Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7442
Gene name Gene Name - the full gene name approved by the HGNC.	Transient receptor potential cation channel subfamily V member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRPV1
Synonyms (NCBI Gene) Gene synonyms aliases	VR1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a r

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024445	hsa-miR-215-5p	Microarray	19074876
MIRT026638	hsa-miR-192-5p	Microarray	19074876
MIRT051594	hsa-let-7e-5p	CLASH	23622248
MIRT1457805	hsa-miR-1178	CLIP-seq
MIRT1457806	hsa-miR-1227	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457808	hsa-miR-1253	CLIP-seq
MIRT1457809	hsa-miR-1262	CLIP-seq
MIRT1457810	hsa-miR-1273g	CLIP-seq
MIRT1457811	hsa-miR-1909	CLIP-seq
MIRT1457812	hsa-miR-217	CLIP-seq
MIRT1457813	hsa-miR-2467-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457821	hsa-miR-3911	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457824	hsa-miR-3934	CLIP-seq
MIRT1457825	hsa-miR-4252	CLIP-seq
MIRT1457826	hsa-miR-4270	CLIP-seq
MIRT1457827	hsa-miR-4284	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457829	hsa-miR-4441	CLIP-seq
MIRT1457830	hsa-miR-4443	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457832	hsa-miR-4473	CLIP-seq
MIRT1457833	hsa-miR-450b-3p	CLIP-seq
MIRT1457834	hsa-miR-4695-5p	CLIP-seq
MIRT1457835	hsa-miR-4701-3p	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457838	hsa-miR-4764-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457841	hsa-miR-512-3p	CLIP-seq
MIRT1457842	hsa-miR-520f	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457849	hsa-miR-658	CLIP-seq
MIRT1457850	hsa-miR-665	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457852	hsa-miR-769-3p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457854	hsa-miR-1343	CLIP-seq
MIRT1457855	hsa-miR-3074-5p	CLIP-seq
MIRT1457856	hsa-miR-378g	CLIP-seq
MIRT1457857	hsa-miR-4699-3p	CLIP-seq
MIRT1457858	hsa-miR-4729	CLIP-seq
MIRT1457859	hsa-miR-579	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2137348	hsa-miR-1285	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT2137350	hsa-miR-564	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT2137351	hsa-miR-766	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457827	hsa-miR-4284	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT1457816	hsa-miR-342-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2462459	hsa-miR-186	CLIP-seq
MIRT2462460	hsa-miR-3120-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT2462461	hsa-miR-3613-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT2462462	hsa-miR-371-5p	CLIP-seq
MIRT2462463	hsa-miR-371b-5p	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT2462464	hsa-miR-4778-5p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq
MIRT1457807	hsa-miR-1228	CLIP-seq
MIRT2462459	hsa-miR-186	CLIP-seq
MIRT2462460	hsa-miR-3120-5p	CLIP-seq
MIRT1457814	hsa-miR-3122	CLIP-seq
MIRT2651543	hsa-miR-3163	CLIP-seq
MIRT1457815	hsa-miR-335	CLIP-seq
MIRT2462461	hsa-miR-3613-3p	CLIP-seq
MIRT1457817	hsa-miR-3622a-3p	CLIP-seq
MIRT1457818	hsa-miR-3622b-3p	CLIP-seq
MIRT1457819	hsa-miR-3689a-3p	CLIP-seq
MIRT1457820	hsa-miR-3689c	CLIP-seq
MIRT2462462	hsa-miR-371-5p	CLIP-seq
MIRT2462463	hsa-miR-371b-5p	CLIP-seq
MIRT1457822	hsa-miR-3913-5p	CLIP-seq
MIRT1457823	hsa-miR-3926	CLIP-seq
MIRT1457828	hsa-miR-4433	CLIP-seq
MIRT1457831	hsa-miR-4459	CLIP-seq
MIRT1457836	hsa-miR-4728-5p	CLIP-seq
MIRT1457837	hsa-miR-4747-5p	CLIP-seq
MIRT1457839	hsa-miR-4768-3p	CLIP-seq
MIRT2462464	hsa-miR-4778-5p	CLIP-seq
MIRT1457840	hsa-miR-4786-5p	CLIP-seq
MIRT1457843	hsa-miR-541	CLIP-seq
MIRT1457844	hsa-miR-544b	CLIP-seq
MIRT1457845	hsa-miR-548c-3p	CLIP-seq
MIRT1457846	hsa-miR-548s	CLIP-seq
MIRT1457847	hsa-miR-550a	CLIP-seq
MIRT2137350	hsa-miR-564	CLIP-seq
MIRT1457848	hsa-miR-654-5p	CLIP-seq
MIRT1457851	hsa-miR-671-5p	CLIP-seq
MIRT1457853	hsa-miR-890	CLIP-seq
MIRT2137349	hsa-miR-4738-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001659	Process	Temperature homeostasis	IEA
GO:0001660	Process	Fever generation	IEA
GO:0002024	Process	Diet induced thermogenesis	IEA
GO:0002790	Process	Peptide secretion	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	ISS
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IDA	11226139
GO:0005231	Function	Excitatory extracellular ligand-gated monoatomic ion channel activity	ISS
GO:0005245	Function	Voltage-gated calcium channel activity	TAS
GO:0005262	Function	Calcium channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	TAS	9349813
GO:0005515	Function	Protein binding	IPI	29656858
GO:0005516	Function	Calmodulin binding	IEA
GO:0005516	Function	Calmodulin binding	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	9349813
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9349813
GO:0007635	Process	Chemosensory behavior	TAS	9349813
GO:0009268	Process	Response to pH	IEA
GO:0009408	Process	Response to heat	IEA
GO:0014832	Process	Urinary bladder smooth muscle contraction	IEA
GO:0015278	Function	Intracellularly gated calcium channel activity	ISS
GO:0016020	Component	Membrane	IDA	10201375
GO:0016020	Component	Membrane	IEA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0032591	Component	Dendritic spine membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034605	Process	Cellular response to heat	IDA	11226139
GO:0035091	Function	Phosphatidylinositol binding	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048265	Process	Response to pain	IEA
GO:0048266	Process	Behavioral response to pain	IEA
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050954	Process	Sensory perception of mechanical stimulus	IEA
GO:0050955	Process	Thermoception	IDA	10201375
GO:0050960	Process	Detection of temperature stimulus involved in thermoception	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0050968	Process	Detection of chemical stimulus involved in sensory perception of pain	IEA
GO:0051219	Function	Phosphoprotein binding	IPI	19801576
GO:0051289	Process	Protein homotetramerization	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0060079	Process	Excitatory postsynaptic potential	IEA
GO:0060083	Process	Smooth muscle contraction involved in micturition	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	ISS
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0071312	Process	Cellular response to alkaloid	ISS
GO:0071318	Process	Cellular response to ATP	ISS
GO:0071468	Process	Cellular response to acidic pH	IDA	11226139
GO:0097603	Function	Temperature-gated ion channel activity	IEA
GO:0098703	Process	Calcium ion import across plasma membrane	IBA
GO:0098703	Process	Calcium ion import across plasma membrane	IDA	11226139
GO:0098982	Component	GABA-ergic synapse	IEA
GO:1901594	Process	Response to capsazepine	IMP	11226139
GO:1901594	Process	Response to capsazepine	ISS
GO:1902656	Process	Calcium ion import into cytosol	IEA

MIM	HGNC	e!Ensembl
602076	12716	ENSG00000196689

Protein

UniProt ID

Q8NER1

Protein name

Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)

Protein function

Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular

PDB

6L93 , 8GF8 , 8GF9 , 8GFA , 8JQR , 8X94 , 8YCP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	118 → 232	Ankyrin repeats (3 copies)	Repeat
PF00520	Ion_trans	432 → 695	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum o

Sequence

MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK

Sequence length

839

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Inflammatory mediator regulation of TRP channels		TRP channels

TRPV1 (transient receptor potential cation channel subfamily V member 1)