associate 32522271
Amyotrophic Lateral Sclerosis Inhibit 25811776
Arthritis Rheumatoid Associate 10688908, 12428226
Arthropathy progressive pseudorheumatoid of childhood Associate 29246200
Autism Spectrum Disorder Associate 24002087
Bone Diseases Associate 27005318, 30447692
Bone Diseases Metabolic Associate 31968132, 33716164
Brain Diseases Associate 30012084