Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7433
Gene name Gene Name - the full gene name approved by the HGNC.
Vasoactive intestinal peptide receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VIPR1
Synonyms (NCBI Gene) Gene synonyms aliases
HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its act
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT609742 hsa-miR-4499 HITS-CLIP 23824327
MIRT609741 hsa-miR-4494 HITS-CLIP 23824327
MIRT609740 hsa-miR-1224-3p HITS-CLIP 23824327
MIRT609739 hsa-miR-532-3p HITS-CLIP 23824327
MIRT609738 hsa-miR-4513 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IBA 21873635
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IDA 8390245
GO:0005515 Function Protein binding IPI 23597562, 32296183
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
192321 12694 ENSG00000114812
Protein
UniProt ID P32241
Protein name Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R)
Protein function G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 a
PDB 1OF2 , 1OGT , 3B3I , 3B6S , 3DTX , 3HCV , 5DEF , 5DEG , 5IB1 , 5IB2 , 5IB3 , 5IB4 , 5IB5 , 6VN7 , 7ALO , 8E3Y , 8E3Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 60 125 Hormone receptor domain Family
PF00002 7tm_2 139 384 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in
Sequence
Sequence length 457
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35561270, 36032660, 38095636
Alzheimer Disease Associate 25390694
Arthritis Associate 26881970
Arthritis Rheumatoid Associate 10555038, 26881970
Arthritis Rheumatoid Stimulate 25430993
Autoimmune Diseases Associate 31089161
Breast Neoplasms Associate 17727979
Bronchitis Chronic Associate 15572539
Carcinoma Hepatocellular Associate 34424809
Carcinoma Hepatocellular Inhibit 35864952, 36038907