Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7436
Gene name	Very low density lipoprotein receptor
Gene symbol	VLDLR
Synonyms (NCBI Gene)	CAMRQ1CARMQ1CHRMQ1VLDL-RVLDLRCH
Chromosome	9
Chromosome location	9p24.2
Summary	The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles

Show/Hide all (14)

SNP ID	Visualize variation	Clinical significance	Consequence
rs80338905	C>A,T	Pathogenic	Coding sequence variant, non coding transcript variant, synonymous variant, stop gained
rs80338906	T>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs80338907	C>A,T	Pathogenic	Coding sequence variant, non coding transcript variant, synonymous variant, stop gained
rs116306908	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, non coding transcript variant, missense variant
rs139671268	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, non coding transcript variant, missense variant
rs140526335	A>G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs141850403	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Synonymous variant, non coding transcript variant, coding sequence variant
rs397514750	G>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs398122380	TACAAGT>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs745973997	G>A	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs755328835	A>G	Likely-pathogenic	Splice acceptor variant
rs770269674	G>A	Pathogenic	Splice acceptor variant
rs1554621211	GAGTG>-	Pathogenic	Inframe indel, non coding transcript variant, coding sequence variant, stop gained
rs1563764078	T>C	Likely-pathogenic	Splice donor variant

365

Show/Hide all (365)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018291	hsa-miR-335-5p	Microarray	18185580
MIRT020261	hsa-miR-130b-3p	Sequencing	20371350
MIRT028137	hsa-miR-93-5p	Sequencing	20371350
MIRT054784	hsa-miR-135a-5p	Luciferase reporter assayqRT-PCRWestern blot	24903309
MIRT713315	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT721847	hsa-miR-4280	HITS-CLIP	19536157
MIRT244826	hsa-miR-1279	HITS-CLIP	19536157
MIRT721846	hsa-miR-5007-3p	HITS-CLIP	19536157
MIRT713314	hsa-miR-3161	HITS-CLIP	19536157
MIRT713313	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT713315	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT244826	hsa-miR-1279	HITS-CLIP	19536157
MIRT713314	hsa-miR-3161	HITS-CLIP	19536157
MIRT713313	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT644815	hsa-miR-4686	HITS-CLIP	23824327
MIRT644816	hsa-miR-6072	HITS-CLIP	23824327
MIRT644814	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644813	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT644812	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT644811	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT644810	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT644809	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT644808	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT644807	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT644806	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT636145	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT630936	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT630936	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT107568	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT533233	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT546056	hsa-miR-4433a-5p	PAR-CLIP	21572407
MIRT107578	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT107574	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT107575	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT107580	hsa-miR-4433b-5p	PAR-CLIP	21572407
MIRT107572	hsa-miR-676-3p	PAR-CLIP	21572407
MIRT107576	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT107573	hsa-miR-4646-3p	PAR-CLIP	21572407
MIRT107571	hsa-miR-2355-3p	PAR-CLIP	21572407
MIRT124632	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT533234	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT533233	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT533232	hsa-miR-5680	PAR-CLIP	22012620
MIRT533231	hsa-miR-3973	PAR-CLIP	22012620
MIRT107536	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT107537	hsa-miR-520h	PAR-CLIP	22012620
MIRT533230	hsa-miR-607	PAR-CLIP	22012620
MIRT533229	hsa-miR-1305	PAR-CLIP	22012620
MIRT443136	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT443135	hsa-miR-548ab	PAR-CLIP	22100165
MIRT443134	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT443133	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT443132	hsa-miR-548ak	PAR-CLIP	22100165
MIRT443131	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT443130	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT443129	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT443128	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT443127	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT443126	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT443125	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT443124	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT443123	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT443122	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT443121	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT443120	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT443119	hsa-miR-548i	PAR-CLIP	22100165
MIRT443118	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT443117	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT443116	hsa-miR-548w	PAR-CLIP	22100165
MIRT443115	hsa-miR-548y	PAR-CLIP	22100165
MIRT443114	hsa-miR-559	PAR-CLIP	22100165
MIRT443113	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT443112	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT443111	hsa-miR-3926	PAR-CLIP	22100165
MIRT443110	hsa-miR-548s	PAR-CLIP	22100165
MIRT439303	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT439302	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT439303	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT439302	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	27418678
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	27418678
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	27418678
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	27418678
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	27418678
MIRT618560	hsa-miR-4312	HITS-CLIP	27418678
MIRT618560	hsa-miR-4312	HITS-CLIP	27418678
MIRT618560	hsa-miR-4312	HITS-CLIP	27418678
MIRT618560	hsa-miR-4312	HITS-CLIP	27418678
MIRT618560	hsa-miR-4312	HITS-CLIP	27418678
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	27418678
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	27418678
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	27418678
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	27418678
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	27418678
MIRT618559	hsa-miR-630	HITS-CLIP	27418678
MIRT618561	hsa-miR-643	HITS-CLIP	27418678
MIRT618561	hsa-miR-643	HITS-CLIP	27418678
MIRT618561	hsa-miR-643	HITS-CLIP	27418678
MIRT618561	hsa-miR-643	HITS-CLIP	27418678
MIRT618561	hsa-miR-643	HITS-CLIP	27418678
MIRT713315	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT721847	hsa-miR-4280	HITS-CLIP	19536157
MIRT244826	hsa-miR-1279	HITS-CLIP	19536157
MIRT721846	hsa-miR-5007-3p	HITS-CLIP	19536157
MIRT713314	hsa-miR-3161	HITS-CLIP	19536157
MIRT713313	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT713315	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT244826	hsa-miR-1279	HITS-CLIP	19536157
MIRT713314	hsa-miR-3161	HITS-CLIP	19536157
MIRT713313	hsa-miR-2681-5p	HITS-CLIP	19536157
MIRT644815	hsa-miR-4686	HITS-CLIP	23824327
MIRT644816	hsa-miR-6072	HITS-CLIP	23824327
MIRT644814	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT644813	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT644812	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT644811	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT644810	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT644809	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT644808	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT644807	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT644806	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT636145	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT630936	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT630936	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT618561	hsa-miR-643	HITS-CLIP	23824327
MIRT618560	hsa-miR-4312	HITS-CLIP	23824327
MIRT618559	hsa-miR-630	HITS-CLIP	23824327
MIRT618558	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT618557	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT107568	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT533233	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT546056	hsa-miR-4433a-5p	PAR-CLIP	21572407
MIRT107578	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT107574	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT107575	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT107580	hsa-miR-4433b-5p	PAR-CLIP	21572407
MIRT107572	hsa-miR-676-3p	PAR-CLIP	21572407
MIRT107576	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT107573	hsa-miR-4646-3p	PAR-CLIP	21572407
MIRT107571	hsa-miR-2355-3p	PAR-CLIP	21572407
MIRT124632	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT533234	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT533233	hsa-miR-338-5p	PAR-CLIP	22012620
MIRT533232	hsa-miR-5680	PAR-CLIP	22012620
MIRT533231	hsa-miR-3973	PAR-CLIP	22012620
MIRT107536	hsa-miR-520g-3p	PAR-CLIP	22012620
MIRT107537	hsa-miR-520h	PAR-CLIP	22012620
MIRT533230	hsa-miR-607	PAR-CLIP	22012620
MIRT533229	hsa-miR-1305	PAR-CLIP	22012620
MIRT443136	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT443135	hsa-miR-548ab	PAR-CLIP	22100165
MIRT443134	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT443133	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT443132	hsa-miR-548ak	PAR-CLIP	22100165
MIRT443131	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT443130	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT443129	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT443128	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT443127	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT443126	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT443125	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT443124	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT443123	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT443122	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT443121	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT443120	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT443119	hsa-miR-548i	PAR-CLIP	22100165
MIRT443118	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT443117	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT443116	hsa-miR-548w	PAR-CLIP	22100165
MIRT443115	hsa-miR-548y	PAR-CLIP	22100165
MIRT443114	hsa-miR-559	PAR-CLIP	22100165
MIRT443113	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT443112	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT443111	hsa-miR-3926	PAR-CLIP	22100165
MIRT443110	hsa-miR-548s	PAR-CLIP	22100165
MIRT755425	hsa-miR-423-3p	Luciferase reporter assayWestern blottingqRT-PCR	36352275
MIRT1485221	hsa-miR-106a	CLIP-seq
MIRT1485222	hsa-miR-106b	CLIP-seq
MIRT1485223	hsa-miR-1287	CLIP-seq
MIRT1485224	hsa-miR-135a	CLIP-seq
MIRT1485225	hsa-miR-135b	CLIP-seq
MIRT1485226	hsa-miR-17	CLIP-seq
MIRT1485227	hsa-miR-20a	CLIP-seq
MIRT1485228	hsa-miR-20b	CLIP-seq
MIRT1485229	hsa-miR-2117	CLIP-seq
MIRT1485230	hsa-miR-3119	CLIP-seq
MIRT1485231	hsa-miR-3135b	CLIP-seq
MIRT1485232	hsa-miR-3145-3p	CLIP-seq
MIRT1485233	hsa-miR-3153	CLIP-seq
MIRT1485234	hsa-miR-3160-5p	CLIP-seq
MIRT1485235	hsa-miR-3187-3p	CLIP-seq
MIRT1485236	hsa-miR-3192	CLIP-seq
MIRT1485237	hsa-miR-320a	CLIP-seq
MIRT1485238	hsa-miR-320b	CLIP-seq
MIRT1485239	hsa-miR-320c	CLIP-seq
MIRT1485240	hsa-miR-320d	CLIP-seq
MIRT1485241	hsa-miR-326	CLIP-seq
MIRT1485242	hsa-miR-330-5p	CLIP-seq
MIRT1485243	hsa-miR-4257	CLIP-seq
MIRT1485244	hsa-miR-4273	CLIP-seq
MIRT1485245	hsa-miR-4314	CLIP-seq
MIRT1485246	hsa-miR-4420	CLIP-seq
MIRT1485247	hsa-miR-4429	CLIP-seq
MIRT1485248	hsa-miR-4435	CLIP-seq
MIRT1485249	hsa-miR-448	CLIP-seq
MIRT1485250	hsa-miR-4646-5p	CLIP-seq
MIRT1485251	hsa-miR-4677-5p	CLIP-seq
MIRT1485252	hsa-miR-4699-3p	CLIP-seq
MIRT1485253	hsa-miR-4701-5p	CLIP-seq
MIRT1485254	hsa-miR-519a	CLIP-seq
MIRT1485255	hsa-miR-519b-3p	CLIP-seq
MIRT1485256	hsa-miR-519c-3p	CLIP-seq
MIRT1485257	hsa-miR-519d	CLIP-seq
MIRT1485258	hsa-miR-588	CLIP-seq
MIRT1485259	hsa-miR-676	CLIP-seq
MIRT1485260	hsa-miR-802	CLIP-seq
MIRT1485261	hsa-miR-93	CLIP-seq
MIRT1485262	hsa-miR-101	CLIP-seq
MIRT1485221	hsa-miR-106a	CLIP-seq
MIRT1485222	hsa-miR-106b	CLIP-seq
MIRT1485263	hsa-miR-1244	CLIP-seq
MIRT1485264	hsa-miR-1271	CLIP-seq
MIRT1485265	hsa-miR-1284	CLIP-seq
MIRT1485223	hsa-miR-1287	CLIP-seq
MIRT1485224	hsa-miR-135a	CLIP-seq
MIRT1485225	hsa-miR-135b	CLIP-seq
MIRT1485266	hsa-miR-144	CLIP-seq
MIRT1485226	hsa-miR-17	CLIP-seq
MIRT1485267	hsa-miR-182	CLIP-seq
MIRT1485268	hsa-miR-199a-3p	CLIP-seq
MIRT1485269	hsa-miR-199b-3p	CLIP-seq
MIRT1485270	hsa-miR-200b	CLIP-seq
MIRT1485271	hsa-miR-200c	CLIP-seq
MIRT1485227	hsa-miR-20a	CLIP-seq
MIRT1485228	hsa-miR-20b	CLIP-seq
MIRT1485229	hsa-miR-2117	CLIP-seq
MIRT1485272	hsa-miR-297	CLIP-seq
MIRT1485273	hsa-miR-300	CLIP-seq
MIRT1485230	hsa-miR-3119	CLIP-seq
MIRT1485274	hsa-miR-3129-5p	CLIP-seq
MIRT1485231	hsa-miR-3135b	CLIP-seq
MIRT1485232	hsa-miR-3145-3p	CLIP-seq
MIRT1485233	hsa-miR-3153	CLIP-seq
MIRT1485234	hsa-miR-3160-5p	CLIP-seq
MIRT1485235	hsa-miR-3187-3p	CLIP-seq
MIRT1485236	hsa-miR-3192	CLIP-seq
MIRT1485241	hsa-miR-326	CLIP-seq
MIRT1485242	hsa-miR-330-5p	CLIP-seq
MIRT1485275	hsa-miR-3688-5p	CLIP-seq
MIRT1485276	hsa-miR-381	CLIP-seq
MIRT1485243	hsa-miR-4257	CLIP-seq
MIRT1485244	hsa-miR-4273	CLIP-seq
MIRT1485277	hsa-miR-429	CLIP-seq
MIRT1485245	hsa-miR-4314	CLIP-seq
MIRT1485246	hsa-miR-4420	CLIP-seq
MIRT1485248	hsa-miR-4435	CLIP-seq
MIRT1485249	hsa-miR-448	CLIP-seq
MIRT1485250	hsa-miR-4646-5p	CLIP-seq
MIRT1485278	hsa-miR-4666-3p	CLIP-seq
MIRT1485251	hsa-miR-4677-5p	CLIP-seq
MIRT1485252	hsa-miR-4699-3p	CLIP-seq
MIRT1485253	hsa-miR-4701-5p	CLIP-seq
MIRT1485279	hsa-miR-4704-5p	CLIP-seq
MIRT1485280	hsa-miR-4789-5p	CLIP-seq
MIRT1485254	hsa-miR-519a	CLIP-seq
MIRT1485255	hsa-miR-519b-3p	CLIP-seq
MIRT1485256	hsa-miR-519c-3p	CLIP-seq
MIRT1485257	hsa-miR-519d	CLIP-seq
MIRT1485281	hsa-miR-552	CLIP-seq
MIRT1485282	hsa-miR-567	CLIP-seq
MIRT1485258	hsa-miR-588	CLIP-seq
MIRT1485259	hsa-miR-676	CLIP-seq
MIRT1485260	hsa-miR-802	CLIP-seq
MIRT1485261	hsa-miR-93	CLIP-seq
MIRT1485283	hsa-miR-96	CLIP-seq
MIRT2145957	hsa-miR-1245	CLIP-seq
MIRT1485259	hsa-miR-676	CLIP-seq
MIRT1485221	hsa-miR-106a	CLIP-seq
MIRT1485222	hsa-miR-106b	CLIP-seq
MIRT2366362	hsa-miR-1207-3p	CLIP-seq
MIRT2145957	hsa-miR-1245	CLIP-seq
MIRT1485264	hsa-miR-1271	CLIP-seq
MIRT1485265	hsa-miR-1284	CLIP-seq
MIRT2366363	hsa-miR-136	CLIP-seq
MIRT1485226	hsa-miR-17	CLIP-seq
MIRT1485267	hsa-miR-182	CLIP-seq
MIRT1485227	hsa-miR-20a	CLIP-seq
MIRT1485228	hsa-miR-20b	CLIP-seq
MIRT1485229	hsa-miR-2117	CLIP-seq
MIRT2366364	hsa-miR-219-5p	CLIP-seq
MIRT1485272	hsa-miR-297	CLIP-seq
MIRT1485273	hsa-miR-300	CLIP-seq
MIRT2366365	hsa-miR-302a	CLIP-seq
MIRT2366366	hsa-miR-302b	CLIP-seq
MIRT2366367	hsa-miR-302c	CLIP-seq
MIRT2366368	hsa-miR-302d	CLIP-seq
MIRT2366369	hsa-miR-302e	CLIP-seq
MIRT1485232	hsa-miR-3145-3p	CLIP-seq
MIRT1485236	hsa-miR-3192	CLIP-seq
MIRT1485241	hsa-miR-326	CLIP-seq
MIRT1485242	hsa-miR-330-5p	CLIP-seq
MIRT2366370	hsa-miR-3653	CLIP-seq
MIRT2366371	hsa-miR-3658	CLIP-seq
MIRT2366372	hsa-miR-372	CLIP-seq
MIRT2366373	hsa-miR-373	CLIP-seq
MIRT1485276	hsa-miR-381	CLIP-seq
MIRT2366374	hsa-miR-4264	CLIP-seq
MIRT1485244	hsa-miR-4273	CLIP-seq
MIRT2366375	hsa-miR-4311	CLIP-seq
MIRT1485245	hsa-miR-4314	CLIP-seq
MIRT2366376	hsa-miR-4445	CLIP-seq
MIRT2366377	hsa-miR-450b-5p	CLIP-seq
MIRT1485250	hsa-miR-4646-5p	CLIP-seq
MIRT1485278	hsa-miR-4666-3p	CLIP-seq
MIRT1485251	hsa-miR-4677-5p	CLIP-seq
MIRT1485252	hsa-miR-4699-3p	CLIP-seq
MIRT1485279	hsa-miR-4704-5p	CLIP-seq
MIRT2366378	hsa-miR-4720-3p	CLIP-seq
MIRT2366379	hsa-miR-4782-3p	CLIP-seq
MIRT1485280	hsa-miR-4789-5p	CLIP-seq
MIRT2366380	hsa-miR-4804-3p	CLIP-seq
MIRT2366381	hsa-miR-508-3p	CLIP-seq
MIRT2366382	hsa-miR-513a-3p	CLIP-seq
MIRT2366383	hsa-miR-518a-5p	CLIP-seq
MIRT1485257	hsa-miR-519d	CLIP-seq
MIRT2366384	hsa-miR-520a-3p	CLIP-seq
MIRT2366385	hsa-miR-520b	CLIP-seq
MIRT2366386	hsa-miR-520c-3p	CLIP-seq
MIRT2366387	hsa-miR-520d-3p	CLIP-seq
MIRT2366388	hsa-miR-520e	CLIP-seq
MIRT2366389	hsa-miR-520f	CLIP-seq
MIRT2366390	hsa-miR-520g	CLIP-seq
MIRT2366391	hsa-miR-527	CLIP-seq
MIRT1485281	hsa-miR-552	CLIP-seq
MIRT1485282	hsa-miR-567	CLIP-seq
MIRT2366392	hsa-miR-622	CLIP-seq
MIRT2366393	hsa-miR-640	CLIP-seq
MIRT1485261	hsa-miR-93	CLIP-seq
MIRT1485283	hsa-miR-96	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
CEBPA	Unknown	10064725
HIC1	Repression	24076391
PPARG	Activation	19861583

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	TAS	10380922
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	8083232, 10571240, 10571241, 17330141, 17548821, 20223215, 32296183, 33961781
GO:0005615	Component	Extracellular space	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10380922
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IDA	10571240
GO:0007165	Process	Signal transduction	TAS	10380922
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10380922
GO:0007613	Process	Memory	TAS	7550352
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0016020	Component	Membrane	IDA	15082773
GO:0016020	Component	Membrane	IEA
GO:0021517	Process	Ventral spinal cord development	IEA
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IDA	8083232
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IEA
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	TAS	20005821
GO:0034185	Function	Apolipoprotein binding	IBA
GO:0034185	Function	Apolipoprotein binding	IDA	10571240
GO:0034185	Function	Apolipoprotein binding	ISS
GO:0034189	Function	Very-low-density lipoprotein particle binding	IDA	10571240
GO:0034361	Component	Very-low-density lipoprotein particle	IEA
GO:0034436	Process	Glycoprotein transport	IDA	10571240
GO:0034447	Process	Very-low-density lipoprotein particle clearance	IDA	8083232
GO:0038024	Function	Cargo receptor activity	IDA	10571240
GO:0038025	Function	Reelin receptor activity	IEA
GO:0038025	Function	Reelin receptor activity	ISS
GO:0038026	Process	Reelin-mediated signaling pathway	IEA
GO:0038026	Process	Reelin-mediated signaling pathway	ISS
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045202	Component	Synapse	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	10571240
GO:0048813	Process	Dendrite morphogenesis	IEA
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900006	Process	Positive regulation of dendrite development	IEA
GO:1900006	Process	Positive regulation of dendrite development	ISS

MIM	HGNC	e!Ensembl
192977	12698	ENSG00000147852

P98155

Protein name

Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R)

Protein function

Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E

PDB

1V9U , 3DPR , 6BYV , 8IHP , 8UA4 , 8UA8 , 8UFB , 8UFC , 8X0K , 8X0L , 8X0M , 8XI4 , 8XI5 , 8YS2 , 8YS4 , 8YVZ , 8YW0 , 8YW1 , 8YW2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00057	Ldl_recept_a	31 → 67	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	70 → 108	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	111 → 149	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	152 → 188	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	191 → 229	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	237 → 273	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	276 → 312	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	316 → 355	Low-density lipoprotein receptor domain class A	Repeat
PF14670	FXa_inhibition	360 → 394		Domain
PF07645	EGF_CA	396 → 434	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	481 → 522	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	525 → 565	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	568 → 609	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	612 → 654	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	655 → 695	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	706 → 749		Domain

Tissue specificity

TISSUE SPECIFICITY: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Sequence

MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA

Sequence length

873

Interactions

View interactions

	KEGG		Reactome
	Spinocerebellar ataxia Lipid and atherosclerosis		Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance

276

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormality of the nervous system	Pathogenic	rs2130810638	RCV001814487
Cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1	Pathogenic; Likely pathogenic	rs1428899305, rs2130810631, rs2130785730, rs141396971, rs1404412704, rs761330915, rs797046092, rs770269674, rs1563758564, rs2488718618, rs778298702, rs80338907, rs80338906, rs1817930102, rs2488711363 View all (8 more)	RCV005040332 RCV001784014 RCV001807943 RCV002227004 RCV002283985 RCV002284300 RCV002051689 RCV002051690 RCV003325245 RCV003152927 RCV003155822 RCV000020557 RCV000020556 RCV003325251 RCV003325252 RCV003325253 RCV003325254 RCV005047808 RCV003988145 RCV000020555 RCV000785940 RCV000049269 RCV000054559
Cerebellar hypoplasia	Pathogenic	rs397514750	RCV004798764
Dysequilibrium syndrome	Likely pathogenic	rs2130801524	RCV002272962
VLDLR-related disorder	Pathogenic	rs955974361	RCV003893478

Show/Hide Unknown Diseases (19)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs140938258	RCV005925963
Cervical cancer	Likely benign	rs12348518	RCV005916429
Cholangiocarcinoma	Benign; Likely benign	rs11789583	RCV005889388
Congenital cerebellar hypoplasia	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs11789583, rs6143, rs148487944, rs6149, rs79720897, rs6148, rs6145, rs34336270, rs2242105, rs2219143, rs35782329, rs35339834, rs145995735, rs141850403, rs182216426 View all (41 more)	RCV000313450 RCV000370518 RCV000298244 RCV000333724 RCV000380151 RCV000285729 RCV000376598 RCV000311900 RCV000261481 RCV000276346 RCV000348298 RCV000270534 RCV000379212 RCV000287225 RCV000397896 RCV000359068 RCV000338938 RCV000308352 RCV000271545 RCV000328821 RCV000389212 RCV000373923 RCV000365308 RCV000340977 RCV000344566 RCV000291026 RCV000263076 RCV000320640 RCV000325553 RCV000337113 RCV000278361 RCV000308615 RCV000363802 RCV000385757 RCV000368967 RCV000283835 RCV000404689 RCV000355556 RCV000312186 RCV000366823 RCV000404429 RCV000278431 RCV000335588 RCV000402819 RCV000304150 RCV000273136 RCV000372010 RCV000319042 RCV000407386 RCV000406430 RCV000363490 RCV000274811 RCV000332222 RCV000281608 RCV000375905 RCV000404867 RCV000321941 RCV000282109 RCV000352066
Familial cancer of breast	Benign; Likely benign	rs11789583	RCV005889385
Gastric cancer	not provided	rs758394485	RCV005937373
Intellectual disability	Conflicting classifications of pathogenicity	rs139671268	RCV001252624
Lung cancer	Conflicting classifications of pathogenicity	rs116306908	RCV005900679
Malignant tumor of esophagus	Likely benign	rs113992002	RCV005916189
Malignant tumor of urinary bladder	Conflicting classifications of pathogenicity	rs141850403	RCV005892397
Melanoma	Conflicting classifications of pathogenicity	rs141850403	RCV005892400
Microcephaly	Uncertain significance	rs770125563	RCV001252704
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs11789583	RCV005889386
Ovarian serous cystadenocarcinoma	Conflicting classifications of pathogenicity	rs141850403	RCV005892399
See cases	Uncertain significance	rs116047052, rs2130796679	RCV002252700 RCV002253040
Thymoma	Likely benign	rs34843491	RCV005915071
Uterine carcinosarcoma	Benign; Likely benign	rs11789583, rs2290465	RCV005889387 RCV005902332
Uterine corpus endometrial carcinoma	Likely benign	rs113992002	RCV005916190
Uveal melanoma	Conflicting classifications of pathogenicity; Benign	rs141850403, rs2290465	RCV005892398 RCV005902331

Show/Hide Text Mining Associations (45)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	15884130, 21047397
Ataxia	Associate	19332571
Atherosclerosis	Associate	29042132, 8669483
Autistic Disorder	Associate	36039581
Breast Neoplasms	Associate	17696882
Carcinoma Renal Cell	Stimulate	23185271
Carotid Artery Diseases	Associate	18056683
Central Nervous System Infections	Associate	37876925
Cerebellar Ataxia	Associate	22532556
Cerebellar Hypoplasia	Associate	16080122, 18326629, 19332571, 22532556
Congenital Abnormalities	Associate	22532556
Cystic Fibrosis	Associate	35738281
Dementia	Associate	34913545
Dental Plaque	Stimulate	29042132
Diastrophic dysplasia	Associate	27108886
Dysequilibrium syndrome	Associate	18326629, 19332571, 21885617, 22973972, 29371607
Gait Ataxia	Associate	18326629, 22532556
Gallbladder Neoplasms	Associate	24903309
Gambling	Associate	22780124
Gastroenteritis	Associate	15884130
Genetic Diseases Inborn	Associate	19332571
Heart Diseases	Associate	24662412
Hyperglycemia	Inhibit	11010963
Hyperlipoproteinemia Type II	Associate	28199412
Hypertriglyceridemic Waist	Associate	8669483
Infections	Associate	37876925
Insulin Resistance	Associate	10726903
Intellectual Disability	Associate	19332571, 22532556
Lp(A) Deficiency Congenital	Associate	16080122
Macular Degeneration	Associate	22355348
Malformations of Cortical Development	Associate	22532556, 32570172
Metabolic Syndrome	Associate	31405227
Mobility Limitation	Associate	19332571
Neoplasms	Associate	21606492
Non alcoholic Fatty Liver Disease	Associate	34988225
Obesity	Associate	20975297
Pain	Stimulate	29156912
Pancreatitis	Associate	35738281
Pancreatitis Chronic	Associate	35738281
Polycystic Ovary Syndrome	Associate	39773546
Pontocerebellar Hypoplasia	Associate	22532556
Reperfusion Injury	Stimulate	24662412
Seizures	Associate	19332571
Stomach Neoplasms	Associate	15884130, 36196723
Thymoma	Associate	34219124

VLDLR (very low density lipoprotein receptor)