Gene Gene information from NCBI Gene database.
Entrez ID 7433
Gene name Vasoactive intestinal peptide receptor 1
Gene symbol VIPR1
Synonyms (NCBI Gene)
HVR1IIPACAP-R-2PACAP-R2RDC1V1RGVAPC1VIP-R-1VIPRVIRGVPAC1VPAC1RVPCAP1R
Chromosome 3
Chromosome location 3p22.1
Summary This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its act
miRNA miRNA information provided by mirtarbase database.
329
miRTarBase ID miRNA Experiments Reference
MIRT609742 hsa-miR-4499 HITS-CLIP 23824327
MIRT609741 hsa-miR-4494 HITS-CLIP 23824327
MIRT609740 hsa-miR-1224-3p HITS-CLIP 23824327
MIRT609739 hsa-miR-532-3p HITS-CLIP 23824327
MIRT609738 hsa-miR-4513 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0001634 Function Pituitary adenylate cyclase-activating polypeptide receptor activity IDA 36385145
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IBA
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IDA 8390245, 36385145
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
192321 12694 ENSG00000114812
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P32241
Protein name Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R)
Protein function G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 a
PDB 1OF2 , 1OGT , 3B3I , 3B6S , 3DTX , 3HCV , 5DEF , 5DEG , 5IB1 , 5IB2 , 5IB3 , 5IB4 , 5IB5 , 6VN7 , 7ALO , 8E3Y , 8E3Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 60 125 Hormone receptor domain Family
PF00002 7tm_2 139 384 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in
Sequence
Sequence length 457
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Benign rs3733055 RCV005908644
Hepatocellular carcinoma Benign rs3733055 RCV005908642
Malignant tumor of esophagus Benign rs3733055 RCV005908643
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35561270, 36032660, 38095636
Alzheimer Disease Associate 25390694
Arthritis Associate 26881970
Arthritis Rheumatoid Associate 10555038, 26881970
Arthritis Rheumatoid Stimulate 25430993
Autoimmune Diseases Associate 31089161
Breast Neoplasms Associate 17727979
Bronchitis Chronic Associate 15572539
Carcinoma Hepatocellular Associate 34424809
Carcinoma Hepatocellular Inhibit 35864952, 36038907