Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7442
Gene name Gene Name - the full gene name approved by the HGNC.
Transient receptor potential cation channel subfamily V member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRPV1
Synonyms (NCBI Gene) Gene synonyms aliases
VR1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a r
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024445 hsa-miR-215-5p Microarray 19074876
MIRT026638 hsa-miR-192-5p Microarray 19074876
MIRT051594 hsa-let-7e-5p CLASH 23622248
MIRT1457805 hsa-miR-1178 CLIP-seq
MIRT1457806 hsa-miR-1227 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity ISS
GO:0005216 Function Ion channel activity IBA 21873635
GO:0005230 Function Extracellular ligand-gated ion channel activity IDA 11226139
GO:0005231 Function Excitatory extracellular ligand-gated ion channel activity ISS
GO:0005262 Function Calcium channel activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602076 12716 ENSG00000196689
Protein
UniProt ID Q8NER1
Protein name Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)
Protein function Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular
PDB 6L93 , 8GF8 , 8GF9 , 8GFA , 8JQR , 8X94 , 8YCP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 118 232 Ankyrin repeats (3 copies) Repeat
PF00520 Ion_trans 432 695 Ion transport protein Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum o
Sequence
MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA
HGDFFKKT
KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
IILLLAYVILTYILLLNMLIALMGETVNKIAQESK
NIWKLQRAITILDTEKSFLKCMRKA
FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Sequence length 839
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
  TRP channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)
20144892
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
17347480
Unknown
Disease term Disease name Evidence References Source
Atherosclerosis Atherosclerosis 21908651 ClinVar
Pancreatitis Pancreatitis 17698068 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Injuries Associate 19056576
Abdominal Pain Associate 18252749, 34472640
Acne Vulgaris Associate 18769453
Airway Obstruction Associate 33787326
Alzheimer Disease Associate 36065437
Asthma Associate 20639579, 22242698, 27758864, 33787326, 36847817
Atrial Fibrillation Associate 28839241, 33062700
beta Thalassemia Associate 25216685
Bone Diseases Associate 31701920, 35472140, 35862357
Bone Diseases Metabolic Associate 25216685