MPPED2 (metallophosphoesterase domain containing 2)

Gene

• Entrez ID: 744
• Gene name: Metallophosphoesterase domain containing 2
• Gene symbol: MPPED2
• Synonyms (NCBI Gene): 239FB, C11orf8
• Chromosome: 11
• Chromosome location: 11p14.1
• Summary: This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017152	hsa-miR-335-5p	Microarray	18185580
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT732399	hsa-miR-448	Luciferase reporter assay, qRT-PCR, Western blot	27698780
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT1156653	hsa-miR-1273g	CLIP-seq
MIRT1156654	hsa-miR-1322	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1156656	hsa-miR-2117	CLIP-seq
MIRT1156657	hsa-miR-3119	CLIP-seq
MIRT1156658	hsa-miR-3194-5p	CLIP-seq
MIRT1156659	hsa-miR-323-5p	CLIP-seq
MIRT1156660	hsa-miR-3689d	CLIP-seq
MIRT1156661	hsa-miR-3945	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1156663	hsa-miR-4253	CLIP-seq
MIRT1156664	hsa-miR-4270	CLIP-seq
MIRT1156665	hsa-miR-4273	CLIP-seq
MIRT1156666	hsa-miR-4281	CLIP-seq
MIRT1156667	hsa-miR-4441	CLIP-seq
MIRT1156668	hsa-miR-4491	CLIP-seq
MIRT1156669	hsa-miR-4493	CLIP-seq
MIRT1156670	hsa-miR-4646-5p	CLIP-seq
MIRT1156671	hsa-miR-4657	CLIP-seq
MIRT1156672	hsa-miR-4731-5p	CLIP-seq
MIRT1156673	hsa-miR-4747-5p	CLIP-seq
MIRT1156674	hsa-miR-4753-3p	CLIP-seq
MIRT1156675	hsa-miR-4778-5p	CLIP-seq
MIRT1156676	hsa-miR-543	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1156678	hsa-miR-1251	CLIP-seq
MIRT1156679	hsa-miR-1264	CLIP-seq
MIRT1156680	hsa-miR-1273c	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1156682	hsa-miR-1284	CLIP-seq
MIRT1156683	hsa-miR-1302	CLIP-seq
MIRT1156684	hsa-miR-130a	CLIP-seq
MIRT1156685	hsa-miR-130b	CLIP-seq
MIRT1156686	hsa-miR-148a	CLIP-seq
MIRT1156687	hsa-miR-148b	CLIP-seq
MIRT1156688	hsa-miR-152	CLIP-seq
MIRT1156689	hsa-miR-19a	CLIP-seq
MIRT1156690	hsa-miR-19b	CLIP-seq
MIRT1156691	hsa-miR-2113	CLIP-seq
MIRT1156692	hsa-miR-218	CLIP-seq
MIRT1156693	hsa-miR-2276	CLIP-seq
MIRT1156694	hsa-miR-301a	CLIP-seq
MIRT1156695	hsa-miR-301b	CLIP-seq
MIRT1156696	hsa-miR-3122	CLIP-seq
MIRT1156697	hsa-miR-3125	CLIP-seq
MIRT1156698	hsa-miR-3163	CLIP-seq
MIRT1156699	hsa-miR-3175	CLIP-seq
MIRT1156700	hsa-miR-324-5p	CLIP-seq
MIRT1156701	hsa-miR-338-5p	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT1156703	hsa-miR-3653	CLIP-seq
MIRT1156704	hsa-miR-3666	CLIP-seq
MIRT1156705	hsa-miR-3913-5p	CLIP-seq
MIRT1156706	hsa-miR-3916	CLIP-seq
MIRT1156707	hsa-miR-4295	CLIP-seq
MIRT1156708	hsa-miR-4298	CLIP-seq
MIRT1156709	hsa-miR-454	CLIP-seq
MIRT1156710	hsa-miR-4670-5p	CLIP-seq
MIRT1156711	hsa-miR-4698	CLIP-seq
MIRT1156712	hsa-miR-4699-5p	CLIP-seq
MIRT1156713	hsa-miR-4762-5p	CLIP-seq
MIRT1156714	hsa-miR-4772-3p	CLIP-seq
MIRT1156715	hsa-miR-4796-5p	CLIP-seq
MIRT1156716	hsa-miR-549	CLIP-seq
MIRT1156717	hsa-miR-579	CLIP-seq
MIRT1156718	hsa-miR-599	CLIP-seq
MIRT1156719	hsa-miR-607	CLIP-seq
MIRT1156720	hsa-miR-621	CLIP-seq
MIRT1156672	hsa-miR-4731-5p	CLIP-seq
MIRT1922241	hsa-miR-1193	CLIP-seq
MIRT1922242	hsa-miR-197	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1922243	hsa-miR-2392	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1922245	hsa-miR-3187-3p	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT1922247	hsa-miR-4435	CLIP-seq
MIRT1922248	hsa-miR-4701-5p	CLIP-seq
MIRT1922249	hsa-miR-4716-5p	CLIP-seq
MIRT1922250	hsa-miR-4781-3p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT1922252	hsa-miR-5096	CLIP-seq
MIRT1922253	hsa-miR-548s	CLIP-seq
MIRT1922254	hsa-miR-588	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1922241	hsa-miR-1193	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1922242	hsa-miR-197	CLIP-seq
MIRT1156655	hsa-miR-1976	CLIP-seq
MIRT1922243	hsa-miR-2392	CLIP-seq
MIRT1922848	hsa-miR-3127-5p	CLIP-seq
MIRT1922245	hsa-miR-3187-3p	CLIP-seq
MIRT1922849	hsa-miR-3665	CLIP-seq
MIRT1922247	hsa-miR-4435	CLIP-seq
MIRT1922850	hsa-miR-4688	CLIP-seq
MIRT1922248	hsa-miR-4701-5p	CLIP-seq
MIRT1922249	hsa-miR-4716-5p	CLIP-seq
MIRT1922851	hsa-miR-4736	CLIP-seq
MIRT1922250	hsa-miR-4781-3p	CLIP-seq
MIRT1922852	hsa-miR-486-3p	CLIP-seq
MIRT1922853	hsa-miR-515-3p	CLIP-seq
MIRT1922854	hsa-miR-519e	CLIP-seq
MIRT1922253	hsa-miR-548s	CLIP-seq
MIRT1922254	hsa-miR-588	CLIP-seq
MIRT1156677	hsa-miR-640	CLIP-seq
MIRT1922855	hsa-miR-764	CLIP-seq
MIRT2044855	hsa-miR-4310	CLIP-seq
MIRT1156678	hsa-miR-1251	CLIP-seq
MIRT1156679	hsa-miR-1264	CLIP-seq
MIRT1156680	hsa-miR-1273c	CLIP-seq
MIRT1156681	hsa-miR-128	CLIP-seq
MIRT1156682	hsa-miR-1284	CLIP-seq
MIRT1156684	hsa-miR-130a	CLIP-seq
MIRT1156685	hsa-miR-130b	CLIP-seq
MIRT1156686	hsa-miR-148a	CLIP-seq
MIRT1156687	hsa-miR-148b	CLIP-seq
MIRT1156688	hsa-miR-152	CLIP-seq
MIRT2274082	hsa-miR-188-5p	CLIP-seq
MIRT1156689	hsa-miR-19a	CLIP-seq
MIRT1156690	hsa-miR-19b	CLIP-seq
MIRT2274083	hsa-miR-204	CLIP-seq
MIRT2274084	hsa-miR-211	CLIP-seq
MIRT1156691	hsa-miR-2113	CLIP-seq
MIRT2274085	hsa-miR-2115	CLIP-seq
MIRT1156692	hsa-miR-218	CLIP-seq
MIRT1156694	hsa-miR-301a	CLIP-seq
MIRT1156695	hsa-miR-301b	CLIP-seq
MIRT2274086	hsa-miR-3120-3p	CLIP-seq
MIRT2274087	hsa-miR-3121-5p	CLIP-seq
MIRT2274088	hsa-miR-3153	CLIP-seq
MIRT1156700	hsa-miR-324-5p	CLIP-seq
MIRT1156701	hsa-miR-338-5p	CLIP-seq
MIRT1156703	hsa-miR-3653	CLIP-seq
MIRT1156704	hsa-miR-3666	CLIP-seq
MIRT2274089	hsa-miR-3667-3p	CLIP-seq
MIRT1156707	hsa-miR-4295	CLIP-seq
MIRT2044855	hsa-miR-4310	CLIP-seq
MIRT2274090	hsa-miR-4453	CLIP-seq
MIRT2274091	hsa-miR-4502	CLIP-seq
MIRT2274092	hsa-miR-4538	CLIP-seq
MIRT1156709	hsa-miR-454	CLIP-seq
MIRT2274093	hsa-miR-4667-3p	CLIP-seq
MIRT2274094	hsa-miR-4668-5p	CLIP-seq
MIRT1156710	hsa-miR-4670-5p	CLIP-seq
MIRT2274095	hsa-miR-4687-3p	CLIP-seq
MIRT1156712	hsa-miR-4699-5p	CLIP-seq
MIRT2274096	hsa-miR-4762-3p	CLIP-seq
MIRT1156715	hsa-miR-4796-5p	CLIP-seq
MIRT2274097	hsa-miR-520d-5p	CLIP-seq
MIRT2274098	hsa-miR-524-5p	CLIP-seq
MIRT2274099	hsa-miR-570	CLIP-seq
MIRT1156717	hsa-miR-579	CLIP-seq
MIRT1156720	hsa-miR-621	CLIP-seq
MIRT2274100	hsa-miR-647	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454405	hsa-miR-1224-3p	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454407	hsa-miR-1291	CLIP-seq
MIRT2454408	hsa-miR-1304	CLIP-seq
MIRT2454409	hsa-miR-193a-3p	CLIP-seq
MIRT2454410	hsa-miR-193b	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT2454413	hsa-miR-328	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454420	hsa-miR-4758-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2454423	hsa-miR-491-3p	CLIP-seq
MIRT2454424	hsa-miR-501-3p	CLIP-seq
MIRT2454425	hsa-miR-502-3p	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2454427	hsa-miR-663b	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2572899	hsa-miR-1827	CLIP-seq
MIRT2572900	hsa-miR-187	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2572901	hsa-miR-421	CLIP-seq
MIRT2572902	hsa-miR-4269	CLIP-seq
MIRT2572903	hsa-miR-4276	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2572904	hsa-miR-4691-3p	CLIP-seq
MIRT2572905	hsa-miR-4709-5p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2572906	hsa-miR-505	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2572907	hsa-miR-626	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq
MIRT1156652	hsa-miR-1202	CLIP-seq
MIRT2454406	hsa-miR-1267	CLIP-seq
MIRT2454411	hsa-miR-3129-3p	CLIP-seq
MIRT2454412	hsa-miR-3135b	CLIP-seq
MIRT1922244	hsa-miR-3149	CLIP-seq
MIRT1156702	hsa-miR-3649	CLIP-seq
MIRT2454414	hsa-miR-3652	CLIP-seq
MIRT1156662	hsa-miR-3972	CLIP-seq
MIRT1922246	hsa-miR-411	CLIP-seq
MIRT2572901	hsa-miR-421	CLIP-seq
MIRT2572902	hsa-miR-4269	CLIP-seq
MIRT2572903	hsa-miR-4276	CLIP-seq
MIRT2454415	hsa-miR-4423-5p	CLIP-seq
MIRT2454416	hsa-miR-4430	CLIP-seq
MIRT2454417	hsa-miR-4653-3p	CLIP-seq
MIRT2572905	hsa-miR-4709-5p	CLIP-seq
MIRT2454418	hsa-miR-4735-5p	CLIP-seq
MIRT2454419	hsa-miR-4755-3p	CLIP-seq
MIRT2454421	hsa-miR-4775	CLIP-seq
MIRT2454422	hsa-miR-4797-5p	CLIP-seq
MIRT1922251	hsa-miR-483-5p	CLIP-seq
MIRT2572906	hsa-miR-505	CLIP-seq
MIRT2454426	hsa-miR-590-3p	CLIP-seq
MIRT2572907	hsa-miR-626	CLIP-seq
MIRT2454428	hsa-miR-720	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	19060904, 25416956, 32296183
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	ISS
GO:0016208	Function	AMP binding	IEA
GO:0016208	Function	AMP binding	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019002	Function	GMP binding	IEA
GO:0019002	Function	GMP binding	ISS
GO:0030145	Function	Manganese ion binding	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 600911
• HGNC: 1180
• e!Ensembl: ENSG00000066382

Protein

• UniProt ID: Q15777
• Protein name: Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)
• Protein function: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00149	Metallophos	58 → 256	Calcineurin-like phosphoesterase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in fetal brain.
• Sequence:

  MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRF
  VCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHEL
  TFDKEFMADLVKQDYYRFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWT
  PWFNGWGFNLPRGQSLLDKWNLIPEGIDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQ
  RRVRPKLHVFGGIHEGYGIMTDGYTTYINASTCTVSFQPTNPPIIFDLPNPQGS

• Sequence length: 294