Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7433
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Vasoactive intestinal peptide receptor 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
VIPR1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R |
Chromosome
Chromosome number
|
3 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3p22.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its act |
UniProt ID |
P32241
|
Protein name |
Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) |
Protein function |
G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 a |
PDB |
1OF2
,
1OGT
,
3B3I
,
3B6S
,
3DTX
,
3HCV
,
5DEF
,
5DEG
,
5IB1
,
5IB2
,
5IB3
,
5IB4
,
5IB5
,
6VN7
,
7ALO
,
8E3Y
,
8E3Z
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02793
|
HRM |
60 → 125 |
Hormone receptor domain |
Family |
PF00002
|
7tm_2 |
139 → 384 |
7 transmembrane receptor (Secretin family) |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in |
Sequence |
|
Sequence length |
457 |
Interactions |
View interactions
|