Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	744
Gene name Gene Name - the full gene name approved by the HGNC.	Metallophosphoesterase domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MPPED2
Synonyms (NCBI Gene) Gene synonyms aliases	239FB, C11orf8
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p14.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Show/Hide all(260)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017152	hsa-miR-335-5p	Microarray	18185580
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT1156653	hsa-miR-1273g	CLIP-seq
MIRT1156654	hsa-miR-1322	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1156656	hsa-miR-2117	CLIP-seq
MIRT1156657	hsa-miR-3119	CLIP-seq
MIRT1156658	hsa-miR-3194-5p	CLIP-seq
MIRT1156659	hsa-miR-323-5p	CLIP-seq
MIRT1156660	hsa-miR-3689d	CLIP-seq
MIRT1156661	hsa-miR-3945	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1156663	hsa-miR-4253	CLIP-seq
MIRT1156664	hsa-miR-4270	CLIP-seq
MIRT1156665	hsa-miR-4273	CLIP-seq
MIRT1156666	hsa-miR-4281	CLIP-seq
MIRT1156667	hsa-miR-4441	CLIP-seq
MIRT1156668	hsa-miR-4491	CLIP-seq
MIRT1156669	hsa-miR-4493	CLIP-seq
MIRT1156670	hsa-miR-4646-5p	CLIP-seq
MIRT1156671	hsa-miR-4657	CLIP-seq
MIRT1156672	hsa-miR-4731-5p	CLIP-seq
MIRT1156673	hsa-miR-4747-5p	CLIP-seq
MIRT1156674	hsa-miR-4753-3p	CLIP-seq
MIRT1156675	hsa-miR-4778-5p	CLIP-seq
MIRT1156676	hsa-miR-543	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1156678	hsa-miR-1251	CLIP-seq
MIRT1156679	hsa-miR-1264	CLIP-seq
MIRT1156680	hsa-miR-1273c	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1156682	hsa-miR-1284	CLIP-seq
MIRT1156683	hsa-miR-1302	CLIP-seq
MIRT1156684	hsa-miR-130a	CLIP-seq
MIRT1156685	hsa-miR-130b	CLIP-seq
MIRT1156686	hsa-miR-148a	CLIP-seq
MIRT1156687	hsa-miR-148b	CLIP-seq
MIRT1156688	hsa-miR-152	CLIP-seq
MIRT1156689	hsa-miR-19a	CLIP-seq
MIRT1156690	hsa-miR-19b	CLIP-seq
MIRT1156691	hsa-miR-2113	CLIP-seq
MIRT1156692	hsa-miR-218	CLIP-seq
MIRT1156693	hsa-miR-2276	CLIP-seq
MIRT1156694	hsa-miR-301a	CLIP-seq
MIRT1156695	hsa-miR-301b	CLIP-seq
MIRT1156696	hsa-miR-3122	CLIP-seq
MIRT1156697	hsa-miR-3125	CLIP-seq
MIRT1156698	hsa-miR-3163	CLIP-seq
MIRT1156699	hsa-miR-3175	CLIP-seq
MIRT1156700	hsa-miR-324-5p	CLIP-seq
MIRT1156701	hsa-miR-338-5p	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT1156703	hsa-miR-3653	CLIP-seq
MIRT1156704	hsa-miR-3666	CLIP-seq
MIRT1156705	hsa-miR-3913-5p	CLIP-seq
MIRT1156706	hsa-miR-3916	CLIP-seq
MIRT1156707	hsa-miR-4295	CLIP-seq
MIRT1156708	hsa-miR-4298	CLIP-seq
MIRT1156709	hsa-miR-454	CLIP-seq
MIRT1156710	hsa-miR-4670-5p	CLIP-seq
MIRT1156711	hsa-miR-4698	CLIP-seq
MIRT1156712	hsa-miR-4699-5p	CLIP-seq
MIRT1156713	hsa-miR-4762-5p	CLIP-seq
MIRT1156714	hsa-miR-4772-3p	CLIP-seq
MIRT1156715	hsa-miR-4796-5p	CLIP-seq
MIRT1156716	hsa-miR-549	CLIP-seq
MIRT1156717	hsa-miR-579	CLIP-seq
MIRT1156718	hsa-miR-599	CLIP-seq
MIRT1156719	hsa-miR-607	CLIP-seq
MIRT1156720	hsa-miR-621	CLIP-seq
MIRT1156672	hsa-miR-4731-5p	CLIP-seq
MIRT1922241	hsa-miR-1193	CLIP-seq
MIRT1922242	hsa-miR-197	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1922243	hsa-miR-2392	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1922245	hsa-miR-3187-3p	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT1922247	hsa-miR-4435	CLIP-seq
MIRT1922248	hsa-miR-4701-5p	CLIP-seq
MIRT1922249	hsa-miR-4716-5p	CLIP-seq
MIRT1922250	hsa-miR-4781-3p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT1922252	hsa-miR-5096	CLIP-seq
MIRT1922253	hsa-miR-548s	CLIP-seq
MIRT1922254	hsa-miR-588	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1922241	hsa-miR-1193	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1922242	hsa-miR-197	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1922243	hsa-miR-2392	CLIP-seq
MIRT1922848	hsa-miR-3127-5p	CLIP-seq
MIRT1922245	hsa-miR-3187-3p	CLIP-seq
MIRT1922849	hsa-miR-3665	CLIP-seq
MIRT1922247	hsa-miR-4435	CLIP-seq
MIRT1922850	hsa-miR-4688	CLIP-seq
MIRT1922248	hsa-miR-4701-5p	CLIP-seq
MIRT1922249	hsa-miR-4716-5p	CLIP-seq
MIRT1922851	hsa-miR-4736	CLIP-seq
MIRT1922250	hsa-miR-4781-3p	CLIP-seq
MIRT1922852	hsa-miR-486-3p	CLIP-seq
MIRT1922853	hsa-miR-515-3p	CLIP-seq
MIRT1922854	hsa-miR-519e	CLIP-seq
MIRT1922253	hsa-miR-548s	CLIP-seq
MIRT1922254	hsa-miR-588	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1922855	hsa-miR-764	CLIP-seq
MIRT2044855	hsa-miR-4310	CLIP-seq
MIRT1156678	hsa-miR-1251	CLIP-seq
MIRT1156679	hsa-miR-1264	CLIP-seq
MIRT1156680	hsa-miR-1273c	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1156682	hsa-miR-1284	CLIP-seq
MIRT1156684	hsa-miR-130a	CLIP-seq
MIRT1156685	hsa-miR-130b	CLIP-seq
MIRT1156686	hsa-miR-148a	CLIP-seq
MIRT1156687	hsa-miR-148b	CLIP-seq
MIRT1156688	hsa-miR-152	CLIP-seq
MIRT2274082	hsa-miR-188-5p	CLIP-seq
MIRT1156689	hsa-miR-19a	CLIP-seq
MIRT1156690	hsa-miR-19b	CLIP-seq
MIRT2274083	hsa-miR-204	CLIP-seq
MIRT2274084	hsa-miR-211	CLIP-seq
MIRT1156691	hsa-miR-2113	CLIP-seq
MIRT2274085	hsa-miR-2115	CLIP-seq
MIRT1156692	hsa-miR-218	CLIP-seq
MIRT1156694	hsa-miR-301a	CLIP-seq
MIRT1156695	hsa-miR-301b	CLIP-seq
MIRT2274086	hsa-miR-3120-3p	CLIP-seq
MIRT2274087	hsa-miR-3121-5p	CLIP-seq
MIRT2274088	hsa-miR-3153	CLIP-seq
MIRT1156700	hsa-miR-324-5p	CLIP-seq
MIRT1156701	hsa-miR-338-5p	CLIP-seq
MIRT1156703	hsa-miR-3653	CLIP-seq
MIRT1156704	hsa-miR-3666	CLIP-seq
MIRT2274089	hsa-miR-3667-3p	CLIP-seq
MIRT1156707	hsa-miR-4295	CLIP-seq
MIRT2044855	hsa-miR-4310	CLIP-seq
MIRT2274090	hsa-miR-4453	CLIP-seq
MIRT2274091	hsa-miR-4502	CLIP-seq
MIRT2274092	hsa-miR-4538	CLIP-seq
MIRT1156709	hsa-miR-454	CLIP-seq
MIRT2274093	hsa-miR-4667-3p	CLIP-seq
MIRT2274094	hsa-miR-4668-5p	CLIP-seq
MIRT1156710	hsa-miR-4670-5p	CLIP-seq
MIRT2274095	hsa-miR-4687-3p	CLIP-seq
MIRT1156712	hsa-miR-4699-5p	CLIP-seq
MIRT2274096	hsa-miR-4762-3p	CLIP-seq
MIRT1156715	hsa-miR-4796-5p	CLIP-seq
MIRT2274097	hsa-miR-520d-5p	CLIP-seq
MIRT2274098	hsa-miR-524-5p	CLIP-seq
MIRT2274099	hsa-miR-570	CLIP-seq
MIRT1156717	hsa-miR-579	CLIP-seq
MIRT1156720	hsa-miR-621	CLIP-seq
MIRT2274100	hsa-miR-647	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454405	hsa-miR-1224-3p	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454407	hsa-miR-1291	CLIP-seq
MIRT2454408	hsa-miR-1304	CLIP-seq
MIRT2454409	hsa-miR-193a-3p	CLIP-seq
MIRT2454410	hsa-miR-193b	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT2454413	hsa-miR-328	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454420	hsa-miR-4758-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2454423	hsa-miR-491-3p	CLIP-seq
MIRT2454424	hsa-miR-501-3p	CLIP-seq
MIRT2454425	hsa-miR-502-3p	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2454427	hsa-miR-663b	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2572899	hsa-miR-1827	CLIP-seq
MIRT2572900	hsa-miR-187	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2572901	hsa-miR-421	CLIP-seq
MIRT2572902	hsa-miR-4269	CLIP-seq
MIRT2572903	hsa-miR-4276	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2572904	hsa-miR-4691-3p	CLIP-seq
MIRT2572905	hsa-miR-4709-5p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2572906	hsa-miR-505	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2572907	hsa-miR-626	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2572901	hsa-miR-421	CLIP-seq
MIRT2572902	hsa-miR-4269	CLIP-seq
MIRT2572903	hsa-miR-4276	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2572905	hsa-miR-4709-5p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2572906	hsa-miR-505	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2572907	hsa-miR-626	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	19060904, 25416956, 32296183
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	ISS
GO:0016208	Function	AMP binding	IEA
GO:0016208	Function	AMP binding	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019002	Function	GMP binding	IEA
GO:0019002	Function	GMP binding	ISS
GO:0030145	Function	Manganese ion binding	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
600911	1180	ENSG00000066382

Protein

UniProt ID

Q15777

Protein name

Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)

Protein function

Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00149	Metallophos	58 → 256	Calcineurin-like phosphoesterase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in fetal brain.

Sequence

MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRF
VCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHEL
TFDKEFMADLVKQDYYRFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWT
PWFNGWGFNLPRGQSLLDKWNLIPEGIDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQ
RRVRPKLHVFGGIHEGYGIMTDGYTTYINASTCTVSFQPTNPPIIFDLPNPQGS

Sequence length

294

Interactions

View interactions

Show/Hide Unknown Diseases (9)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Dental caries	Dental caries	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Gout	Gout	N/A	N/A	GWAS
Hypertension	Hypertension (PheCode 401), Essential hypertension (PheCode 401.1), High blood pressure / hypertension	N/A	N/A	GWAS
Kidney Disease	Chronic kidney disease	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Associate	30846004
Colorectal Neoplasms	Associate	30846004
Dental Caries	Associate	21940522, 24556642, 24810274
Glioblastoma	Inhibit	33734003
Neoplasms	Inhibit	33734003
Polyps	Associate	30846004
Salivary Gland Diseases	Associate	25985088
Thyroid Cancer Papillary	Associate	17914110
Uterine Cervical Neoplasms	Associate	26417997

MPPED2 (metallophosphoesterase domain containing 2)